ID   SNX15_BOVIN             Reviewed;         345 AA.
AC   Q148E7;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Sorting nexin-15;
GN   Name=SNX15;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in several stages of intracellular
CC       trafficking. Overexpression of SNX15 disrupts the normal trafficking of
CC       proteins from the plasma membrane to recycling endosomes or the TGN (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR   EMBL; BC118397; AAI18398.1; -; mRNA.
DR   RefSeq; NP_001068798.1; NM_001075330.2.
DR   AlphaFoldDB; Q148E7; -.
DR   SMR; Q148E7; -.
DR   STRING; 9913.ENSBTAP00000002897; -.
DR   PaxDb; Q148E7; -.
DR   Ensembl; ENSBTAT00000002897; ENSBTAP00000002897; ENSBTAG00000002243.
DR   GeneID; 507751; -.
DR   KEGG; bta:507751; -.
DR   CTD; 29907; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002243; -.
DR   VGNC; VGNC:35095; SNX15.
DR   eggNOG; KOG0603; Eukaryota.
DR   eggNOG; KOG2101; Eukaryota.
DR   GeneTree; ENSGT00940000160125; -.
DR   HOGENOM; CLU_055745_0_0_1; -.
DR   InParanoid; Q148E7; -.
DR   OMA; YRFFTVT; -.
DR   OrthoDB; 255297at2759; -.
DR   TreeFam; TF323964; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000002243; Expressed in choroid plexus and 104 other tissues.
DR   ExpressionAtlas; Q148E7; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR007330; MIT_dom.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   Pfam; PF04212; MIT; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00745; MIT; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF116846; SSF116846; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   2: Evidence at transcript level;
KW   Methylation; Phosphoprotein; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..345
FT                   /note="Sorting nexin-15"
FT                   /id="PRO_0000290187"
FT   DOMAIN          1..130
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   DOMAIN          272..345
FT                   /note="MIT"
FT   REGION          133..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..157
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         105
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91WE1"
FT   MOD_RES         208
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRS6"
FT   MOD_RES         234
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NRS6"
SQ   SEQUENCE   345 AA;  38403 MW;  56C0009501B6BE25 CRC64;
     MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKRDP EDVKEVVVWK RYSDFRKLHG
     DLAYTHRNLF RRLEEFPAFP RGQVFGRFEA SVIEERRKGA EDLLRFTVHI PALNNSPQLK
     EFFRGGEVTR PSEVSGDLHI LPPPLIPTPP PDEPRVQPHE TWLPQPLPAE RRGLEELEVP
     ADPPPSSPAQ EALDLLFNCG STEEASSSPA RGPLTEAELA LFDPFSKEEG AGPSPTHIGE
     LAALEAGSGR PDQEPWEPGG QAEEDDEEGE PAPAYLSQAT ELITQALRDE KAGAYPAALQ
     GYRDGVHILL QGVPGDPSPA RREGVKKKAA EYLKRAEEIL HLHLS