SO1A5_RAT
ID SO1A5_RAT Reviewed; 670 AA.
AC O88397; Q9EQR8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Solute carrier organic anion transporter family member 1A5;
DE AltName: Full=Organic anion-transporting polypeptide 3;
DE Short=OATP-3;
DE AltName: Full=Sodium-independent organic anion transporter 3;
DE AltName: Full=Solute carrier family 21 member 7;
GN Name=Slco1a5; Synonyms=Oatp1a5, Oatp3, Slc21a7, Slco1a2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=9712861; DOI=10.1074/jbc.273.35.22395;
RA Abe T., Kakyo M., Sakagami H., Tokui T., Nishio T., Tanemoto M., Nomura H.,
RA Hebert S.C., Matsuno S., Kondo H., Yawo H.;
RT "Molecular characterization and tissue distribution of a new organic anion
RT transporter subtype (oatp3) that transports thyroid hormones and
RT taurocholate and comparison with oatp2.";
RL J. Biol. Chem. 273:22395-22401(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Ileum;
RX PubMed=11093941; DOI=10.1152/ajpgi.2000.279.6.g1188;
RA Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.;
RT "Expression, transport properties, and chromosomal location of organic
RT anion transporter subtype 3.";
RL Am. J. Physiol. 279:G1188-G1200(2000).
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC such as taurocholate and thyroid hormones.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in the kidney and moderately
CC abundant in the retina.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; AF041105; AAC32804.1; -; mRNA.
DR EMBL; AF083469; AAG36719.1; -; mRNA.
DR RefSeq; NP_110465.1; NM_030838.1.
DR RefSeq; XP_006237704.1; XM_006237642.2.
DR RefSeq; XP_006237705.1; XM_006237643.2.
DR RefSeq; XP_006237708.1; XM_006237646.2.
DR RefSeq; XP_008761654.1; XM_008763432.1.
DR RefSeq; XP_017448393.1; XM_017592904.1.
DR RefSeq; XP_017448394.1; XM_017592905.1.
DR AlphaFoldDB; O88397; -.
DR SMR; O88397; -.
DR STRING; 10116.ENSRNOP00000048288; -.
DR ChEMBL; CHEMBL2073692; -.
DR TCDB; 2.A.60.1.3; the organo anion transporter (oat) family.
DR GlyGen; O88397; 4 sites.
DR PaxDb; O88397; -.
DR GeneID; 80900; -.
DR KEGG; rno:80900; -.
DR UCSC; RGD:70985; rat.
DR CTD; 108096; -.
DR RGD; 70985; Slco1a5.
DR VEuPathDB; HostDB:ENSRNOG00000047493; -.
DR eggNOG; KOG3626; Eukaryota.
DR HOGENOM; CLU_008954_4_0_1; -.
DR InParanoid; O88397; -.
DR OMA; DCNMDCN; -.
DR OrthoDB; 1029129at2759; -.
DR PhylomeDB; O88397; -.
DR TreeFam; TF317540; -.
DR PRO; PR:O88397; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000031249; Expressed in lung and 6 other tissues.
DR Genevisible; O88397; RN.
DR GO; GO:0031526; C:brush border membrane; IDA:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IDA:RGD.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IDA:RGD.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IDA:RGD.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; IDA:RGD.
DR GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
DR GO; GO:0015721; P:bile acid and bile salt transport; IDA:RGD.
DR GO; GO:0050892; P:intestinal absorption; IMP:RGD.
DR GO; GO:0015718; P:monocarboxylic acid transport; IMP:RGD.
DR GO; GO:0015711; P:organic anion transport; IDA:RGD.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..670
FT /note="Solute carrier organic anion transporter family
FT member 1A5"
FT /id="PRO_0000191044"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..353
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..377
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..405
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..513
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..536
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..545
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..571
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 572..605
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 606..623
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..670
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 433..488
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 483
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 492
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 439..469
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 445..465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 454..486
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT CONFLICT 33
FT /note="K -> Q (in Ref. 1; AAC32804)"
FT /evidence="ECO:0000305"
FT CONFLICT 55
FT /note="T -> I (in Ref. 1; AAC32804)"
FT /evidence="ECO:0000305"
FT CONFLICT 70
FT /note="L -> F (in Ref. 1; AAC32804)"
FT /evidence="ECO:0000305"
FT CONFLICT 421
FT /note="S -> L (in Ref. 1; AAC32804)"
FT /evidence="ECO:0000305"
FT CONFLICT 543
FT /note="E -> K (in Ref. 1; AAC32804)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 670 AA; 74577 MW; 17BA60B86E0B567A CRC64;
MGETEKRVAT HEVRCFSKIK MFLLALTWAY VSKSLSGIYM NTMLTQIERQ FDIPTSIVGF
INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCVIMGLGC FLMSLPHFLM GRYEYETTIS
PTSNLSSNSF LCMENRSQTL KPTQDPAECI KEMKSLMWIY VLVGNIIRGI GETPIMPLGI
SYIEDFAKSE NSPLYIGILE TGKVFGPIVG LLLGSFCASI YVDTGSVNTD DLTITPTDTR
WVGAWWIGFL ICAGVNILSS IPFFFFPKTL PKEGLQDDVD GTNNDKEEKH REKAKEENRG
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TAEVVLLIGV
YNLPPICIGY LLIGFIMKKF KITVKKAAYM AFCLSLFEYL LYFLHFMITC DNFPVAGLTA
SYEGVHHPLY VENKVLADCN RGCSCSTNSW DPVCGDNGLA YMSACLAGCK KSVGTGTNMV
FQNCSCIRSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK
PEEKSLGIGL HAFCTRVFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYNINNFRRI
YLVLPAALRG SSYLPALFIL ILMRKFQFPG EIDSSETELA EMKITVKKSE CTDVHGSPQV
ENDGELKTRL
