SNURF_MOUSE
ID SNURF_MOUSE Reviewed; 71 AA.
AC Q9WU12; Q924D8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=SNRPN upstream reading frame protein;
GN Name=Snurf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=10318933; DOI=10.1073/pnas.96.10.5616;
RA Gray T.A., Saitoh S., Nicholls R.D.;
RT "An imprinted, mammalian bicistronic transcript encodes two independent
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=11431693; DOI=10.1038/90067;
RA Bressler J., Tsai T.F., Wu M.Y., Tsai S.F., Ramirez M.A., Armstrong D.,
RA Beaudet A.L.;
RT "The SNRPN promoter is not required for genomic imprinting of the Prader-
RT Willi/Angelman domain in mice.";
RL Nat. Genet. 28:232-240(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=16429232; DOI=10.1007/s10038-005-0351-8;
RA Mapendano C.K., Kishino T., Miyazaki K., Kondo S., Yoshiura K.,
RA Hishikawa Y., Koji T., Niikawa N., Ohta T.;
RT "Expression of the Snurf-Snrpn IC transcript in the oocyte and its putative
RT role in the imprinting establishment of the mouse 7C imprinting domain.";
RL J. Hum. Genet. 51:236-243(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10318933}.
CC -!- TISSUE SPECIFICITY: Expressed in brain and embryonic stem (ES) cells
CC (at protein level). Expressed in the brain, ovary, testis, liver,
CC heart, kidney and muscle. {ECO:0000269|PubMed:10318933,
CC ECO:0000269|PubMed:16429232}.
CC -!- MISCELLANEOUS: Encoded on a bicistronic transcript that code for two
CC proteins, SNRPN and SNURF. Only the primary 1.6-kb bicistronic SNURF-
CC SNRPN transcript is detected.
CC -!- SIMILARITY: Belongs to the SNURF family. {ECO:0000305}.
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DR EMBL; AF101042; AAD31389.1; -; mRNA.
DR EMBL; AF332579; AAK77666.1; -; Genomic_DNA.
DR EMBL; AF332579; AAK77667.1; -; Genomic_DNA.
DR EMBL; BC132082; AAI32083.1; -; mRNA.
DR EMBL; BC132084; AAI32085.1; -; mRNA.
DR CCDS; CCDS57553.1; -.
DR RefSeq; NP_149409.1; NM_033174.3.
DR AlphaFoldDB; Q9WU12; -.
DR iPTMnet; Q9WU12; -.
DR PhosphoSitePlus; Q9WU12; -.
DR PaxDb; Q9WU12; -.
DR PRIDE; Q9WU12; -.
DR ProteomicsDB; 261464; -.
DR DNASU; 84704; -.
DR Ensembl; ENSMUST00000179360; ENSMUSP00000136053; ENSMUSG00000000948.
DR Ensembl; ENSMUST00000194059; ENSMUSP00000141531; ENSMUSG00000102627.
DR GeneID; 84704; -.
DR KEGG; mmu:84704; -.
DR CTD; 8926; -.
DR MGI; MGI:1891236; Snurf.
DR VEuPathDB; HostDB:ENSMUSG00000000948; -.
DR VEuPathDB; HostDB:ENSMUSG00000102627; -.
DR GeneTree; ENSGT00390000009320; -.
DR HOGENOM; CLU_165583_0_0_1; -.
DR InParanoid; Q9WU12; -.
DR OMA; QVKHRIA; -.
DR TreeFam; TF338383; -.
DR BioGRID-ORCS; 84704; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Snurf; mouse.
DR PRO; PR:Q9WU12; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9WU12; protein.
DR Bgee; ENSMUSG00000000948; Expressed in epiblast (generic) and 57 other tissues.
DR ExpressionAtlas; Q9WU12; baseline and differential.
DR Genevisible; Q9WU12; MM.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005685; C:U1 snRNP; ISO:MGI.
DR GO; GO:0005686; C:U2 snRNP; ISO:MGI.
DR GO; GO:0051117; F:ATPase binding; IPI:MGI.
DR InterPro; IPR009847; SNURF.
DR PANTHER; PTHR14508; PTHR14508; 1.
DR Pfam; PF07192; SNURF; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..71
FT /note="SNRPN upstream reading frame protein"
FT /id="PRO_0000312994"
FT CONFLICT 2..4
FT /note="ERG -> QQP (in Ref. 2; AAK77667)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 71 AA; 8407 MW; 89BEEFAA81D3076C CRC64;
MERGRDRLHL RRTTEQHVPE VEVQVKRRRT ASLSNQECHL YPRRSQQQQV PVVDFQAELR
QAFLAETPRG G
