SNX32_HUMAN
ID SNX32_HUMAN Reviewed; 403 AA.
AC Q86XE0; Q8IW53; Q96NG4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Sorting nexin-32;
DE AltName: Full=Sorting nexin-6B;
GN Name=SNX32; Synonyms=SNX6B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Brain cortex;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ASN-155;
RP VAL-282 AND TYR-354.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in several stages of intracellular
CC trafficking. {ECO:0000250}.
CC -!- INTERACTION:
CC Q86XE0; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-8099743, EBI-7317823;
CC Q86XE0; A0A0C4DGQ7: EML2; NbExp=3; IntAct=EBI-8099743, EBI-12112376;
CC Q86XE0; A8MXD5: GRXCR1; NbExp=3; IntAct=EBI-8099743, EBI-5235612;
CC Q86XE0; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-8099743, EBI-743811;
CC Q86XE0; Q9Y5B8: NME7; NbExp=5; IntAct=EBI-8099743, EBI-744782;
CC Q86XE0; Q13596: SNX1; NbExp=11; IntAct=EBI-8099743, EBI-2822329;
CC Q86XE0; O60749: SNX2; NbExp=4; IntAct=EBI-8099743, EBI-1046690;
CC Q86XE0; Q9NS25: SPANXB1; NbExp=3; IntAct=EBI-8099743, EBI-17197485;
CC Q86XE0; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-8099743, EBI-1105213;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86XE0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86XE0-2; Sequence=VSP_031742, VSP_031743;
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK055496; BAB70935.1; -; mRNA.
DR EMBL; AK289587; BAF82276.1; -; mRNA.
DR EMBL; CH471076; EAW74441.1; -; Genomic_DNA.
DR EMBL; BC040981; AAH40981.1; -; mRNA.
DR EMBL; BC045563; AAH45563.1; -; mRNA.
DR CCDS; CCDS8113.2; -. [Q86XE0-1]
DR RefSeq; NP_689973.2; NM_152760.2. [Q86XE0-1]
DR PDB; 6E8R; X-ray; 2.27 A; A/B=17-166.
DR PDBsum; 6E8R; -.
DR AlphaFoldDB; Q86XE0; -.
DR SMR; Q86XE0; -.
DR BioGRID; 129016; 28.
DR IntAct; Q86XE0; 19.
DR MINT; Q86XE0; -.
DR STRING; 9606.ENSP00000310620; -.
DR iPTMnet; Q86XE0; -.
DR PhosphoSitePlus; Q86XE0; -.
DR BioMuta; SNX32; -.
DR DMDM; 74727816; -.
DR jPOST; Q86XE0; -.
DR MassIVE; Q86XE0; -.
DR MaxQB; Q86XE0; -.
DR PaxDb; Q86XE0; -.
DR PeptideAtlas; Q86XE0; -.
DR PRIDE; Q86XE0; -.
DR ProteomicsDB; 70267; -. [Q86XE0-1]
DR ProteomicsDB; 70268; -. [Q86XE0-2]
DR Antibodypedia; 29952; 131 antibodies from 21 providers.
DR DNASU; 254122; -.
DR Ensembl; ENST00000308342.7; ENSP00000310620.6; ENSG00000172803.18. [Q86XE0-1]
DR GeneID; 254122; -.
DR KEGG; hsa:254122; -.
DR MANE-Select; ENST00000308342.7; ENSP00000310620.6; NM_152760.3; NP_689973.2.
DR UCSC; uc001ofr.4; human. [Q86XE0-1]
DR CTD; 254122; -.
DR DisGeNET; 254122; -.
DR GeneCards; SNX32; -.
DR HGNC; HGNC:26423; SNX32.
DR HPA; ENSG00000172803; Group enriched (brain, choroid plexus).
DR neXtProt; NX_Q86XE0; -.
DR OpenTargets; ENSG00000172803; -.
DR PharmGKB; PA162404314; -.
DR VEuPathDB; HostDB:ENSG00000172803; -.
DR eggNOG; KOG1660; Eukaryota.
DR GeneTree; ENSGT00940000162773; -.
DR HOGENOM; CLU_040966_0_0_1; -.
DR InParanoid; Q86XE0; -.
DR OMA; ETHQQLC; -.
DR OrthoDB; 1009572at2759; -.
DR PhylomeDB; Q86XE0; -.
DR TreeFam; TF313698; -.
DR PathwayCommons; Q86XE0; -.
DR SignaLink; Q86XE0; -.
DR BioGRID-ORCS; 254122; 33 hits in 1073 CRISPR screens.
DR ChiTaRS; SNX32; human.
DR GenomeRNAi; 254122; -.
DR Pharos; Q86XE0; Tdark.
DR PRO; PR:Q86XE0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q86XE0; protein.
DR Bgee; ENSG00000172803; Expressed in right frontal lobe and 100 other tissues.
DR Genevisible; Q86XE0; HS.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016241; P:regulation of macroautophagy; NAS:ParkinsonsUK-UCL.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014637; SNX5/SNX6/SNX32.
DR InterPro; IPR015404; Vps5_C.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF036924; Snx5_Snx6; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..403
FT /note="Sorting nexin-32"
FT /id="PRO_0000320707"
FT DOMAIN 20..168
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT COILED 258..335
FT /evidence="ECO:0000255"
FT VAR_SEQ 238..277
FT /note="LADDYIPISAALSSLGTQEVNQLRTSFLKLAELFERLRKL -> TQGPRGPG
FT SPCPSPQRFNSLGERREQGVPCCLSVATSTKA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031742"
FT VAR_SEQ 278..403
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031743"
FT VARIANT 155
FT /note="H -> N (in dbSNP:rs17854065)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_039298"
FT VARIANT 282
FT /note="A -> V (in dbSNP:rs17855647)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_039299"
FT VARIANT 354
FT /note="S -> Y (in dbSNP:rs17857243)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_039300"
FT CONFLICT 14
FT /note="S -> P (in Ref. 1; BAB70935)"
FT /evidence="ECO:0000305"
FT STRAND 26..35
FT /evidence="ECO:0007829|PDB:6E8R"
FT STRAND 40..48
FT /evidence="ECO:0007829|PDB:6E8R"
FT STRAND 53..63
FT /evidence="ECO:0007829|PDB:6E8R"
FT HELIX 64..76
FT /evidence="ECO:0007829|PDB:6E8R"
FT HELIX 78..80
FT /evidence="ECO:0007829|PDB:6E8R"
FT HELIX 95..106
FT /evidence="ECO:0007829|PDB:6E8R"
FT HELIX 113..147
FT /evidence="ECO:0007829|PDB:6E8R"
FT HELIX 151..153
FT /evidence="ECO:0007829|PDB:6E8R"
FT HELIX 155..162
FT /evidence="ECO:0007829|PDB:6E8R"
SQ SEQUENCE 403 AA; 46399 MW; 9100676299AE2C19 CRC64;
METYAEVGKE GKPSCASVDL QGDSSLQVEI SDAVSERDKV KFTVQTKSCL PHFAQTEFSV
VRQHEEFIWL HDAYVENEEY AGLIIPPAPP RPDFEASREK LQKLGEGDSS VTREEFAKMK
QELEAEYLAI FKKTVAMHEV FLQRLAAHPT LRRDHNFFVF LEYGQDLSVR GKNRKELLGG
FLRNIVKSAD EALITGMSGL KEVDDFFEHE RTFLLEYHTR IRDACLRADR VMRAHKCLAD
DYIPISAALS SLGTQEVNQL RTSFLKLAEL FERLRKLEGR VASDEDLKLS DMLRYYMRDS
QAAKDLLYRR LRALADYENA NKALDKARTR NREVRPAESH QQLCCQRFER LSDSAKQELM
DFKSRRVSSF RKNLIELAEL ELKHAKASTL ILRNTLVALK GEP
