SNXAA_DANRE
ID SNXAA_DANRE Reviewed; 229 AA.
AC F1Q506; Q7SXF9;
DT 24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Sorting nexin-10A;
GN Name=snx10a; ORFNames=im:7153949;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION IN CILIOGENESIS, AND DEVELOPMENTAL STAGE.
RX PubMed=21844891; DOI=10.1038/cr.2011.134;
RA Chen Y., Wu B., Xu L., Li H., Xia J., Yin W., Li Z., Shi D., Li S., Lin S.,
RA Shu X., Pei D.;
RT "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.";
RL Cell Res. 22:333-345(2012).
CC -!- FUNCTION: Probable phosphoinositide-binding protein involved in protein
CC sorting and membrane trafficking in endosomes. May play a role in
CC cilium biogenesis through regulation of the transport and the
CC localization of proteins to the cilium. {ECO:0000269|PubMed:21844891}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F1Q506-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F1Q506-2; Sequence=VSP_047511, VSP_047512, VSP_047513;
CC -!- DEVELOPMENTAL STAGE: Expressed in 10-somite stage embryos but not
CC spatially restricted. {ECO:0000269|PubMed:21844891}.
CC -!- DOMAIN: The PX domain mediates interaction with membranes enriched in
CC phosphatidylinositol 3-phosphate. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH55622.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CABZ01083873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01083874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055622; AAH55622.1; ALT_INIT; mRNA.
DR RefSeq; NP_001132934.1; NM_001139462.1. [F1Q506-1]
DR AlphaFoldDB; F1Q506; -.
DR SMR; F1Q506; -.
DR STRING; 7955.ENSDARP00000098673; -.
DR PaxDb; F1Q506; -.
DR Ensembl; ENSDART00000022803; ENSDARP00000025688; ENSDARG00000004405. [F1Q506-1]
DR Ensembl; ENSDART00000108627; ENSDARP00000098673; ENSDARG00000004405. [F1Q506-1]
DR Ensembl; ENSDART00000187722; ENSDARP00000147490; ENSDARG00000004405. [F1Q506-2]
DR Ensembl; ENSDART00000190659; ENSDARP00000150398; ENSDARG00000004405. [F1Q506-1]
DR GeneID; 403027; -.
DR KEGG; dre:403027; -.
DR CTD; 403027; -.
DR ZFIN; ZDB-GENE-050809-44; snx10a.
DR eggNOG; KOG2527; Eukaryota.
DR GeneTree; ENSGT00940000156007; -.
DR InParanoid; F1Q506; -.
DR OMA; FPVEHEE; -.
DR OrthoDB; 1407986at2759; -.
DR PhylomeDB; F1Q506; -.
DR TreeFam; TF332117; -.
DR PRO; PR:F1Q506; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000004405; Expressed in cleaving embryo and 26 other tissues.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0070121; P:Kupffer's vesicle development; IMP:UniProtKB.
DR GO; GO:0070986; P:left/right axis specification; IMP:UniProtKB.
DR GO; GO:0071539; P:protein localization to centrosome; ISS:UniProtKB.
DR GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR GO; GO:0016050; P:vesicle organization; IBA:GO_Central.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR043544; SNX10/11.
DR PANTHER; PTHR46209; PTHR46209; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Endosome; Lipid-binding; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..229
FT /note="Sorting nexin-10A"
FT /id="PRO_0000423047"
FT DOMAIN 11..128
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT BINDING 54
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT BINDING 95
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-3-phosphate)"
FT /ligand_id="ChEBI:CHEBI:58088"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..41
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_047511"
FT VAR_SEQ 176..188
FT /note="STTSSGLGCSIEP -> RCVPASLYVLWIM (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_047512"
FT VAR_SEQ 189..229
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_047513"
SQ SEQUENCE 229 AA; 26388 MW; 0CAD5D553BFD0C38 CRC64;
MDNTSFEKRE FISVWVRDPQ VHKEDFWHTY ISYEICLHTN SMCFRKKTSC VRRRYSEFVW
LRHKLQDNAL LIELPKLPPW NPFFNLNNEF HITQRMQGLQ QFLEAVLQTP LLLSDSRLHL
FLQSQLSIAK MDACAQGHTH YTVAQAIQRC GGEARFPVEE QHQEDSKTCC DSDCDSTTSS
GLGCSIEPAT LVEQDLSHNE RFAHEFQATN PEAELCSSLS SSPHGHSVI
