SNX24_HUMAN
ID SNX24_HUMAN Reviewed; 169 AA.
AC Q9Y343; Q6UY33;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Sorting nexin-24;
GN Name=SNX24; ORFNames=SBBI31, UNQ654/PRO1284;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Zhang W., Wan T., Cao X.;
RT "Hypothetical human protein SBBI31.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Hong W.;
RT "SBBI31 as a new member (SNX24) of the sorting nexin family.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: May be involved in several stages of intracellular
CC trafficking. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9Y343; P14859-6: POU2F1; NbExp=3; IntAct=EBI-727113, EBI-11526590;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y343-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y343-2; Sequence=VSP_012034;
CC -!- DOMAIN: The PX domain mediates specific binding to membranes enriched
CC in phosphatidylinositol 3-phosphate (PtdIns(P3)). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR EMBL; AF139461; AAD32668.1; -; mRNA.
DR EMBL; AY044655; AAK98769.1; -; mRNA.
DR EMBL; AY358098; AAQ88465.1; -; mRNA.
DR EMBL; BC069012; AAH69012.1; -; mRNA.
DR EMBL; BC010886; AAH10886.1; -; mRNA.
DR CCDS; CCDS4132.1; -. [Q9Y343-1]
DR RefSeq; NP_054754.1; NM_014035.2. [Q9Y343-1]
DR PDB; 4AZ9; X-ray; 1.75 A; A/B=1-107.
DR PDBsum; 4AZ9; -.
DR AlphaFoldDB; Q9Y343; -.
DR SMR; Q9Y343; -.
DR BioGRID; 118791; 34.
DR IntAct; Q9Y343; 24.
DR MINT; Q9Y343; -.
DR STRING; 9606.ENSP00000261369; -.
DR iPTMnet; Q9Y343; -.
DR PhosphoSitePlus; Q9Y343; -.
DR BioMuta; SNX24; -.
DR DMDM; 20140349; -.
DR EPD; Q9Y343; -.
DR jPOST; Q9Y343; -.
DR MassIVE; Q9Y343; -.
DR MaxQB; Q9Y343; -.
DR PaxDb; Q9Y343; -.
DR PeptideAtlas; Q9Y343; -.
DR PRIDE; Q9Y343; -.
DR ProteomicsDB; 85973; -. [Q9Y343-1]
DR ProteomicsDB; 85974; -. [Q9Y343-2]
DR Antibodypedia; 25654; 169 antibodies from 23 providers.
DR DNASU; 28966; -.
DR Ensembl; ENST00000261369.9; ENSP00000261369.4; ENSG00000064652.11. [Q9Y343-1]
DR Ensembl; ENST00000506996.5; ENSP00000422535.1; ENSG00000064652.11. [Q9Y343-2]
DR Ensembl; ENST00000513881.5; ENSP00000424149.1; ENSG00000064652.11. [Q9Y343-2]
DR GeneID; 28966; -.
DR KEGG; hsa:28966; -.
DR MANE-Select; ENST00000261369.9; ENSP00000261369.4; NM_014035.4; NP_054754.1.
DR UCSC; uc003ktf.3; human. [Q9Y343-1]
DR CTD; 28966; -.
DR DisGeNET; 28966; -.
DR GeneCards; SNX24; -.
DR HGNC; HGNC:21533; SNX24.
DR HPA; ENSG00000064652; Low tissue specificity.
DR neXtProt; NX_Q9Y343; -.
DR OpenTargets; ENSG00000064652; -.
DR PharmGKB; PA134980773; -.
DR VEuPathDB; HostDB:ENSG00000064652; -.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00390000001280; -.
DR HOGENOM; CLU_117250_1_0_1; -.
DR InParanoid; Q9Y343; -.
DR OMA; TVFRIDV; -.
DR OrthoDB; 1305786at2759; -.
DR PhylomeDB; Q9Y343; -.
DR TreeFam; TF332414; -.
DR PathwayCommons; Q9Y343; -.
DR SignaLink; Q9Y343; -.
DR BioGRID-ORCS; 28966; 8 hits in 1086 CRISPR screens.
DR ChiTaRS; SNX24; human.
DR GenomeRNAi; 28966; -.
DR Pharos; Q9Y343; Tdark.
DR PRO; PR:Q9Y343; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9Y343; protein.
DR Bgee; ENSG00000064652; Expressed in oocyte and 188 other tissues.
DR ExpressionAtlas; Q9Y343; baseline and differential.
DR Genevisible; Q9Y343; HS.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IBA:GO_Central.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0070273; F:phosphatidylinositol-4-phosphate binding; IEA:Ensembl.
DR GO; GO:0010314; F:phosphatidylinositol-5-phosphate binding; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Cytoplasmic vesicle;
KW Lipid-binding; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..169
FT /note="Sorting nexin-24"
FT /id="PRO_0000213872"
FT DOMAIN 1..125
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT BINDING 38
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 40
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 61
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 74
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 113
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CRB0"
FT MOD_RES 116
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CRB0"
FT VAR_SEQ 148..169
FT /note="DFPNVVIEGVLHGIFYPHLQPR -> GNQTCHLLTALY (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_012034"
FT STRAND 2..11
FT /evidence="ECO:0007829|PDB:4AZ9"
FT STRAND 19..28
FT /evidence="ECO:0007829|PDB:4AZ9"
FT STRAND 31..38
FT /evidence="ECO:0007829|PDB:4AZ9"
FT HELIX 39..49
FT /evidence="ECO:0007829|PDB:4AZ9"
FT TURN 50..52
FT /evidence="ECO:0007829|PDB:4AZ9"
FT HELIX 68..88
FT /evidence="ECO:0007829|PDB:4AZ9"
FT HELIX 94..99
FT /evidence="ECO:0007829|PDB:4AZ9"
SQ SEQUENCE 169 AA; 19818 MW; 651B3964493AFE5D CRC64;
MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK KCIKTPEIPS
KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL NVRHLPSLPK AESCGSFDET
ESEESSKLSH QPVLLFLRDP YVLPAASDFP NVVIEGVLHG IFYPHLQPR
