SNX13_HUMAN
ID SNX13_HUMAN Reviewed; 968 AA.
AC Q9Y5W8; B2RCI9; O94821; Q8WVZ2; Q8WXH8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2002, sequence version 4.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Sorting nexin-13;
DE AltName: Full=RGS domain- and PHOX domain-containing protein;
DE AltName: Full=RGS-PX1;
GN Name=SNX13; Synonyms=KIAA0713;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH G
RP PROTEIN-COUPLED RECEPTORS, DOMAIN PX, AND SUBCELLULAR LOCATION.
RX PubMed=11729322; DOI=10.1126/science.1064757;
RA Zheng B., Ma Y.C., Ostrom R.S., Lavoie C., Gill G.N., Insel P.A.,
RA Huang X.Y., Farquhar M.G.;
RT "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking.";
RL Science 294:1939-1942(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XI. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:277-286(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 607-968.
RX PubMed=11485546; DOI=10.1042/0264-6021:3580007;
RA Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.;
RT "A large family of endosome-localized proteins related to sorting nexin
RT 1.";
RL Biochem. J. 358:7-16(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 651-968.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8;
RA Hillman R.T., Green R.E., Brenner S.E.;
RT "An unappreciated role for RNA surveillance.";
RL Genome Biol. 5:R8.1-R8.16(2004).
CC -!- FUNCTION: May be involved in several stages of intracellular
CC trafficking. May play a role in endosome homeostasis (By similarity).
CC Acts as a GAP for Galphas. {ECO:0000250, ECO:0000269|PubMed:11729322}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000269|PubMed:11729322}; Peripheral membrane protein
CC {ECO:0000269|PubMed:11729322}; Cytoplasmic side
CC {ECO:0000269|PubMed:11729322}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5W8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y5W8-2; Sequence=VSP_006192;
CC -!- DOMAIN: The PX domain mediates interaction with membranes enriched in
CC phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11729322}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22060.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA34433.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF420470; AAL37728.1; -; mRNA.
DR EMBL; AB018256; BAA34433.1; ALT_FRAME; mRNA.
DR EMBL; AK315135; BAG37586.1; -; mRNA.
DR EMBL; AF121862; AAD27835.1; -; mRNA.
DR EMBL; CH471073; EAW93690.1; -; Genomic_DNA.
DR EMBL; BC022060; AAH22060.1; ALT_INIT; mRNA.
DR CCDS; CCDS47551.1; -. [Q9Y5W8-2]
DR RefSeq; NP_055947.1; NM_015132.4. [Q9Y5W8-2]
DR RefSeq; XP_005249729.1; XM_005249672.1.
DR AlphaFoldDB; Q9Y5W8; -.
DR SMR; Q9Y5W8; -.
DR BioGRID; 116773; 17.
DR IntAct; Q9Y5W8; 8.
DR STRING; 9606.ENSP00000398789; -.
DR GlyGen; Q9Y5W8; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9Y5W8; -.
DR PhosphoSitePlus; Q9Y5W8; -.
DR BioMuta; SNX13; -.
DR DMDM; 24418867; -.
DR EPD; Q9Y5W8; -.
DR jPOST; Q9Y5W8; -.
DR MassIVE; Q9Y5W8; -.
DR MaxQB; Q9Y5W8; -.
DR PaxDb; Q9Y5W8; -.
DR PeptideAtlas; Q9Y5W8; -.
DR PRIDE; Q9Y5W8; -.
DR ProteomicsDB; 86522; -. [Q9Y5W8-1]
DR ProteomicsDB; 86523; -. [Q9Y5W8-2]
DR Antibodypedia; 25298; 91 antibodies from 23 providers.
DR DNASU; 23161; -.
DR Ensembl; ENST00000428135.7; ENSP00000398789.2; ENSG00000071189.21. [Q9Y5W8-2]
DR GeneID; 23161; -.
DR KEGG; hsa:23161; -.
DR MANE-Select; ENST00000428135.7; ENSP00000398789.2; NM_015132.5; NP_055947.1. [Q9Y5W8-2]
DR UCSC; uc003stv.4; human. [Q9Y5W8-1]
DR CTD; 23161; -.
DR DisGeNET; 23161; -.
DR GeneCards; SNX13; -.
DR HGNC; HGNC:21335; SNX13.
DR HPA; ENSG00000071189; Low tissue specificity.
DR MIM; 606589; gene.
DR neXtProt; NX_Q9Y5W8; -.
DR OpenTargets; ENSG00000071189; -.
DR PharmGKB; PA129697240; -.
DR VEuPathDB; HostDB:ENSG00000071189; -.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_005899_1_0_1; -.
DR InParanoid; Q9Y5W8; -.
DR OMA; EWTPTNV; -.
DR OrthoDB; 187001at2759; -.
DR PhylomeDB; Q9Y5W8; -.
DR TreeFam; TF324055; -.
DR PathwayCommons; Q9Y5W8; -.
DR SignaLink; Q9Y5W8; -.
DR BioGRID-ORCS; 23161; 36 hits in 1079 CRISPR screens.
DR ChiTaRS; SNX13; human.
DR GeneWiki; SNX13; -.
DR GenomeRNAi; 23161; -.
DR Pharos; Q9Y5W8; Tbio.
DR PRO; PR:Q9Y5W8; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9Y5W8; protein.
DR Bgee; ENSG00000071189; Expressed in sperm and 199 other tissues.
DR ExpressionAtlas; Q9Y5W8; baseline and differential.
DR Genevisible; Q9Y5W8; HS.
DR GO; GO:0005769; C:early endosome; IDA:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IMP:UniProtKB.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IDA:UniProtKB.
DR CDD; cd06873; PX_SNX13; 1.
DR CDD; cd08719; RGS_SNX13; 1.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037437; SNX13_PX.
DR InterPro; IPR037896; SNX13_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endosome; Lipid-binding; Membrane; Protein transport;
KW Reference proteome; Signal transduction inhibitor; Transport.
FT CHAIN 1..968
FT /note="Sorting nexin-13"
FT /id="PRO_0000213860"
FT DOMAIN 97..284
FT /note="PXA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147,
FT ECO:0000255|PROSITE-ProRule:PRU00553"
FT DOMAIN 373..496
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT DOMAIN 570..691
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT BINDING 612
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 614
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 639
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 653
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT VAR_SEQ 569..579
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11729322,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_006192"
FT VARIANT 472
FT /note="L -> S (in dbSNP:rs35113148)"
FT /id="VAR_057333"
FT CONFLICT 638
FT /note="G -> E (in Ref. 1; BAA34433)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 968 AA; 112189 MW; 532994AE0B347FB5 CRC64;
MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF GKTNSEKYLE
QCEHSFLPPT SPGVPKCLEE MKREARTIKI DRRLTGANII DEPLQQVIQF SLRDYVQYWY
YTLSDDESFL LEIRQTLQNA LIQFATRSKE IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT
EKDDQVKGTA EDLVDTFFEV EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD
FQNKIMRYFV REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR LQSGKEINTV
KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL FFWMTVEGYR VTAQQQLEVL
LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL SEKASPRVTV DDYLVAKLAD TLNHEDPTPE
IFDDIQRKVY ELMLRDERFY PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT
GSINLSLDDL SNVSSDDSVQ LHAYISDTVY ADYDPYAVAG VCNDHGKTYA LYAITVHRRN
LNSEEMWKTY RRYSDFHDFH MRITEQFESL SSILKLPGKK TFNNMDRDFL EKRKKDLNAY
LQLLLAPEMM KASPALAHYV YDFLENKAYS KGKGDFARKM DTFVNPLRNS MRNVSNAVKS
LPDSLAEGMT KMSDNMGKMS ERLGQDIKQS FFKVPPLIPK TDSDPEHRRV SAQLDDNVDD
NIPLRVMLLL MDEVFDLKER NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDWMTSPEQ
VADSVKRFRD AFWPNGILAE AVPCRDKSIR MRTRVAGKTK LLAIMPDELK HIIGAETTRK
GILRVFEMFQ HNQLNRRMVY VFLEGFLETL FPQYKFRELF NKLHSRSKQM QKYKQKLQTT
QAPSLQKR
