SNX25_MOUSE
ID SNX25_MOUSE Reviewed; 840 AA.
AC Q3ZT31; E9QMG5; Q6PGF1;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Sorting nexin-25;
GN Name=Snx25;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Hao X., Chang Z., Zhu S.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-74.
RC TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-840.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in several stages of intracellular
CC trafficking. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT98626.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AY601646; AAT98626.1; ALT_SEQ; mRNA.
DR EMBL; AC114558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CJ047380; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC057063; AAH57063.1; -; mRNA.
DR CCDS; CCDS22287.2; -.
DR RefSeq; NP_997096.2; NM_207213.2.
DR RefSeq; XP_006509306.1; XM_006509243.3.
DR AlphaFoldDB; Q3ZT31; -.
DR SMR; Q3ZT31; -.
DR BioGRID; 221805; 1.
DR STRING; 10090.ENSMUSP00000106007; -.
DR iPTMnet; Q3ZT31; -.
DR PhosphoSitePlus; Q3ZT31; -.
DR EPD; Q3ZT31; -.
DR MaxQB; Q3ZT31; -.
DR PaxDb; Q3ZT31; -.
DR PRIDE; Q3ZT31; -.
DR ProteomicsDB; 261542; -.
DR Antibodypedia; 28920; 152 antibodies from 27 providers.
DR Ensembl; ENSMUST00000041582; ENSMUSP00000035785; ENSMUSG00000038291.
DR Ensembl; ENSMUST00000170416; ENSMUSP00000127640; ENSMUSG00000038291.
DR GeneID; 102141; -.
DR KEGG; mmu:102141; -.
DR UCSC; uc009lpu.2; mouse.
DR CTD; 83891; -.
DR MGI; MGI:2142610; Snx25.
DR VEuPathDB; HostDB:ENSMUSG00000038291; -.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_005899_0_1_1; -.
DR InParanoid; Q3ZT31; -.
DR BioGRID-ORCS; 102141; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Snx25; mouse.
DR PRO; PR:Q3ZT31; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3ZT31; protein.
DR Bgee; ENSMUSG00000038291; Expressed in spermatocyte and 216 other tissues.
DR ExpressionAtlas; Q3ZT31; baseline and differential.
DR Genevisible; Q3ZT31; MM.
DR GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0034713; F:type I transforming growth factor beta receptor binding; IPI:UniProtKB.
DR GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; ISO:MGI.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032801; P:receptor catabolic process; IDA:UniProtKB.
DR CDD; cd06878; PX_SNX25; 1.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR034905; SNX25.
DR InterPro; IPR037899; SNX25_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775:SF29; PTHR22775:SF29; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Endosome; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..840
FT /note="Sorting nexin-25"
FT /id="PRO_0000352799"
FT DOMAIN 1..164
FT /note="PXA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147,
FT ECO:0000255|PROSITE-ProRule:PRU00553"
FT DOMAIN 287..401
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT DOMAIN 508..628
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT REGION 404..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 446..494
FT /evidence="ECO:0000255"
FT MOD_RES 665
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H3E2"
FT CONFLICT 25
FT /note="S -> T (in Ref. 3; CJ047380)"
FT /evidence="ECO:0000305"
FT CONFLICT 27
FT /note="D -> H (in Ref. 3; CJ047380)"
FT /evidence="ECO:0000305"
FT CONFLICT 45
FT /note="Q -> H (in Ref. 3; CJ047380)"
FT /evidence="ECO:0000305"
FT CONFLICT 48
FT /note="Q -> H (in Ref. 3; CJ047380)"
FT /evidence="ECO:0000305"
FT CONFLICT 57
FT /note="K -> Q (in Ref. 3; CJ047380)"
FT /evidence="ECO:0000305"
FT CONFLICT 61
FT /note="N -> Y (in Ref. 3; CJ047380)"
FT /evidence="ECO:0000305"
FT CONFLICT 70..71
FT /note="HF -> TS (in Ref. 3; CJ047380)"
FT /evidence="ECO:0000305"
FT CONFLICT 73
FT /note="D -> E (in Ref. 3; CJ047380)"
FT /evidence="ECO:0000305"
FT CONFLICT 322
FT /note="H -> D (in Ref. 1; AAT98626)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="E -> D (in Ref. 1; AAT98626)"
FT /evidence="ECO:0000305"
FT CONFLICT 427
FT /note="G -> S (in Ref. 1; AAT98626)"
FT /evidence="ECO:0000305"
FT CONFLICT 646
FT /note="L -> P (in Ref. 1; AAT98626)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 840 AA; 97146 MW; 35B02C44AE7C1B50 CRC64;
MDRVLRDVFD YSYRDYILSW YGNLSRDDGQ LYHLLLDDFW EIVKQIRQRL SHVDVVKVVC
NDIVKALLTH FCDLKAATAR HEEQPRPFVL HACLKDSHDE VRFLQTCSQV LVLCLLPSKD
IQSLSLRTML AEILTTKVLK PVVELLSNPD YINQMLLRQL EYREQMSEHH KRAYTYAPSY
EDFIKLINSN SDVDFLKQLR YQIVVEIIQA TTISSFPQLK RHKGKESAAM KTDLLRARNM
KRYINQLTVA KKQCEKRIRI LGGPAYDQQE DGASDEGEGP QSQKILQFED IMTNPFYRER
FGTYMERIDK RALVGFWESA EHLKNANKSE IPQLVSEMYQ NFFVESKEIS VEKSLYKEIQ
QCLVGNRGIE VFSKIQADVS EVLRERYYPS FLVSDLYEKL MREEEEEEPD AQLASEKDEL
GSGGEAGEEA VEGTSGVSDP ASFAVIKLRE LNEKLEYKRQ ALSSIQNAPK PDKKIISKLK
DEILLIEKEC TALQLHMART DWWCENLGLW RASITSAEVT EENGEQMPCY FVRVNLQEVG
GVETKNWTVP RRLSEFQNLH RKLSECVPSL KKVQLPSLSK LPFKSIDHKF LGKSRNQLNA
FLQNLLSDER LFQSEALYAF LSPSPDYLKV IDVQGKKTSF SLSSFLEKLP RDFFSHQEEE
IEEDSDLSDY GDDVDGKKDS LAEPCFMLIG EIFELRGMFK WVRRTLIALV QVTFGRTINK
QIRDTVSWIS SEQMLVYYIS AFRDAFWPNG KLAPPTRIRS VAQSQETKQR AQQKLLENIP
DTLQSLVGQQ NARHGIIKIF KALQETKANK HLLYVLMELL LTELCPELRA HLDQFKAGQV
