ID   SNX7_MACFA              Reviewed;         387 AA.
AC   Q4R5U9;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Sorting nexin-7;
GN   Name=SNX7; ORFNames=QtsA-20671;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of endocytosis and in several
CC       stages of intracellular trafficking. Together with SNX4, involved in
CC       autophagosome assembly by regulating trafficking and recycling of
CC       phospholipid scramblase ATG9A. {ECO:0000250|UniProtKB:Q9UNH6}.
CC   -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4.
CC       {ECO:0000250|UniProtKB:Q9UNH6}.
CC   -!- SUBCELLULAR LOCATION: Early endosome membrane
CC       {ECO:0000250|UniProtKB:Q9UNH6}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O95219}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:O95219}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR   EMBL; AB169444; BAE01526.1; -; mRNA.
DR   AlphaFoldDB; Q4R5U9; -.
DR   SMR; Q4R5U9; -.
DR   STRING; 9541.XP_005542683.1; -.
DR   eggNOG; KOG2273; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:2000786; P:positive regulation of autophagosome assembly; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR   CDD; cd07666; BAR_SNX7; 1.
DR   CDD; cd07284; PX_SNX7; 1.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR042131; BAR_SNX7.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR042130; PX_SNX7.
DR   InterPro; IPR028656; SNX7.
DR   PANTHER; PTHR45949:SF3; PTHR45949:SF3; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lipid-binding; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..387
FT                   /note="Sorting nexin-7"
FT                   /id="PRO_0000213849"
FT   DOMAIN          30..151
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   DOMAIN          178..387
FT                   /note="BAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT   BINDING         73
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UR97"
FT   BINDING         75
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UR97"
FT   BINDING         103
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250|UniProtKB:Q96L94"
FT   BINDING         117
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4T1"
SQ   SEQUENCE   387 AA;  45324 MW;  2A727F80112D632F CRC64;
     MDMNSFSPMM PTSPLSMINQ IKFEDEPDLK DLFITVDEPE SHVTTIETFI TYRIITKTSR
     GEFDSSEFEV RRRYQDFLWL KGKLEEAHPT LIIPPLPEKF IVKGMVERFN DDFIETRRKA
     LHKFLNRIAD HPTLTFNEDF KIFLTAQAWE LSSHKKQGPG LLSRMGQTVR AVASSMRGVK
     NRPEEFMEMN NFIELFSQKI NLIDKISQRI YKEEREYFDE MKEYGPIHIL WSASEEDLVD
     TLKDVAGCID RCCKATEKRM SGLSEALLPV VREYVLYSEM LMGVMKRRDQ IQAELDSKVE
     ALTYKKTDTD LLPEEIGKLE DKVECANNAL KADWERWKQN MQNDIKLAFT DMAEENIHYY
     EQCLATWESF LTSQTNLHLE ETSEDKP