SNX31_MOUSE
ID SNX31_MOUSE Reviewed; 439 AA.
AC Q6P8Y7; Q8BH14; Q9D690;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Sorting nexin-31;
GN Name=Snx31;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, Skin, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in protein trafficking.
CC {ECO:0000250|UniProtKB:Q8N9S9}.
CC -!- SUBUNIT: Interacts with CCDC22, CCDC93, VPS26C and VPS35L, associates
CC with the retriever and CCC complexes. {ECO:0000250|UniProtKB:Q8N9S9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P8Y7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P8Y7-2; Sequence=VSP_033263;
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR EMBL; AK014536; BAB29419.2; -; mRNA.
DR EMBL; AK034196; BAC28627.1; -; mRNA.
DR EMBL; AK035226; BAC28987.1; -; mRNA.
DR EMBL; BC061007; AAH61007.1; -; mRNA.
DR CCDS; CCDS27430.1; -. [Q6P8Y7-2]
DR CCDS; CCDS84166.1; -. [Q6P8Y7-1]
DR RefSeq; NP_001333951.1; NM_001347022.1. [Q6P8Y7-1]
DR RefSeq; NP_079988.3; NM_025712.4. [Q6P8Y7-2]
DR AlphaFoldDB; Q6P8Y7; -.
DR SMR; Q6P8Y7; -.
DR DIP; DIP-60339N; -.
DR IntAct; Q6P8Y7; 3.
DR STRING; 10090.ENSMUSP00000013755; -.
DR PhosphoSitePlus; Q6P8Y7; -.
DR MaxQB; Q6P8Y7; -.
DR PaxDb; Q6P8Y7; -.
DR PRIDE; Q6P8Y7; -.
DR ProteomicsDB; 261598; -. [Q6P8Y7-1]
DR ProteomicsDB; 261599; -. [Q6P8Y7-2]
DR Antibodypedia; 13167; 63 antibodies from 14 providers.
DR DNASU; 66696; -.
DR Ensembl; ENSMUST00000013755; ENSMUSP00000013755; ENSMUSG00000013611. [Q6P8Y7-2]
DR Ensembl; ENSMUST00000161202; ENSMUSP00000124063; ENSMUSG00000013611. [Q6P8Y7-1]
DR GeneID; 66696; -.
DR KEGG; mmu:66696; -.
DR UCSC; uc007vmv.1; mouse. [Q6P8Y7-2]
DR UCSC; uc007vmw.1; mouse. [Q6P8Y7-1]
DR CTD; 169166; -.
DR MGI; MGI:1913946; Snx31.
DR VEuPathDB; HostDB:ENSMUSG00000013611; -.
DR eggNOG; KOG3784; Eukaryota.
DR GeneTree; ENSGT00950000183212; -.
DR HOGENOM; CLU_041342_0_0_1; -.
DR InParanoid; Q6P8Y7; -.
DR OMA; LHDWNEQ; -.
DR OrthoDB; 577861at2759; -.
DR PhylomeDB; Q6P8Y7; -.
DR TreeFam; TF318398; -.
DR BioGRID-ORCS; 66696; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Snx31; mouse.
DR PRO; PR:Q6P8Y7; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6P8Y7; protein.
DR Bgee; ENSMUSG00000013611; Expressed in urinary bladder urothelium and 48 other tissues.
DR Genevisible; Q6P8Y7; MM.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IDA:MGI.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037831; SNX17/27/31.
DR InterPro; IPR040842; SNX17/31_FERM.
DR PANTHER; PTHR12431; PTHR12431; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF18116; SNX17_FERM_C; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Protein transport; Reference proteome; Transport.
FT CHAIN 1..439
FT /note="Sorting nexin-31"
FT /id="PRO_0000331604"
FT DOMAIN 1..109
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT REGION 384..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 410
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033263"
FT CONFLICT 288
FT /note="A -> S (in Ref. 1; BAB29419)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 439 AA; 50862 MW; 7EBA127EF76BE397 CRC64;
MKMHFCIPVS QQRPDALGGR YVLYSVYLDG FLFCKVRYSQ LHRWDEQLRR VFGNCLPPFP
PKYYLAMTTA MAEERRDQLE RYLQNVTADP RVTRSDVFTE FLTLVQLHTL NITIQNVELA
VFLPDGRSIK VEGLTSDTAE RVLEVMAHKL GLQPDLVGYF GLFLIQCFPE GKLSVVKKLA
DFELPYTSLQ SSEMENCKIG LRKWYLDPAL DSMLMDCRAA GDLLYMQAVQ DIEKEWMKPT
QAQREELKAL QKKENQTKFL ELSQEVRHYG YVQLDPCTCN HPEPGCGAQL SIGNNEISCC
ITLPNGQIQD IAFQMSRVKC WQVTFLGTLL DTDGPQRTLN QNLELRFQYS EDSCQQWFVI
YTKQAFFLSS CLKKMISERM TKLTEQSPEM QIEVPEQGRS KKHPSQPSQQ KVYFNFLRKG
KMKRSEGDYV WDTLMEEGL
