SNX30_XENTR
ID SNX30_XENTR Reviewed; 446 AA.
AC Q28E02;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Sorting nexin-30;
GN Name=snx30; ORFNames=TEgg065l16.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the regulation of endocytosis and in several
CC stages of intracellular trafficking. Together with snx4, involved in
CC autophagosome assembly. {ECO:0000250|UniProtKB:Q5VWJ9}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000250|UniProtKB:Q5VWJ9}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O95219}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:O95219}.
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR EMBL; CR848512; CAJ81312.1; -; mRNA.
DR RefSeq; NP_001016905.1; NM_001016905.2.
DR AlphaFoldDB; Q28E02; -.
DR SMR; Q28E02; -.
DR STRING; 8364.ENSXETP00000004753; -.
DR PaxDb; Q28E02; -.
DR PRIDE; Q28E02; -.
DR GeneID; 549659; -.
DR KEGG; xtr:549659; -.
DR CTD; 401548; -.
DR Xenbase; XB-GENE-944717; snx30.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_040655_1_0_1; -.
DR InParanoid; Q28E02; -.
DR OMA; FIWLRQK; -.
DR OrthoDB; 947320at2759; -.
DR PhylomeDB; Q28E02; -.
DR TreeFam; TF328543; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000002230; Expressed in egg cell and 14 other tissues.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR GO; GO:0061709; P:reticulophagy; IBA:GO_Central.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028649; SNX30.
DR PANTHER; PTHR45949:SF1; PTHR45949:SF1; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 2: Evidence at transcript level;
KW Endosome; Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1..446
FT /note="Sorting nexin-30"
FT /id="PRO_0000284537"
FT DOMAIN 98..219
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT DOMAIN 243..446
FT /note="BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 141
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250|UniProtKB:Q3UR97"
FT BINDING 143
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250|UniProtKB:Q3UR97"
FT BINDING 171
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250|UniProtKB:Q96L94"
FT BINDING 185
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250|UniProtKB:Q6P4T1"
SQ SEQUENCE 446 AA; 50959 MW; 5139CBB3EB5EE420 CRC64;
MSGSSTPKSL PTSGQQSLHD IKHPLSCSPS AEDDAAGENG AVIIESPSPD LPNTEPSSLA
DKDLSLPNGT PADTSSPASS SSLLNRLQLD DDLDGETRDL FVTVDDPKKH VCTMETYITY
RVSTKTTRTE FDLPEYSIRR RYQDFDWLRN KLEETQPTHF IPPLPEKFVV KGVVDRFSEE
FVETRRKALD KFLKRIADHP VLSFNEHFNV FLTAKDLNSH KKQGITLLSK MGESVRYVTS
GYKLRNRPVE FATITDYLDT FQLKLGTIDR IAQRIIKEEV EYLMELREYG PVYSTWSGLE
RELNEPLEGV SACVGNCSTA LEELTEDMSE DFLPVIREYM LYSESMKTVL KKRDQVQAEY
EAKAEAAALK REERSTVPTD VEKCQDKVEC FNADLKADMD RWQNNKRQDF RQLLMGMADK
NIQYYEKCLT AWESIIPLLQ DKQEPK