ID   SNX11_BOVIN             Reviewed;         270 AA.
AC   Q08DD7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Sorting nexin-11;
GN   Name=SNX11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphoinositide-binding protein involved in protein sorting
CC       and membrane trafficking in endosomes. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endosome
CC       {ECO:0000250}.
CC   -!- DOMAIN: The PX domain mediates interaction with membranes enriched in
CC       phosphatidylinositol 3-phosphate. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR   EMBL; BC123805; AAI23806.1; -; mRNA.
DR   RefSeq; NP_001070372.1; NM_001076904.1.
DR   AlphaFoldDB; Q08DD7; -.
DR   SMR; Q08DD7; -.
DR   STRING; 9913.ENSBTAP00000027082; -.
DR   PaxDb; Q08DD7; -.
DR   PRIDE; Q08DD7; -.
DR   Ensembl; ENSBTAT00000027082; ENSBTAP00000027082; ENSBTAG00000020321.
DR   GeneID; 534567; -.
DR   KEGG; bta:534567; -.
DR   CTD; 29916; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020321; -.
DR   VGNC; VGNC:35092; SNX11.
DR   eggNOG; KOG2527; Eukaryota.
DR   GeneTree; ENSGT00940000160113; -.
DR   HOGENOM; CLU_057172_3_0_1; -.
DR   InParanoid; Q08DD7; -.
DR   OMA; DQPNSCC; -.
DR   OrthoDB; 1407986at2759; -.
DR   TreeFam; TF332117; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000020321; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901981; F:phosphatidylinositol phosphate binding; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016050; P:vesicle organization; ISS:UniProtKB.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR043544; SNX10/11.
DR   PANTHER; PTHR46209; PTHR46209; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lipid-binding; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..270
FT                   /note="Sorting nexin-11"
FT                   /id="PRO_0000271385"
FT   DOMAIN          16..132
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   REGION          135..139
FT                   /note="Important for membrane trafficking"
FT                   /evidence="ECO:0000250"
FT   REGION          168..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          251..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         59
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
FT   BINDING         85
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
FT   BINDING         99
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   270 AA;  30205 MW;  449DDACBE28D2C3E CRC64;
     MGFWCRMLEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT AKTSCVRRRY
     REFVWLRKQL QRNAGLVPVP ELPGKSTFFG SSDEFIEKRR QGLQHFLEKV LQSVVLLSDS
     QLHLFLQSQL SVPEIEACVQ GRSPVSVSDA ILRYAMSNCG WAQEERRGSS HLAEGDQPKS
     CCFLPRPGRR SSPSPPPGEE KDPFEVWAPV VDSEAPPLES PTLPPTSSPS CCGFARPDEG
     LSASQPVRRV LGGGHAVPLD PGQLETVLEK