SO1A6_RAT
ID SO1A6_RAT Reviewed; 670 AA.
AC Q9QYE2;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Solute carrier organic anion transporter family member 1A6;
DE AltName: Full=Kidney-specific organic anion-transporting polypeptide 5;
DE Short=OATP-5;
DE AltName: Full=Solute carrier family 21 member 13;
GN Name=Slco1a6; Synonyms=Oatp5, Slc21a13;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Kidney;
RA Cattori V., Hagenbuch B., Stieger B., Winterhalter K.H., Meier P.J.;
RT "Cloning of a new member of the oatp family from rat kidney.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May mediate the Na(+)-independent transport of organic
CC anions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; AF053317; AAF21711.2; -; mRNA.
DR RefSeq; NP_570092.1; NM_130736.1.
DR RefSeq; XP_017448409.1; XM_017592920.1.
DR RefSeq; XP_017448410.1; XM_017592921.1.
DR RefSeq; XP_017448411.1; XM_017592922.1.
DR AlphaFoldDB; Q9QYE2; -.
DR SMR; Q9QYE2; -.
DR STRING; 10116.ENSRNOP00000039792; -.
DR GlyGen; Q9QYE2; 4 sites.
DR PaxDb; Q9QYE2; -.
DR GeneID; 84608; -.
DR KEGG; rno:84608; -.
DR UCSC; RGD:69304; rat.
DR CTD; 28254; -.
DR RGD; 69304; Slco1a6.
DR VEuPathDB; HostDB:ENSRNOG00000030894; -.
DR eggNOG; KOG3626; Eukaryota.
DR HOGENOM; CLU_008954_4_0_1; -.
DR InParanoid; Q9QYE2; -.
DR OMA; MSECLLS; -.
DR OrthoDB; 1029129at2759; -.
DR PhylomeDB; Q9QYE2; -.
DR TreeFam; TF317540; -.
DR PRO; PR:Q9QYE2; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000030894; Expressed in kidney and 5 other tissues.
DR Genevisible; Q9QYE2; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..670
FT /note="Solute carrier organic anion transporter family
FT member 1A6"
FT /id="PRO_0000191049"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..353
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..377
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..405
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..513
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..536
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..545
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..571
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 572..605
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 606..623
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..670
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 433..488
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 276..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 634
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99J94"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 492
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 439..469
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 445..465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 454..486
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ SEQUENCE 670 AA; 74451 MW; E850B5DAD37FBE88 CRC64;
MGEPEKRAGT HGIRCFAKIK VFLLALTWAY ASKALSATYM NSMLTQIERR FNISTSIVGL
INGSFEVGNL LLIIFVSYFG RKRHRPIMIG IGCAVMGLGC FIISLPHFLM GRYEYETTIS
PTSNLSSNSF LCMENRTQTL KPTQDPAECV KEMKSLMWIY VLVGNIIRGI GETPIMPLGI
SYIEDFAKSE NSPFYIGILE VGKITGPIAA IWLGSFCATI YVDMGSVNTD DLTITPTDTR
CVGAWWIGFL VCAGLNILIS IPFFFFPKTF PKEGPEDMAN ETKNDEGDKH REKAKEEKRG
ITKDFFLFMK SLSCNPIYML CVLTSVLQVN GFVSIFTFKP KYLEHHYGKS SSEAIFLMGL
YTLPSVCVGY LISGFIMKKF KITLKKAAFI SYCLGMSECL LSLCNFMLTC DNVPIAGLTT
SYEGIQQSFD MENTVLADCN TRCSCLTKTW DPVCGDNGLA YITPCLAGCE KSVGSGINMV
LQDCSCIQSS GNSSAVLGLC NKGPDCANKL QYFLIITVFC SFFYSLSLIP GYMIFLRCMK
SEEKSLGIGL QAFCMRILGG ILAPIYFGVL IDRTCLHWGT QKCGEPGACR TYEINSFRSI
YLGLPAALRG SSYLPAFFIL RLMRKFQFPG DINSPVTDHV EMMLTEKESE HTDVHRSPQV
ENDGELKTKL
