SNX7_HUMAN
ID SNX7_HUMAN Reviewed; 387 AA.
AC Q9UNH6; A8KAF3; D3DT50; Q53FQ3; Q5VT09; Q5VT10; Q86U82; Q8WVD4; Q96FW9;
AC Q9Y3Z7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Sorting nexin-7 {ECO:0000303|PubMed:32513819, ECO:0000303|Ref.10};
GN Name=SNX7 {ECO:0000303|PubMed:32513819, ECO:0000303|Ref.10,
GN ECO:0000312|HGNC:HGNC:14971};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND PARTIAL NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Gastric mucosa, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RX PubMed=11485546; DOI=10.1042/0264-6021:3580007;
RA Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.;
RT "A large family of endosome-localized proteins related to sorting nexin
RT 1.";
RL Biochem. J. 358:7-16(2001).
RN [7]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-132 (ISOFORM 3).
RA Tsai J.Y., Wistow G.;
RT "Expressed sequence tag analysis of cultured primary human ocular
RT pericytes.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 25-154.
RG Structural genomics consortium (SGC);
RT "Human sorting nexin 7, phox homology (PX) domain.";
RL Submitted (SEP-2009) to the PDB data bank.
RN [11]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH SNX4.
RX PubMed=32513819; DOI=10.1242/jcs.246306;
RA Anton Z., Betin V.M.S., Simonetti B., Traer C.J., Attar N., Cullen P.J.,
RA Lane J.D.;
RT "A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates ATG9A
RT trafficking for efficient autophagosome assembly.";
RL J. Cell Sci. 133:0-0(2020).
CC -!- FUNCTION: Involved in the regulation of endocytosis and in several
CC stages of intracellular trafficking (PubMed:32513819). Together with
CC SNX4, involved in autophagosome assembly by regulating trafficking and
CC recycling of phospholipid scramblase ATG9A (PubMed:32513819).
CC {ECO:0000269|PubMed:32513819}.
CC -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4.
CC {ECO:0000269|PubMed:32513819}.
CC -!- INTERACTION:
CC Q9UNH6; O14964: HGS; NbExp=3; IntAct=EBI-751422, EBI-740220;
CC Q9UNH6; O95219: SNX4; NbExp=2; IntAct=EBI-751422, EBI-724909;
CC Q9UNH6; Q8IYF3: TEX11; NbExp=4; IntAct=EBI-751422, EBI-742397;
CC Q9UNH6-3; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-12424584, EBI-11096309;
CC Q9UNH6-3; O95219: SNX4; NbExp=4; IntAct=EBI-12424584, EBI-724909;
CC Q9UNH6-3; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-12424584, EBI-12018146;
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000269|PubMed:32513819}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O95219}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:O95219}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UNH6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UNH6-2; Sequence=VSP_006191;
CC Name=3;
CC IsoId=Q9UNH6-3; Sequence=VSP_039044;
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD27830.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD96949.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BT006747; AAP35393.1; -; mRNA.
DR EMBL; AK223229; BAD96949.1; ALT_INIT; mRNA.
DR EMBL; AK293018; BAF85707.1; -; mRNA.
DR EMBL; AL627442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471097; EAW72995.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW72996.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW72997.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW72998.1; -; Genomic_DNA.
DR EMBL; BC010349; AAH10349.1; -; mRNA.
DR EMBL; BC018105; AAH18105.1; -; mRNA.
DR EMBL; AF121857; AAD27830.1; ALT_INIT; mRNA.
DR EMBL; AL049989; CAB43229.1; -; mRNA.
DR EMBL; CN483413; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS755.2; -. [Q9UNH6-3]
DR RefSeq; NP_057060.2; NM_015976.4. [Q9UNH6-3]
DR RefSeq; NP_689424.2; NM_152238.3.
DR RefSeq; XP_006710741.1; XM_006710678.2.
DR RefSeq; XP_011539866.1; XM_011541564.2. [Q9UNH6-1]
DR RefSeq; XP_016856914.1; XM_017001425.1. [Q9UNH6-1]
DR RefSeq; XP_016856915.1; XM_017001426.1. [Q9UNH6-1]
DR RefSeq; XP_016856916.1; XM_017001427.1. [Q9UNH6-1]
DR RefSeq; XP_016856917.1; XM_017001428.1. [Q9UNH6-2]
DR PDB; 3IQ2; X-ray; 1.70 A; A/B=25-154.
DR PDBsum; 3IQ2; -.
DR AlphaFoldDB; Q9UNH6; -.
DR SMR; Q9UNH6; -.
DR BioGRID; 119508; 17.
DR IntAct; Q9UNH6; 20.
DR MINT; Q9UNH6; -.
DR STRING; 9606.ENSP00000304429; -.
DR iPTMnet; Q9UNH6; -.
DR PhosphoSitePlus; Q9UNH6; -.
DR BioMuta; SNX7; -.
DR DMDM; 12643904; -.
DR EPD; Q9UNH6; -.
DR jPOST; Q9UNH6; -.
DR MassIVE; Q9UNH6; -.
DR MaxQB; Q9UNH6; -.
DR PaxDb; Q9UNH6; -.
DR PeptideAtlas; Q9UNH6; -.
DR PRIDE; Q9UNH6; -.
DR ProteomicsDB; 85293; -. [Q9UNH6-1]
DR ProteomicsDB; 85294; -. [Q9UNH6-2]
DR ProteomicsDB; 85295; -. [Q9UNH6-3]
DR Antibodypedia; 33676; 178 antibodies from 23 providers.
DR DNASU; 51375; -.
DR Ensembl; ENST00000306121.8; ENSP00000304429.3; ENSG00000162627.17. [Q9UNH6-3]
DR GeneID; 51375; -.
DR KEGG; hsa:51375; -.
DR MANE-Select; ENST00000306121.8; ENSP00000304429.3; NM_015976.5; NP_057060.2. [Q9UNH6-3]
DR UCSC; uc010ouc.3; human. [Q9UNH6-1]
DR CTD; 51375; -.
DR DisGeNET; 51375; -.
DR GeneCards; SNX7; -.
DR HGNC; HGNC:14971; SNX7.
DR HPA; ENSG00000162627; Low tissue specificity.
DR MIM; 614904; gene.
DR neXtProt; NX_Q9UNH6; -.
DR OpenTargets; ENSG00000162627; -.
DR PharmGKB; PA37947; -.
DR VEuPathDB; HostDB:ENSG00000162627; -.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00940000155315; -.
DR HOGENOM; CLU_040655_0_0_1; -.
DR InParanoid; Q9UNH6; -.
DR OMA; EECLATW; -.
DR OrthoDB; 990775at2759; -.
DR PhylomeDB; Q9UNH6; -.
DR TreeFam; TF328543; -.
DR PathwayCommons; Q9UNH6; -.
DR SignaLink; Q9UNH6; -.
DR BioGRID-ORCS; 51375; 9 hits in 1026 CRISPR screens.
DR ChiTaRS; SNX7; human.
DR EvolutionaryTrace; Q9UNH6; -.
DR GenomeRNAi; 51375; -.
DR Pharos; Q9UNH6; Tbio.
DR PRO; PR:Q9UNH6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9UNH6; protein.
DR Bgee; ENSG00000162627; Expressed in tibia and 199 other tissues.
DR ExpressionAtlas; Q9UNH6; baseline and differential.
DR Genevisible; Q9UNH6; HS.
DR GO; GO:0005769; C:early endosome; IDA:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IMP:UniProtKB.
DR GO; GO:0061709; P:reticulophagy; IBA:GO_Central.
DR CDD; cd07666; BAR_SNX7; 1.
DR CDD; cd07284; PX_SNX7; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR042131; BAR_SNX7.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042130; PX_SNX7.
DR InterPro; IPR028656; SNX7.
DR PANTHER; PTHR45949:SF3; PTHR45949:SF3; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Endosome; Lipid-binding; Membrane;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..387
FT /note="Sorting nexin-7"
FT /id="PRO_0000213848"
FT DOMAIN 30..151
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT DOMAIN 178..387
FT /note="BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT BINDING 73
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250|UniProtKB:Q3UR97"
FT BINDING 75
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250|UniProtKB:Q3UR97"
FT BINDING 103
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250|UniProtKB:Q96L94"
FT BINDING 117
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250|UniProtKB:Q6P4T1"
FT VAR_SEQ 1
FT /note="M -> MEGERRASQAPSSGLPAGGANGESPGGGAPFPGSSGSSALLQAEVLD
FT LDEDEDDLEVFSKDASLM (in isoform 3)"
FT /evidence="ECO:0000303|Ref.8"
FT /id="VSP_039044"
FT VAR_SEQ 312..362
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_006191"
FT VARIANT 186
FT /note="F -> L (in dbSNP:rs35391040)"
FT /id="VAR_057331"
FT VARIANT 278
FT /note="S -> N (in dbSNP:rs12033678)"
FT /id="VAR_057332"
FT CONFLICT 59
FT /note="S -> T (in Ref. 2; BAD96949)"
FT /evidence="ECO:0000305"
FT CONFLICT 105
FT /note="M -> I (in Ref. 7; CAB43229)"
FT /evidence="ECO:0000305"
FT CONFLICT 108..109
FT /note="RF -> PG (in Ref. 8; CN483413)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="S -> P (in Ref. 5; AAH10349)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="M -> T (in Ref. 7; CAB43229)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="K -> R (in Ref. 2; BAD96949)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="E -> G (in Ref. 7; CAB43229)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="F -> L (in Ref. 7; CAB43229)"
FT /evidence="ECO:0000305"
FT STRAND 33..43
FT /evidence="ECO:0007829|PDB:3IQ2"
FT STRAND 48..58
FT /evidence="ECO:0007829|PDB:3IQ2"
FT STRAND 60..64
FT /evidence="ECO:0007829|PDB:3IQ2"
FT STRAND 67..73
FT /evidence="ECO:0007829|PDB:3IQ2"
FT HELIX 74..87
FT /evidence="ECO:0007829|PDB:3IQ2"
FT HELIX 107..109
FT /evidence="ECO:0007829|PDB:3IQ2"
FT HELIX 111..130
FT /evidence="ECO:0007829|PDB:3IQ2"
FT HELIX 134..136
FT /evidence="ECO:0007829|PDB:3IQ2"
FT HELIX 138..145
FT /evidence="ECO:0007829|PDB:3IQ2"
SQ SEQUENCE 387 AA; 45303 MW; E703B3EC6013DC1F CRC64;
MDMNSFSPMM PTSPLSMINQ IKFEDEPDLK DLFITVDEPE SHVTTIETFI TYRIITKTSR
GEFDSSEFEV RRRYQDFLWL KGKLEEAHPT LIIPPLPEKF IVKGMVERFN DDFIETRRKA
LHKFLNRIAD HPTLTFNEDF KIFLTAQAWE LSSHKKQGPG LLSRMGQTVR AVASSMRGVK
NRPEEFMEMN NFIELFSQKI NLIDKISQRI YKEEREYFDE MKEYGPIHIL WSASEEDLVD
TLKDVASCID RCCKATEKRM SGLSEALLPV VHEYVLYSEM LMGVMKRRDQ IQAELDSKVE
VLTYKKADTD LLPEEIGKLE DKVECANNAL KADWERWKQN MQNDIKLAFT DMAEENIHYY
EQCLATWESF LTSQTNLHLE EASEDKP
