SNX12_SCHPO
ID SNX12_SCHPO Reviewed; 1010 AA.
AC Q9USN1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Sorting nexin-12;
GN Name=snx12; ORFNames=SPCC16A11.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR EMBL; CU329672; CAB53076.1; -; Genomic_DNA.
DR PIR; T41077; T41077.
DR RefSeq; NP_587991.1; NM_001022982.2.
DR AlphaFoldDB; Q9USN1; -.
DR SMR; Q9USN1; -.
DR BioGRID; 275331; 5.
DR STRING; 4896.SPCC16A11.04.1; -.
DR iPTMnet; Q9USN1; -.
DR MaxQB; Q9USN1; -.
DR PaxDb; Q9USN1; -.
DR PRIDE; Q9USN1; -.
DR EnsemblFungi; SPCC16A11.04.1; SPCC16A11.04.1:pep; SPCC16A11.04.
DR GeneID; 2538748; -.
DR KEGG; spo:SPCC16A11.04; -.
DR PomBase; SPCC16A11.04; snx12.
DR VEuPathDB; FungiDB:SPCC16A11.04; -.
DR eggNOG; KOG2101; Eukaryota.
DR HOGENOM; CLU_002131_1_0_1; -.
DR InParanoid; Q9USN1; -.
DR OMA; LYALMGE; -.
DR PhylomeDB; Q9USN1; -.
DR PRO; PR:Q9USN1; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0098853; C:endoplasmic reticulum-vacuole membrane contact site; IC:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0071561; C:nucleus-vacuole junction; ISO:PomBase.
DR GO; GO:0005773; C:vacuole; ISO:PomBase.
DR GO; GO:0035091; F:phosphatidylinositol binding; ISM:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:1990854; P:vacuole-ER tethering; ISO:PomBase.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1010
FT /note="Sorting nexin-12"
FT /id="PRO_0000316573"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 88..274
FT /note="PXA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147,
FT ECO:0000255|PROSITE-ProRule:PRU00553"
FT DOMAIN 390..529
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT DOMAIN 698..815
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT REGION 923..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 622..692
FT /evidence="ECO:0000255"
SQ SEQUENCE 1010 AA; 116993 MW; 2A8D19194177F1DB CRC64;
MYQQHIFYFI TGGIFILWIL AHSFFVKIIY LWASGCLLWY CLETRTFENK NNLGTSEPFL
VNPAIFQKRA RQLALSKLLL RQPLYPGIPE ISEEIESIIS HFMQKYIKVW SYQIIPEPTI
SNSIESHLRK CLMVLLSRVD EIDLADVLVK TVLPLITKHL RLFVEAEQLV VGNKAVSFTD
HSELSREVAA KYDHGRLHEA VLLSGNPMVA QKRYLRNWTT QVLSIILPNY YETSPLVLSL
VTEVIINTTL LPLVSYISDP DFFNYLIIQA SGSIIQRRRK IRRLKRAIRK QSNHFQVGAR
RLRLKDSQHS FEQYIHEIKK ISNISDARRL RSELMVQRRQ LEQTEAFDFE FKQYRERLQI
AIITAEKRIS LLSGTPFQHK EAVLFEQVQS LLQILSDSAA VSCFLEFMER KNRSRYLHFW
LVVEGLKESQ DDPLNAHMIA PFSDIVSDHT DFTAIVKSYF ESVDNPLDIP KPLTNTINKF
VNQSKDNLNP DLWVEARNAM LMAQEHVFDI MQNSDYSEFV NSEIYYRFLA QDVVSDHKST
NSSATFSRLE ELGENIPAIS KQPSYLSISS SSKSINSSPS PSIQLSVSSS ISRDKNLSPL
DLELDDPTYS DEEEVLFAPP GDLQLSESID ELNNNIEELK AQLNAINTLI KKAELVADQK
QLKSLTKNHQ EIEKAIHRKE RQRDQYMSQE EDSKLFNRSR VSIDSFKISK EENTPDFAVY
TIRIERLENG HVRSGWMVAR RYREFAELHK QLKQTYPGVR SLKFPQKSII TSLNKNVLEY
RRGALEEYLQ SLFRMPEVCD SKMLRMFLSQ QNITAPQMFN PKEVGKKWKQ LLEVLGFEVN
NSFNASNVNT NSSFSGPISE FLVELFSPND DAKQQWLPKK TYISILEQLF GGALEKRIRL
QLFQLFTPEK IYRKLREFRR GLEGKSNHDH SKDRRHSRAR KPAYADRNQL KAEAGILLAS
MFPGYTPDIA VKRIFRILQN QSLNAHVIYT LLDEILLALK KHARSTNKAT
