SO1A5_MOUSE
ID SO1A5_MOUSE Reviewed; 670 AA.
AC Q91YY5; Q91XS2;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 150.
DE RecName: Full=Solute carrier organic anion transporter family member 1A5;
DE AltName: Full=Organic anion-transporting polypeptide 3;
DE Short=OATP-3;
DE AltName: Full=Sodium-independent organic anion transporter 3;
DE AltName: Full=Solute carrier family 21 member 7;
GN Name=Slco1a5; Synonyms=Oatp1a5, Oatp3, Slc21a7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=11093941; DOI=10.1152/ajpgi.2000.279.6.g1188;
RA Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.;
RT "Expression, transport properties, and chromosomal location of organic
RT anion transporter subtype 3.";
RL Am. J. Physiol. 279:G1188-G1200(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC such as taurocholate and thyroid hormones. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; AF240694; AAK39416.1; -; mRNA.
DR EMBL; BC013594; AAH13594.1; -; mRNA.
DR CCDS; CCDS57464.1; -.
DR RefSeq; NP_001254636.1; NM_001267707.1.
DR RefSeq; NP_570931.1; NM_130861.3.
DR AlphaFoldDB; Q91YY5; -.
DR SMR; Q91YY5; -.
DR STRING; 10090.ENSMUSP00000080116; -.
DR GlyGen; Q91YY5; 4 sites.
DR iPTMnet; Q91YY5; -.
DR PhosphoSitePlus; Q91YY5; -.
DR jPOST; Q91YY5; -.
DR MaxQB; Q91YY5; -.
DR PaxDb; Q91YY5; -.
DR PRIDE; Q91YY5; -.
DR ProteomicsDB; 261308; -.
DR DNASU; 108096; -.
DR GeneID; 108096; -.
DR KEGG; mmu:108096; -.
DR UCSC; uc009epa.2; mouse.
DR CTD; 108096; -.
DR MGI; MGI:1351865; Slco1a5.
DR eggNOG; KOG3626; Eukaryota.
DR InParanoid; Q91YY5; -.
DR OrthoDB; 1029129at2759; -.
DR PhylomeDB; Q91YY5; -.
DR TreeFam; TF317540; -.
DR BioGRID-ORCS; 108096; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Slco1a5; mouse.
DR PRO; PR:Q91YY5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q91YY5; protein.
DR GO; GO:0031526; C:brush border membrane; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; ISO:MGI.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; ISO:MGI.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; ISO:MGI.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; ISO:MGI.
DR GO; GO:0015721; P:bile acid and bile salt transport; ISO:MGI.
DR GO; GO:0050892; P:intestinal absorption; ISO:MGI.
DR GO; GO:0015718; P:monocarboxylic acid transport; ISO:MGI.
DR GO; GO:0015711; P:organic anion transport; ISO:MGI.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..670
FT /note="Solute carrier organic anion transporter family
FT member 1A5"
FT /id="PRO_0000191043"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..353
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..377
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..405
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..513
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..536
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..545
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..571
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 572..605
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 606..623
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..670
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 433..488
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 483
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 492
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 439..469
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 445..465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 454..486
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT CONFLICT 280
FT /note="A -> D (in Ref. 1; AAK39416)"
FT /evidence="ECO:0000305"
FT CONFLICT 591
FT /note="I -> M (in Ref. 1; AAK39416)"
FT /evidence="ECO:0000305"
FT CONFLICT 644
FT /note="Q -> L (in Ref. 1; AAK39416)"
FT /evidence="ECO:0000305"
FT CONFLICT 656
FT /note="G -> R (in Ref. 1; AAK39416)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 670 AA; 74663 MW; AF802A903FCD457D CRC64;
MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ FDIPTSIVGL
INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC FLMSLPHFLM GRYEYETTIS
PTSNLSSNSF LCMENRTQTL KPTQDPAECV KEMKSLMWIY VLVGNIIRGI GETPIMPLGI
SYIEDFAKSE NSPLYIGILE SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR
WVGAWWIGFL VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TSEVVLLIGV
CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL LSYFHFMISC DNFQVAGLTT
SYEGVQHPLY VENKVLADCN TRCSCLTNTW DPVCGDNGLS YMSACLAGCE KSVGMGTHMV
FQNCSCIQSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK
SEEKSLGIGL HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI
YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE CTDVHGIPKV
ENDGELKTKL
