ID   SNX24_RAT               Reviewed;         169 AA.
AC   Q5U2S5;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Sorting nexin-24;
GN   Name=Snx24;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in several stages of intracellular
CC       trafficking. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- DOMAIN: The PX domain mediates specific binding to membranes enriched
CC       in phosphatidylinositol 3-phosphate (PtdIns(P3)). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR   EMBL; BC085883; AAH85883.1; -; mRNA.
DR   RefSeq; NP_001008365.1; NM_001008364.1.
DR   AlphaFoldDB; Q5U2S5; -.
DR   SMR; Q5U2S5; -.
DR   STRING; 10116.ENSRNOP00000023507; -.
DR   iPTMnet; Q5U2S5; -.
DR   PhosphoSitePlus; Q5U2S5; -.
DR   PaxDb; Q5U2S5; -.
DR   PRIDE; Q5U2S5; -.
DR   Ensembl; ENSRNOT00000023507; ENSRNOP00000023507; ENSRNOG00000017488.
DR   GeneID; 361328; -.
DR   KEGG; rno:361328; -.
DR   UCSC; RGD:1306864; rat.
DR   CTD; 28966; -.
DR   RGD; 1306864; Snx24.
DR   eggNOG; KOG2101; Eukaryota.
DR   GeneTree; ENSGT00390000001280; -.
DR   HOGENOM; CLU_117250_1_0_1; -.
DR   InParanoid; Q5U2S5; -.
DR   OMA; TVFRIDV; -.
DR   OrthoDB; 1305786at2759; -.
DR   PhylomeDB; Q5U2S5; -.
DR   TreeFam; TF332414; -.
DR   PRO; PR:Q5U2S5; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Bgee; ENSRNOG00000017488; Expressed in liver and 18 other tissues.
DR   Genevisible; Q5U2S5; RN.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901981; F:phosphatidylinositol phosphate binding; IBA:GO_Central.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISO:RGD.
DR   GO; GO:0070273; F:phosphatidylinositol-4-phosphate binding; ISO:RGD.
DR   GO; GO:0010314; F:phosphatidylinositol-5-phosphate binding; ISO:RGD.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasmic vesicle; Lipid-binding; Membrane; Phosphoprotein;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..169
FT                   /note="Sorting nexin-24"
FT                   /id="PRO_0000213874"
FT   DOMAIN          1..125
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   BINDING         38
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
FT   BINDING         40
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
FT   BINDING         61
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
FT   BINDING         74
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y343"
FT   MOD_RES         113
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CRB0"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CRB0"
SQ   SEQUENCE   169 AA;  19653 MW;  076416D452392D69 CRC64;
     MEVYIPSFRH EDSDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK KCIKTPEIPS
     KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL NVRHLPSLPK AESCGSFDET
     ESEESSKLSH QPVLLFLGDP YVLPAASDFP NVVIEGVLHG IFFSHLQPR