ID   SNX14_PONAB             Reviewed;         894 AA.
AC   Q5R903;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Sorting nexin-14;
GN   Name=SNX14;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in maintaining normal neuronal excitability and
CC       synaptic transmission. May be involved in several stages of
CC       intracellular trafficking. {ECO:0000250, ECO:0000250|UniProtKB:Q8BHY8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BHY8}. Cell
CC       projection, dendrite {ECO:0000250|UniProtKB:Q8BHY8}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR   EMBL; CR859594; CAH91757.1; -; mRNA.
DR   RefSeq; NP_001126020.1; NM_001132548.1.
DR   AlphaFoldDB; Q5R903; -.
DR   SMR; Q5R903; -.
DR   STRING; 9601.ENSPPYP00000018828; -.
DR   GeneID; 100172967; -.
DR   KEGG; pon:100172967; -.
DR   CTD; 57231; -.
DR   eggNOG; KOG2101; Eukaryota.
DR   InParanoid; Q5R903; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..894
FT                   /note="Sorting nexin-14"
FT                   /id="PRO_0000380111"
FT   DOMAIN          78..252
FT                   /note="PXA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147,
FT                   ECO:0000255|PROSITE-ProRule:PRU00553"
FT   DOMAIN          284..416
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT   DOMAIN          518..638
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   MOD_RES         496
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5W7"
SQ   SEQUENCE   894 AA;  104039 MW;  1F8EF2635C92E11F CRC64;
     MIFWSFVAGV VTFYCSLGPD SLLPNIFFTI KYKPKQLGLQ ELFPQGHSCA VCGKVKCKRH
     RPSLLLENYQ PWLDLKISSK VDASLSEVLE LVLENFVYPW YRDVTDDESF VDELRITLRF
     FASVLIRRIH KVDIPSIITK KLLKAAMKHI EVIVKARQKV KNTEFLQQAA LEEYGPELHV
     ALRSRRDELH YLRKLTELLF PYILPPKATD CRSLTLLIRE ILSGSVFLPS LDFLADPDTV
     NHLLIIFIDD SPPEKATEPA SPLVPFLQKF AEPRNKKPSV LKLELKQIRE QQDLLFRFMN
     FLKQEGAVHV LQFCLTVEEF NDRILRPELS NDEMLSLHEE LQKIYKTYCL DESIDKIRFD
     PFIVEEIQRI AEGPYIDVVK LQTMRCLFEA YEHVLSLLEN VFTPMFCHSD EYFRQLLRGA
     ESPTRNSKLN RGSLSLDDFR NTQKRGESFG ISRIGSKIKG VFKSTTMEGA MLPNYGVAEG
     EDDFIEEGIV VMEDDSPVEA VSTPNTPRNL AAWKISIPYV DFFEDPSSER KEKKERIPVF
     CIDVERNDRR AVGHEPEHWS VYRRYLEFYV LESKLTEFHG TFPDAQLPSK RIIGPKNYEF
     LKSKREEFQE YLQKLLQHPE LSNSQLLADF LSPNGGETQF LDKILPDVNL GKIIKSVPGK
     LMKEKGQHLE PFIMNFINSC ESPKPKPSRP ELTILSPTSE NNKKLFNDLF KNNANRAENT
     ERKQNQNYFM EVMTVEGVYD YLMYVGRVVF QVPDWLHHLL MGTRILFKNT LEMYTDYYLQ
     CKLEQLFQEH RLVSLITLLR DAIFCENTEP RSLQDKQKGA KQTFEEMMNY IPDLLVKCIG
     EETKYESIRL LFDGLQQPVL NKQLTYVLLD IVIQELFPEL NKVQKEVTSV TSWM