SO1A4_MOUSE
ID SO1A4_MOUSE Reviewed; 670 AA.
AC Q9EP96;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Solute carrier organic anion transporter family member 1A4;
DE AltName: Full=Sodium-independent organic anion-transporting polypeptide 2;
DE AltName: Full=Solute carrier family 21 member 5;
GN Name=Slco1a4; Synonyms=Oatp1a4, Oatp2, Slc21a5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND ALTERNATIVE SPLICING.
RC STRAIN=129/SvJ, and BALB/cJ; TISSUE=Liver;
RX PubMed=11181066; DOI=10.1006/bbrc.2001.4387;
RA Ogura K., Choudhuri S., Klaassen C.D.;
RT "Genomic organization and tissue-specific expression of splice variants of
RT mouse organic anion transporting polypeptide 2.";
RL Biochem. Biophys. Res. Commun. 281:431-439(2001).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-
CC 3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid
CC hormones. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=3 isoforms are produced.;
CC Name=1;
CC IsoId=Q9EP96-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Highly expressed in brain and liver. Detected at
CC very low levels in heart and lung.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; AB043023; BAB18305.1; -; Genomic_DNA.
DR EMBL; AB031814; BAB12445.1; -; mRNA.
DR CCDS; CCDS39690.1; -. [Q9EP96-1]
DR PIR; JC7616; JC7616.
DR RefSeq; NP_109612.1; NM_030687.1. [Q9EP96-1]
DR RefSeq; XP_006507023.1; XM_006506960.3.
DR RefSeq; XP_011239886.1; XM_011241584.2. [Q9EP96-1]
DR RefSeq; XP_011239887.1; XM_011241585.2. [Q9EP96-1]
DR RefSeq; XP_011239888.1; XM_011241586.2. [Q9EP96-1]
DR AlphaFoldDB; Q9EP96; -.
DR SMR; Q9EP96; -.
DR STRING; 10090.ENSMUSP00000130746; -.
DR ChEMBL; CHEMBL2073700; -.
DR TCDB; 2.A.60.1.6; the organo anion transporter (oat) family.
DR GlyGen; Q9EP96; 4 sites.
DR iPTMnet; Q9EP96; -.
DR PhosphoSitePlus; Q9EP96; -.
DR jPOST; Q9EP96; -.
DR MaxQB; Q9EP96; -.
DR PaxDb; Q9EP96; -.
DR PRIDE; Q9EP96; -.
DR ProteomicsDB; 261307; -. [Q9EP96-1]
DR DNASU; 28250; -.
DR Ensembl; ENSMUST00000032364; ENSMUSP00000032364; ENSMUSG00000030237. [Q9EP96-1]
DR Ensembl; ENSMUST00000165990; ENSMUSP00000130746; ENSMUSG00000030237. [Q9EP96-1]
DR GeneID; 28250; -.
DR KEGG; mmu:28250; -.
DR UCSC; uc009eos.1; mouse. [Q9EP96-1]
DR CTD; 28250; -.
DR MGI; MGI:1351896; Slco1a4.
DR VEuPathDB; HostDB:ENSMUSG00000030237; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244856; -.
DR HOGENOM; CLU_008954_4_0_1; -.
DR InParanoid; Q9EP96; -.
DR OMA; HFLMDRX; -.
DR OrthoDB; 1029129at2759; -.
DR PhylomeDB; Q9EP96; -.
DR TreeFam; TF317540; -.
DR Reactome; R-MMU-159418; Recycling of bile acids and salts.
DR Reactome; R-MMU-879518; Transport of organic anions.
DR BioGRID-ORCS; 28250; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Slco1a4; mouse.
DR PRO; PR:Q9EP96; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EP96; protein.
DR Bgee; ENSMUSG00000030237; Expressed in pigmented layer of retina and 107 other tissues.
DR ExpressionAtlas; Q9EP96; baseline and differential.
DR Genevisible; Q9EP96; MM.
DR GO; GO:0009925; C:basal plasma membrane; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; ISO:MGI.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IDA:MGI.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IDA:MGI.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; ISO:MGI.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..670
FT /note="Solute carrier organic anion transporter family
FT member 1A4"
FT /id="PRO_0000191046"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..353
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..377
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..405
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..513
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..536
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..545
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..571
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 572..605
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 606..623
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..670
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 433..488
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 649..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 634
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P46720"
FT MOD_RES 635
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P46720"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 483
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 492
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 439..469
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 445..465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 454..486
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ SEQUENCE 670 AA; 73965 MW; 65EFDD16F641F04F CRC64;
MGKSEKEVAT HGVRCFSKIK AFLLALTCAY VSKSLSGTYM NSMLTQIERQ FGIPTSVVGL
INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCAVMGLGC FLISIPHFLM GRYEYETTIL
PTSNLSSNSF VCTENRTQTL KPTQDPTECV KEMKSLMWIY VLVGNIIRGM GETPIMPLGI
SYIEDFAKSE NSPLYIGILE TGMTIGPLIG LLLGSSCANI YVDTGSVNTD DLTITPTDTR
WVGAWWIGFL VCAGVNILTS IPFFFFPKTL LKEGLQDNGD GTENAKEEKH REKIKEENRG
ITKDFFLFMK SLSCNPIYMI FILISVIQVN AFINSFTFMP KYLEQQYGKS TAEIVFLMGL
YMLPPICLGY LIGGLIMKKF KITVKKAAYI GFWLSLTEYL LSFVSYIMTC DNFPVAGLTT
SYEGVQHPLY VENNVLADCN TKCSCLTNTW DPVCGDNGLS YMSACLAGCE KSVGTGTNMV
FQNCSCIQSS GNASAVLGLC DKGPECANKL QYFLIISIIG CFIFSLGAIP GYMVLLRCMK
SEEKSLGVGL HTFCMRILGG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYDINSFRRI
YLGLPAALRG ASFLPALFIL ILMRKFQFPG DIDSSDTDPA EMKLTAKESK CTNVHRSPTM
QNDGERKTKL
