ID   SNX8_BOVIN              Reviewed;         459 AA.
AC   Q2KHV6;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Sorting nexin-8;
GN   Name=SNX8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in several stages of intracellular
CC       trafficking. May play a role in intracellular protein transport from
CC       early endosomes to the trans-Golgi network (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Note=Colocalizes with retromer components. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR   EMBL; BC112867; AAI12868.1; -; mRNA.
DR   RefSeq; NP_001039998.1; NM_001046533.2.
DR   AlphaFoldDB; Q2KHV6; -.
DR   SMR; Q2KHV6; -.
DR   STRING; 9913.ENSBTAP00000018213; -.
DR   PaxDb; Q2KHV6; -.
DR   PRIDE; Q2KHV6; -.
DR   Ensembl; ENSBTAT00000018213; ENSBTAP00000018213; ENSBTAG00000013708.
DR   GeneID; 614344; -.
DR   KEGG; bta:614344; -.
DR   CTD; 29886; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013708; -.
DR   VGNC; VGNC:35114; SNX8.
DR   eggNOG; KOG2273; Eukaryota.
DR   GeneTree; ENSGT00460000041594; -.
DR   HOGENOM; CLU_042580_0_0_1; -.
DR   InParanoid; Q2KHV6; -.
DR   OMA; YLENKMV; -.
DR   OrthoDB; 793604at2759; -.
DR   TreeFam; TF314082; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000013708; Expressed in cortex of kidney and 105 other tissues.
DR   ExpressionAtlas; Q2KHV6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR   GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
DR   GO; GO:0034498; P:early endosome to Golgi transport; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
DR   CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR028662; SNX8/Mvp1.
DR   InterPro; IPR035704; SNX8/Mvp1_PX.
DR   InterPro; IPR045734; Snx8_BAR_dom.
DR   PANTHER; PTHR46571; PTHR46571; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF19566; Snx8_BAR_dom; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lipid-binding; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..459
FT                   /note="Sorting nexin-8"
FT                   /id="PRO_0000290188"
FT   DOMAIN          68..176
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         104
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
FT   BINDING         130
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
FT   BINDING         143
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT                   inositol-3-phosphate)"
FT                   /ligand_id="ChEBI:CHEBI:58088"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   459 AA;  51619 MW;  572458DB2C96518E CRC64;
     MTGGAMDPLP TAPGAAAAEA EVDEEADPPA ADSPVPPVSE PRAPDAGQMQ VPPGNPLLLS
     LTLQELLARD AVQVELVPEK KGLFLKHVEY EVSSQRFKSC VYRRYNDFVV FHETLLHKFP
     YRMVPALPPK RMLGADREFI EARRRALKRF INLVARHPPF SEDTILKLFL SFSGPDVQNK
     LKESAQCLGD EFMNCRLAAR AKDFLPADIQ TQFAMSRELI RNIYNSFHKL RDRAERMVSR
     AIDNAADLLI FGKELSALGS DTTPLPSWAS LNSSTWGSLK QALKGLSVEF ALLADKAAQQ
     GKQEENDVVE KLNLFLDLLQ SYKDLCERHE KGVLHKHQRA LHKYSLMKRQ MVSAAVQSRE
     PESMEQLESR IVQQENVIQT MELRSHFSLY CLHQETQLVH VYLPLTSHIL GAFVNSQIQG
     HKEMSKVWND LQPKLRCLFV GPHGAPAPPR PPQDGLSAH