SO1A2_HUMAN
ID SO1A2_HUMAN Reviewed; 670 AA.
AC P46721; Q9UGP7; Q9UL38;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Solute carrier organic anion transporter family member 1A2;
DE AltName: Full=OATP-A;
DE AltName: Full=Organic anion-transporting polypeptide 1;
DE Short=OATP-1;
DE AltName: Full=Sodium-independent organic anion transporter;
DE AltName: Full=Solute carrier family 21 member 3;
GN Name=SLCO1A2; Synonyms=OATP, OATP1, OATP1A2, SLC21A3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OATP1A).
RC TISSUE=Liver;
RX PubMed=7557095; DOI=10.1016/0016-5085(95)90588-x;
RA Kullak-Ublick G.-A., Hagenbuch B., Stieger B., Schteingart C.D.,
RA Hofmann A.F., Wolkoff A.W., Meier P.J.;
RT "Molecular and functional characterization of an organic anion transporting
RT polypeptide cloned from human liver.";
RL Gastroenterology 109:1274-1282(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM OATP1B).
RA Abe T., Kakyo M., Yawo H.;
RT "Isolation of human neural alternative form of organic anion transporter
RT subtype.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM OATP1A).
RX PubMed=10779507; DOI=10.1074/jbc.m001448200;
RA Koenig J., Cui Y., Nies A.T., Keppler D.;
RT "Localization and genomic organization of a new hepatocellular organic
RT anion transporting polypeptide.";
RL J. Biol. Chem. 275:23161-23168(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE (ISOFORM OATP1A).
RC TISSUE=Teratocarcinoma;
RX PubMed=11238933; DOI=10.1128/mcb.21.6.1973-1985.2001;
RA Speek M.;
RT "Antisense promoter of human L1 retrotransposon drives transcription of
RT adjacent cellular genes.";
RL Mol. Cell. Biol. 21:1973-1985(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE OF 1-20.
RA Kullak-Ublick G.-A.;
RT "Upstream region of the human organic anion transporting polypeptide A
RT (OATP-A) gene.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RX PubMed=17301733; DOI=10.1038/sj.clpt.6100104;
RA Bailey D.G., Dresser G.K., Leake B.F., Kim R.B.;
RT "Naringin is a major and selective clinical inhibitor of organic anion-
RT transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.";
RL Clin. Pharmacol. Ther. 81:495-502(2007).
RN [7]
RP VARIANTS THR-13; TYR-128; ILE-135; ASP-172; THR-187 AND SER-668.
RX PubMed=15632119; DOI=10.1074/jbc.m411092200;
RA Lee W., Glaeser H., Smith L.H., Roberts R.L., Moeckel G.W., Gervasini G.,
RA Leake B.F., Kim R.B.;
RT "Polymorphisms in human organic anion-transporting polypeptide 1A2
RT (OATP1A2): implications for altered drug disposition and central nervous
RT system drug entry.";
RL J. Biol. Chem. 280:9610-9617(2005).
RN [8]
RP VARIANT [LARGE SCALE ANALYSIS] ILE-220.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC such as sulfobromophthalein (BSP) and conjugated (taurocholate) and
CC unconjugated (cholate) bile acids (By similarity). Selectively
CC inhibited by the grapefruit juice component naringin. {ECO:0000250,
CC ECO:0000269|PubMed:17301733}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=OATP1a;
CC IsoId=P46721-1; Sequence=Displayed;
CC Name=OATP1b;
CC IsoId=P46721-2; Sequence=VSP_006130, VSP_006131, VSP_006132;
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; U21943; AAA87732.1; -; mRNA.
DR EMBL; AF085224; AAD52694.1; -; mRNA.
DR EMBL; AJ400735; CAB97006.1; -; Genomic_DNA.
DR EMBL; AJ400736; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400737; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400738; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400739; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400740; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400741; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400742; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400743; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400744; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400745; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400746; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400747; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AJ400748; CAB97006.1; JOINED; Genomic_DNA.
DR EMBL; AF279784; AAG30037.1; -; mRNA.
DR EMBL; Y08062; CAB64372.1; -; Genomic_DNA.
DR CCDS; CCDS8686.1; -. [P46721-1]
DR RefSeq; NP_066580.1; NM_021094.3. [P46721-1]
DR RefSeq; NP_602307.1; NM_134431.3. [P46721-1]
DR RefSeq; XP_005253531.1; XM_005253474.3. [P46721-1]
DR RefSeq; XP_011519120.1; XM_011520818.1. [P46721-1]
DR RefSeq; XP_011519121.1; XM_011520819.1. [P46721-1]
DR AlphaFoldDB; P46721; -.
DR SMR; P46721; -.
DR IntAct; P46721; 1.
DR STRING; 9606.ENSP00000305974; -.
DR BindingDB; P46721; -.
DR ChEMBL; CHEMBL1743123; -.
DR DrugBank; DB04630; Aldosterone.
DR DrugBank; DB00345; Aminohippuric acid.
DR DrugBank; DB01076; Atorvastatin.
DR DrugBank; DB14669; Betamethasone phosphate.
DR DrugBank; DB11591; Bilastine.
DR DrugBank; DB01222; Budesonide.
DR DrugBank; DB00887; Bumetanide.
DR DrugBank; DB00291; Chlorambucil.
DR DrugBank; DB02659; Cholic Acid.
DR DrugBank; DB00286; Conjugated estrogens.
DR DrugBank; DB01380; Cortisone acetate.
DR DrugBank; DB03619; Deoxycholic acid.
DR DrugBank; DB01234; Dexamethasone.
DR DrugBank; DB14649; Dexamethasone acetate.
DR DrugBank; DB09213; Dexibuprofen.
DR DrugBank; DB01396; Digitoxin.
DR DrugBank; DB00390; Digoxin.
DR DrugBank; DB00917; Dinoprostone.
DR DrugBank; DB00584; Enalapril.
DR DrugBank; DB00199; Erythromycin.
DR DrugBank; DB13952; Estradiol acetate.
DR DrugBank; DB13953; Estradiol benzoate.
DR DrugBank; DB13954; Estradiol cypionate.
DR DrugBank; DB13955; Estradiol dienanthate.
DR DrugBank; DB13956; Estradiol valerate.
DR DrugBank; DB04573; Estriol.
DR DrugBank; DB14641; Estriol tripropionate.
DR DrugBank; DB00655; Estrone.
DR DrugBank; DB00977; Ethinylestradiol.
DR DrugBank; DB01590; Everolimus.
DR DrugBank; DB00950; Fexofenadine.
DR DrugBank; DB01016; Glyburide.
DR DrugBank; DB02123; Glycochenodeoxycholic Acid.
DR DrugBank; DB02691; Glycocholic acid.
DR DrugBank; DB00741; Hydrocortisone.
DR DrugBank; DB14538; Hydrocortisone aceponate.
DR DrugBank; DB14539; Hydrocortisone acetate.
DR DrugBank; DB14540; Hydrocortisone butyrate.
DR DrugBank; DB14541; Hydrocortisone cypionate.
DR DrugBank; DB14542; Hydrocortisone phosphate.
DR DrugBank; DB14543; Hydrocortisone probutate.
DR DrugBank; DB14544; Hydrocortisone valerate.
DR DrugBank; DB01611; Hydroxychloroquine.
DR DrugBank; DB01050; Ibuprofen.
DR DrugBank; DB00224; Indinavir.
DR DrugBank; DB00328; Indomethacin.
DR DrugBank; DB01009; Ketoprofen.
DR DrugBank; DB01137; Levofloxacin.
DR DrugBank; DB00451; Levothyroxine.
DR DrugBank; DB11611; Lifitegrast.
DR DrugBank; DB00279; Liothyronine.
DR DrugBank; DB01583; Liotrix.
DR DrugBank; DB00227; Lovastatin.
DR DrugBank; DB00253; Medrysone.
DR DrugBank; DB00563; Methotrexate.
DR DrugBank; DB06710; Methyltestosterone.
DR DrugBank; DB08893; Mirabegron.
DR DrugBank; DB01183; Naloxone.
DR DrugBank; DB00788; Naproxen.
DR DrugBank; DB00220; Nelfinavir.
DR DrugBank; DB01092; Ouabain.
DR DrugBank; DB01708; Prasterone.
DR DrugBank; DB05804; Prasterone sulfate.
DR DrugBank; DB00175; Pravastatin.
DR DrugBank; DB00860; Prednisolone.
DR DrugBank; DB15566; Prednisolone acetate.
DR DrugBank; DB14631; Prednisolone phosphate.
DR DrugBank; DB00635; Prednisone.
DR DrugBank; DB01032; Probenecid.
DR DrugBank; DB00908; Quinidine.
DR DrugBank; DB00468; Quinine.
DR DrugBank; DB01045; Rifampicin.
DR DrugBank; DB11753; Rifamycin.
DR DrugBank; DB00503; Ritonavir.
DR DrugBank; DB00728; Rocuronium.
DR DrugBank; DB01098; Rosuvastatin.
DR DrugBank; DB01232; Saquinavir.
DR DrugBank; DB00641; Simvastatin.
DR DrugBank; DB00421; Spironolactone.
DR DrugBank; DB00669; Sumatriptan.
DR DrugBank; DB08833; Taurochenodeoxycholic acid.
DR DrugBank; DB04348; Taurocholic acid.
DR DrugBank; DB08834; Tauroursodeoxycholic acid.
DR DrugBank; DB08836; Temocapril.
DR DrugBank; DB13943; Testosterone cypionate.
DR DrugBank; DB13944; Testosterone enanthate.
DR DrugBank; DB13946; Testosterone undecanoate.
DR DrugBank; DB01124; Tolbutamide.
DR DrugBank; DB01586; Ursodeoxycholic acid.
DR DrugBank; DB00661; Verapamil.
DR DrugCentral; P46721; -.
DR GuidetoPHARMACOLOGY; 1219; -.
DR TCDB; 2.A.60.1.14; the organo anion transporter (oat) family.
DR GlyGen; P46721; 4 sites.
DR iPTMnet; P46721; -.
DR PhosphoSitePlus; P46721; -.
DR BioMuta; SLCO1A2; -.
DR DMDM; 1171882; -.
DR jPOST; P46721; -.
DR MassIVE; P46721; -.
DR PaxDb; P46721; -.
DR PeptideAtlas; P46721; -.
DR PRIDE; P46721; -.
DR Antibodypedia; 12308; 126 antibodies from 21 providers.
DR DNASU; 6579; -.
DR Ensembl; ENST00000307378.10; ENSP00000305974.6; ENSG00000084453.17. [P46721-1]
DR Ensembl; ENST00000683939.1; ENSP00000508235.1; ENSG00000084453.17. [P46721-1]
DR GeneID; 6579; -.
DR KEGG; hsa:6579; -.
DR MANE-Select; ENST00000683939.1; ENSP00000508235.1; NM_001386879.1; NP_001373808.1.
DR UCSC; uc001res.3; human. [P46721-1]
DR CTD; 6579; -.
DR DisGeNET; 6579; -.
DR GeneCards; SLCO1A2; -.
DR HGNC; HGNC:10956; SLCO1A2.
DR HPA; ENSG00000084453; Tissue enhanced (brain, choroid plexus).
DR MIM; 602883; gene.
DR neXtProt; NX_P46721; -.
DR OpenTargets; ENSG00000084453; -.
DR PharmGKB; PA328; -.
DR VEuPathDB; HostDB:ENSG00000084453; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244856; -.
DR HOGENOM; CLU_008954_4_0_1; -.
DR InParanoid; P46721; -.
DR OMA; DCNMDCN; -.
DR PhylomeDB; P46721; -.
DR TreeFam; TF317540; -.
DR PathwayCommons; P46721; -.
DR Reactome; R-HSA-159418; Recycling of bile acids and salts.
DR Reactome; R-HSA-879518; Transport of organic anions.
DR SignaLink; P46721; -.
DR BioGRID-ORCS; 6579; 15 hits in 1069 CRISPR screens.
DR ChiTaRS; SLCO1A2; human.
DR GeneWiki; SLCO1A2; -.
DR GenomeRNAi; 6579; -.
DR Pharos; P46721; Tchem.
DR PRO; PR:P46721; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; P46721; protein.
DR Bgee; ENSG00000084453; Expressed in C1 segment of cervical spinal cord and 112 other tissues.
DR ExpressionAtlas; P46721; baseline and differential.
DR Genevisible; P46721; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0015711; P:organic anion transport; TAS:ProtInc.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..670
FT /note="Solute carrier organic anion transporter family
FT member 1A2"
FT /id="PRO_0000191042"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..353
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..377
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..405
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..513
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..536
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..545
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..571
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 572..605
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 606..623
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..670
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 433..488
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 412
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 439..469
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 445..465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 454..486
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VAR_SEQ 1..19
FT /note="MGETEKRIETHRIRCLSKL -> MFLTKNCKQEQERVESA (in isoform
FT OATP1b)"
FT /evidence="ECO:0000305"
FT /id="VSP_006130"
FT VAR_SEQ 559..581
FT /note="AGIPAPIYFGALMDSTCLHWGTL -> GKNSYFFPHPIRTILLLLFFITL
FT (in isoform OATP1b)"
FT /evidence="ECO:0000305"
FT /id="VSP_006131"
FT VAR_SEQ 582..670
FT /note="Missing (in isoform OATP1b)"
FT /evidence="ECO:0000305"
FT /id="VSP_006132"
FT VARIANT 13
FT /note="I -> T (in dbSNP:rs10841795)"
FT /evidence="ECO:0000269|PubMed:15632119"
FT /id="VAR_024644"
FT VARIANT 128
FT /note="N -> Y (in dbSNP:rs11568567)"
FT /evidence="ECO:0000269|PubMed:15632119"
FT /id="VAR_020289"
FT VARIANT 135
FT /note="N -> I (in dbSNP:rs45502302)"
FT /evidence="ECO:0000269|PubMed:15632119"
FT /id="VAR_020290"
FT VARIANT 172
FT /note="E -> D (in dbSNP:rs11568563)"
FT /evidence="ECO:0000269|PubMed:15632119"
FT /id="VAR_020291"
FT VARIANT 187
FT /note="A -> T (in dbSNP:rs750165758)"
FT /evidence="ECO:0000269|PubMed:15632119"
FT /id="VAR_036823"
FT VARIANT 220
FT /note="V -> I (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036409"
FT VARIANT 355
FT /note="I -> V (in dbSNP:rs45628437)"
FT /id="VAR_020292"
FT VARIANT 668
FT /note="T -> S (in dbSNP:rs11568557)"
FT /evidence="ECO:0000269|PubMed:15632119"
FT /id="VAR_020293"
SQ SEQUENCE 670 AA; 74145 MW; C3A740CEF1E6F129 CRC64;
MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ FNIPTSLVGF
INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC FLKSLPHFLM NQYEYESTVS
VSGNLSSNSF LCMENGTQIL RPTQDPSECT KEVKSLMWVY VLVGNIVRGM GETPILPLGI
SYIEDFAKFE NSPLYIGLVE TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR
WVGAWWFGFL ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG
ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS SSDAIFLMGI
YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL LYFLSFLMTC ENSSVVGINT
SYEGIPQDLY VENDIFADCN VDCNCPSKIW DPVCGNNGLS YLSACLAGCE TSIGTGINMV
FQNCSCIQTS GNSSAVLGLC DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK
SEEKSLGVGL HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI
YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE CKDIYQKSTV
LKDDELKTKL
