SNX29_MOUSE
ID SNX29_MOUSE Reviewed; 818 AA.
AC Q9D3S3; Q8K050;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Sorting nexin-29;
GN Name=Snx29;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RA Hong W.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 445-682 (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-447; SER-452;
RP THR-644; SER-645 AND SER-649, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-291; SER-292;
RP SER-330; SER-344; SER-452; SER-642; SER-645 AND SER-649, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D3S3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D3S3-3; Sequence=VSP_041966;
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34114.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AF399755; AAK94018.1; -; mRNA.
DR EMBL; AK017102; BAB30596.1; -; mRNA.
DR EMBL; AC154233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC154509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC165252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC167720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034114; AAH34114.1; ALT_SEQ; mRNA.
DR CCDS; CCDS27963.2; -. [Q9D3S3-1]
DR CCDS; CCDS79422.1; -. [Q9D3S3-3]
DR RefSeq; NP_001277077.1; NM_001290148.1. [Q9D3S3-3]
DR RefSeq; NP_083240.2; NM_028964.4. [Q9D3S3-1]
DR AlphaFoldDB; Q9D3S3; -.
DR SMR; Q9D3S3; -.
DR IntAct; Q9D3S3; 1.
DR MINT; Q9D3S3; -.
DR STRING; 10090.ENSMUSP00000093993; -.
DR iPTMnet; Q9D3S3; -.
DR PhosphoSitePlus; Q9D3S3; -.
DR EPD; Q9D3S3; -.
DR jPOST; Q9D3S3; -.
DR MaxQB; Q9D3S3; -.
DR PaxDb; Q9D3S3; -.
DR PRIDE; Q9D3S3; -.
DR ProteomicsDB; 261095; -. [Q9D3S3-1]
DR ProteomicsDB; 261096; -. [Q9D3S3-3]
DR Antibodypedia; 2225; 128 antibodies from 19 providers.
DR DNASU; 74478; -.
DR Ensembl; ENSMUST00000096273; ENSMUSP00000093993; ENSMUSG00000071669. [Q9D3S3-3]
DR Ensembl; ENSMUST00000180792; ENSMUSP00000138025; ENSMUSG00000071669. [Q9D3S3-1]
DR GeneID; 74478; -.
DR KEGG; mmu:74478; -.
DR UCSC; uc007yfj.2; mouse. [Q9D3S3-3]
DR UCSC; uc029swd.1; mouse. [Q9D3S3-1]
DR CTD; 92017; -.
DR MGI; MGI:1921728; Snx29.
DR VEuPathDB; HostDB:ENSMUSG00000071669; -.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00730000110975; -.
DR HOGENOM; CLU_020563_1_0_1; -.
DR InParanoid; Q9D3S3; -.
DR OMA; PFYEEWA; -.
DR OrthoDB; 543799at2759; -.
DR PhylomeDB; Q9D3S3; -.
DR TreeFam; TF352146; -.
DR BioGRID-ORCS; 74478; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Snx29; mouse.
DR PRO; PR:Q9D3S3; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9D3S3; protein.
DR Bgee; ENSMUSG00000071669; Expressed in rostral migratory stream and 186 other tissues.
DR ExpressionAtlas; Q9D3S3; baseline and differential.
DR Genevisible; Q9D3S3; MM.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd07277; PX_RUN; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037916; SNX29_PX.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; SSF140741; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50826; RUN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..818
FT /note="Sorting nexin-29"
FT /id="PRO_0000297566"
FT DOMAIN 36..180
FT /note="RUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT DOMAIN 659..782
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT REGION 267..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 467..547
FT /evidence="ECO:0000255"
FT COMPBIAS 355..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 268
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 291
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 292
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 330
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 344
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 447
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 452
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 642
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 644
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 645
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 649
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..374
FT /note="MSGSQNDDRRQFLLERLLDAVKQCQIRFGGRKEIASDSDSRVTCLCAQFEAV
FT LQHGMKRSRGLALTAAAIKQAAGFTSKTETEPVFWVYVKEVLNKHELQRFYSLHHITSD
FT AGRGRAWLRCALNEHSLERYLHMLLADRARLSTFYEDWSFVMDEERSSMLPTMAAGLNS
FT ILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLKESTQGMSSLLREITASSAVSI
FT LIKPEQETDPLPVISKNVHVDTRCKRERRRRKKVTNIVSFDDDEEEQGTGDTLKKMPGT
FT AESSEENSDRSSVNIMAAFEGTFGPNSNGSQSSSSWKIDSASLNGELGYQKLDVKSIDD
FT DVDENEEDAYRSPLGRGHTGHAESPDR -> MDSLCPVYSGIMIEESAEKPGQELSSDE
FT WLTE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_041966"
SQ SEQUENCE 818 AA; 91387 MW; 909BA070A3D15EE0 CRC64;
MSGSQNDDRR QFLLERLLDA VKQCQIRFGG RKEIASDSDS RVTCLCAQFE AVLQHGMKRS
RGLALTAAAI KQAAGFTSKT ETEPVFWVYV KEVLNKHELQ RFYSLHHITS DAGRGRAWLR
CALNEHSLER YLHMLLADRA RLSTFYEDWS FVMDEERSSM LPTMAAGLNS ILFAINIDNK
DLNGQSKFAP TVSDLLKEST QNVTSLLKES TQGMSSLLRE ITASSAVSIL IKPEQETDPL
PVISKNVHVD TRCKRERRRR KKVTNIVSFD DDEEEQGTGD TLKKMPGTAE SSEENSDRSS
VNIMAAFEGT FGPNSNGSQS SSSWKIDSAS LNGELGYQKL DVKSIDDDVD ENEEDAYRSP
LGRGHTGHAE SPDRTLDGNA CLAQVHGWAP LQVLHGDADA DTDVLFPVSG VGSYGAADAP
VGSLENGTGT ENHIIPEPGL RYREASSPGQ GSPLSSLLPS ASVPESMTVH ELRQAIVAMM
NRKDELEEEN GSLRNLLDGE MEHSAALRQE VDALRRKVTE QQERHATKVQ ALARENEVLK
VQLKKYVGAV QMLKREGQTA EAVPSLWNVD AEVTVPEQKP GEVAEELASS YERKLIEVAE
MHGELIEFNE RLHRALVAKE ALVSQMRQEL IDLRGPVPGD LSQTSEDQSL SDFEISNRAL
INVWIPSVFL RGKAANAFHV YQVYIRIKDD EWNVYRRYTE FRALHHQLQS AFPQVRAYSF
PPKKAIGNKD AKFVEERRKQ LQSYLRSVMN KVIQMVPEFA ANPKKETLVQ LVPFFVDITP
PGEPLNKSSR PKAVSRFPKL SRGHPREVRN VEPQSGDL
