SO1B1_HUMAN
ID SO1B1_HUMAN Reviewed; 691 AA.
AC Q9Y6L6; B2R7G2; Q29R64; Q9NQ37; Q9UBF3; Q9UH89;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Solute carrier organic anion transporter family member 1B1;
DE AltName: Full=Liver-specific organic anion transporter 1;
DE Short=LST-1;
DE AltName: Full=OATP-C;
DE AltName: Full=Sodium-independent organic anion-transporting polypeptide 2;
DE Short=OATP-2;
DE AltName: Full=Solute carrier family 21 member 6;
GN Name=SLCO1B1; Synonyms=LST1, OATP1B1, OATP2, OATPC, SLC21A6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND VARIANTS
RP LYS-152 AND ASN-241.
RC TISSUE=Liver;
RX PubMed=10358072; DOI=10.1074/jbc.274.24.17159;
RA Abe T., Kakyo M., Tokui T., Nakagomi R., Nishio T., Nakai D., Nomura H.,
RA Unno M., Suzuki M., Naitoh T., Matsuno S., Yawo H.;
RT "Identification of a novel gene family encoding human liver-specific
RT organic anion transporter LST-1.";
RL J. Biol. Chem. 274:17159-17163(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND VARIANT
RP ASP-130.
RC TISSUE=Liver;
RX PubMed=10601278; DOI=10.1074/jbc.274.52.37161;
RA Hsiang B.H., Zhu Y., Wang Z., Wu Y., Sasseville V., Yang W.-P.,
RA Kirchgessner T.G.;
RT "A novel human hepatic organic anion transporting polypeptide (OATP2).
RT Identification of a liver-specific human organic anion transporting
RT polypeptide and identification of rat and human hydroxymethylglutaryl-CoA
RT reductase inhibitor transporters.";
RL J. Biol. Chem. 274:37161-37168(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=10644574; DOI=10.1152/ajpgi.2000.278.1.g156;
RA Koenig J., Cui Y., Nies A.T., Keppler D.;
RT "A novel human organic anion transporting polypeptide localized to the
RT basolateral hepatocyte membrane.";
RL Am. J. Physiol. 278:G156-G164(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Nezu J.;
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10779507; DOI=10.1074/jbc.m001448200;
RA Koenig J., Cui Y., Nies A.T., Keppler D.;
RT "Localization and genomic organization of a new hepatocellular organic
RT anion transporting polypeptide.";
RL J. Biol. Chem. 275:23161-23168(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASP-130.
RG SeattleSNPs variation discovery resource;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASP-130 AND THR-155.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP FUNCTION, TISSUE SPECIFICITY, AND INVOLVEMENT IN HBLRR.
RX PubMed=22232210; DOI=10.1172/jci59526;
RA van de Steeg E., Stranecky V., Hartmannova H., Noskova L., Hrebicek M.,
RA Wagenaar E., van Esch A., de Waart D.R., Oude Elferink R.P.,
RA Kenworthy K.E., Sticova E., al-Edreesi M., Knisely A.S., Kmoch S.,
RA Jirsa M., Schinkel A.H.;
RT "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by
RT interrupting conjugated bilirubin reuptake into the liver.";
RL J. Clin. Invest. 122:519-528(2012).
RN [11]
RP GLYCOSYLATION AT ASN-134; ASN-503 AND ASN-516.
RX PubMed=23285087; DOI=10.1371/journal.pone.0052563;
RA Yao J., Hong W., Huang J., Zhan K., Huang H., Hong M.;
RT "N-Glycosylation dictates proper processing of organic anion transporting
RT polypeptide 1B1.";
RL PLoS ONE 7:E52563-E52563(2012).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; SER-295; SER-672 AND
RP SER-682, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [13]
RP VARIANTS LEU-73; ALA-82; ASP-130; LYS-152; THR-155; GLY-156; ALA-174;
RP ASN-241; THR-353; ASP-432; GLY-462; ALA-488; GLY-655 AND GLY-667, AND
RP CHARACTERIZATION.
RX PubMed=11477075; DOI=10.1074/jbc.m103792200;
RA Tirona R.G., Leake B.F., Merino G., Kim R.B.;
RT "Polymorphisms in OATP-C: identification of multiple allelic variants
RT associated with altered transport activity among European- and African-
RT Americans.";
RL J. Biol. Chem. 276:35669-35675(2001).
RN [14]
RP CHARACTERIZATION OF VARIANTS ASP-130; THR-155 AND ARG-193, FUNCTION, AND
RP SUBCELLULAR LOCATION.
RX PubMed=12196548; DOI=10.1074/jbc.m207735200;
RA Michalski C., Cui Y., Nies A.T., Nuessler A.K., Neuhaus P., Zanger U.M.,
RA Klein K., Eichelbaum M., Keppler D., Koenig J.;
RT "A naturally occurring mutation in the SLC21A6 gene causing impaired
RT membrane localization of the hepatocyte uptake transporter.";
RL J. Biol. Chem. 277:43058-43063(2002).
RN [15]
RP VARIANTS ASP-130; LYS-152; ALA-174 AND ASN-241.
RX PubMed=12130747; DOI=10.1124/jpet.302.2.804;
RA Nozawa T., Nakajima M., Tamai I., Noda K., Nezu J., Sai Y., Tsuji A.,
RA Yokoi T.;
RT "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6)
RT and OATP-B (SLC21A9): allele frequencies in the Japanese population and
RT functional analysis.";
RL J. Pharmacol. Exp. Ther. 302:804-813(2002).
CC -!- FUNCTION: Mediates the Na(+)-independent uptake of organic anions such
CC as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone
CC sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin
CC E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and
CC triiodothyronine. Involved in the clearance of bile acids and organic
CC anions from the liver. {ECO:0000269|PubMed:10358072,
CC ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:12196548,
CC ECO:0000269|PubMed:22232210}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000269|PubMed:12196548}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12196548}. Note=Detected in basolateral membranes
CC of hepatocytes.
CC -!- TISSUE SPECIFICITY: Highly expressed in liver, at the basolateral
CC membranes of centrilobular hepatocytes. Not detected in heart, brain,
CC placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus,
CC prostate, testis, ovary, small intestine, colon and leukocyte.
CC {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278,
CC ECO:0000269|PubMed:22232210}.
CC -!- DISEASE: Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An
CC autosomal recessive form of primary conjugated hyperbilirubinemia.
CC Affected individuals develop mild jaundice not associated with
CC hemolysis shortly after birth or in childhood. They have delayed plasma
CC clearance of the unconjugated anionic dye bromsulphthalein and
CC prominent urinary excretion of coproporphyrin I. Hepatic pigmentation
CC is normal. {ECO:0000269|PubMed:22232210}. Note=The disease is caused by
CC variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/slco1b1/";
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DR EMBL; AF060500; AAD38323.1; -; mRNA.
DR EMBL; AF205071; AAF20212.1; -; mRNA.
DR EMBL; AJ132573; CAB62577.1; -; mRNA.
DR EMBL; AB026257; BAA78639.1; -; mRNA.
DR EMBL; AJ400749; CAB97007.1; -; Genomic_DNA.
DR EMBL; AJ400750; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400751; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400752; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400753; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400754; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400755; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400756; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400757; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400758; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400759; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400760; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400761; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AJ400762; CAB97007.1; JOINED; Genomic_DNA.
DR EMBL; AY945934; AAX20114.1; -; Genomic_DNA.
DR EMBL; AK312970; BAG35809.1; -; mRNA.
DR EMBL; CH471094; EAW96420.1; -; Genomic_DNA.
DR EMBL; BC114376; AAI14377.1; -; mRNA.
DR CCDS; CCDS8685.1; -.
DR RefSeq; NP_006437.3; NM_006446.4.
DR AlphaFoldDB; Q9Y6L6; -.
DR SMR; Q9Y6L6; -.
DR BioGRID; 115847; 15.
DR IntAct; Q9Y6L6; 9.
DR STRING; 9606.ENSP00000256958; -.
DR BindingDB; Q9Y6L6; -.
DR ChEMBL; CHEMBL1697668; -.
DR DrugBank; DB06151; Acetylcysteine.
DR DrugBank; DB06403; Ambrisentan.
DR DrugBank; DB00345; Aminohippuric acid.
DR DrugBank; DB00701; Amprenavir.
DR DrugBank; DB11901; Apalutamide.
DR DrugBank; DB09274; Artesunate.
DR DrugBank; DB12597; Asciminib.
DR DrugBank; DB11586; Asunaprevir.
DR DrugBank; DB01072; Atazanavir.
DR DrugBank; DB16098; Atogepant.
DR DrugBank; DB01076; Atorvastatin.
DR DrugBank; DB06626; Axitinib.
DR DrugBank; DB08857; Bamet-UD2.
DR DrugBank; DB00394; Beclomethasone dipropionate.
DR DrugBank; DB15719; Belantamab mafodotin.
DR DrugBank; DB16703; Belumosudil.
DR DrugBank; DB15463; Belzutifan.
DR DrugBank; DB11936; Bempedoic acid.
DR DrugBank; DB12319; Benzbromarone.
DR DrugBank; DB01053; Benzylpenicillin.
DR DrugBank; DB01393; Bezafibrate.
DR DrugBank; DB12151; Brincidofovir.
DR DrugBank; DB06772; Cabazitaxel.
DR DrugBank; DB13919; Candesartan.
DR DrugBank; DB00520; Caspofungin.
DR DrugBank; DB00439; Cerivastatin.
DR DrugBank; DB08862; Cholecystokinin.
DR DrugBank; DB02659; Cholic Acid.
DR DrugBank; DB08858; cis-Diamminechlorocholylglycinateplatinum(II).
DR DrugBank; DB01211; Clarithromycin.
DR DrugBank; DB00257; Clotrimazole.
DR DrugBank; DB09065; Cobicistat.
DR DrugBank; DB05239; Cobimetinib.
DR DrugBank; DB00286; Conjugated estrogens.
DR DrugBank; DB00091; Cyclosporine.
DR DrugBank; DB08912; Dabrafenib.
DR DrugBank; DB09102; Daclatasvir.
DR DrugBank; DB08856; DADLE.
DR DrugBank; DB12941; Darolutamide.
DR DrugBank; DB01264; Darunavir.
DR DrugBank; DB00509; Dextrothyroxine.
DR DrugBank; DB00586; Diclofenac.
DR DrugBank; DB00255; Diethylstilbestrol.
DR DrugBank; DB00390; Digoxin.
DR DrugBank; DB00917; Dinoprostone.
DR DrugBank; DB08995; Diosmin.
DR DrugBank; DB00975; Dipyridamole.
DR DrugBank; DB05928; Dovitinib.
DR DrugBank; DB04855; Dronedarone.
DR DrugBank; DB11979; Elagolix.
DR DrugBank; DB15444; Elexacaftor.
DR DrugBank; DB06210; Eltrombopag.
DR DrugBank; DB09272; Eluxadoline.
DR DrugBank; DB09038; Empagliflozin.
DR DrugBank; DB13874; Enasidenib.
DR DrugBank; DB00199; Erythromycin.
DR DrugBank; DB00783; Estradiol.
DR DrugBank; DB13952; Estradiol acetate.
DR DrugBank; DB13953; Estradiol benzoate.
DR DrugBank; DB13954; Estradiol cypionate.
DR DrugBank; DB13955; Estradiol dienanthate.
DR DrugBank; DB13956; Estradiol valerate.
DR DrugBank; DB00655; Estrone.
DR DrugBank; DB01590; Everolimus.
DR DrugBank; DB00973; Ezetimibe.
DR DrugBank; DB12500; Fedratinib.
DR DrugBank; DB12265; Fexinidazole.
DR DrugBank; DB00950; Fexofenadine.
DR DrugBank; DB09279; Fimasartan.
DR DrugBank; DB13867; Fluticasone.
DR DrugBank; DB08906; Fluticasone furoate.
DR DrugBank; DB00588; Fluticasone propionate.
DR DrugBank; DB01095; Fluvastatin.
DR DrugBank; DB11796; Fostemsavir.
DR DrugBank; DB02703; Fusidic acid.
DR DrugBank; DB08884; Gadoxetic acid.
DR DrugBank; DB01241; Gemfibrozil.
DR DrugBank; DB01645; Genistein.
DR DrugBank; DB06721; Gimatecan.
DR DrugBank; DB13879; Glecaprevir.
DR DrugBank; DB02691; Glycocholic acid.
DR DrugBank; DB11575; Grazoprevir.
DR DrugBank; DB01892; Hyperforin.
DR DrugBank; DB09054; Idelalisib.
DR DrugBank; DB00224; Indinavir.
DR DrugBank; DB00328; Indomethacin.
DR DrugBank; DB11886; Infigratinib.
DR DrugBank; DB00762; Irinotecan.
DR DrugBank; DB11757; Istradefylline.
DR DrugBank; DB00602; Ivermectin.
DR DrugBank; DB01026; Ketoconazole.
DR DrugBank; DB09078; Lenvatinib.
DR DrugBank; DB12070; Letermovir.
DR DrugBank; DB08855; Leukotriene C4.
DR DrugBank; DB00583; Levocarnitine.
DR DrugBank; DB13153; Levomenol.
DR DrugBank; DB13139; Levosalbutamol.
DR DrugBank; DB00451; Levothyroxine.
DR DrugBank; DB00279; Liothyronine.
DR DrugBank; DB01583; Liotrix.
DR DrugBank; DB09198; Lobeglitazone.
DR DrugBank; DB06448; Lonafarnib.
DR DrugBank; DB01601; Lopinavir.
DR DrugBank; DB00227; Lovastatin.
DR DrugBank; DB12674; Lurbinectedin.
DR DrugBank; DB00563; Methotrexate.
DR DrugBank; DB00834; Mifepristone.
DR DrugBank; DB00688; Mycophenolate mofetil.
DR DrugBank; DB00220; Nelfinavir.
DR DrugBank; DB00622; Nicardipine.
DR DrugBank; DB01115; Nifedipine.
DR DrugBank; DB04868; Nilotinib.
DR DrugBank; DB01051; Novobiocin.
DR DrugBank; DB00646; Nystatin.
DR DrugBank; DB00275; Olmesartan.
DR DrugBank; DB11632; Opicapone.
DR DrugBank; DB11837; Osilodrostat.
DR DrugBank; DB01092; Ouabain.
DR DrugBank; DB15413; Pafolacianine.
DR DrugBank; DB09297; Paritaprevir.
DR DrugBank; DB06589; Pazopanib.
DR DrugBank; DB00859; Penicillamine.
DR DrugBank; DB12978; Pexidartinib.
DR DrugBank; DB13878; Pibrentasvir.
DR DrugBank; DB01132; Pioglitazone.
DR DrugBank; DB08860; Pitavastatin.
DR DrugBank; DB04850; Posizolid.
DR DrugBank; DB15822; Pralsetinib.
DR DrugBank; DB01708; Prasterone.
DR DrugBank; DB05804; Prasterone sulfate.
DR DrugBank; DB00175; Pravastatin.
DR DrugBank; DB00396; Progesterone.
DR DrugBank; DB04216; Quercetin.
DR DrugBank; DB00908; Quinidine.
DR DrugBank; DB00468; Quinine.
DR DrugBank; DB00481; Raloxifene.
DR DrugBank; DB14761; Remdesivir.
DR DrugBank; DB00912; Repaglinide.
DR DrugBank; DB00206; Reserpine.
DR DrugBank; DB11855; Revefenacin.
DR DrugBank; DB01045; Rifampicin.
DR DrugBank; DB11753; Rifamycin.
DR DrugBank; DB08864; Rilpivirine.
DR DrugBank; DB12457; Rimegepant.
DR DrugBank; DB00503; Ritonavir.
DR DrugBank; DB06176; Romidepsin.
DR DrugBank; DB00412; Rosiglitazone.
DR DrugBank; DB01098; Rosuvastatin.
DR DrugBank; DB12332; Rucaparib.
DR DrugBank; DB09292; Sacubitril.
DR DrugBank; DB01232; Saquinavir.
DR DrugBank; DB11362; Selexipag.
DR DrugBank; DB00203; Sildenafil.
DR DrugBank; DB09298; Silibinin.
DR DrugBank; DB06290; Simeprevir.
DR DrugBank; DB00641; Simvastatin.
DR DrugBank; DB00877; Sirolimus.
DR DrugBank; DB00398; Sorafenib.
DR DrugBank; DB00795; Sulfasalazine.
DR DrugBank; DB00669; Sumatriptan.
DR DrugBank; DB00864; Tacrolimus.
DR DrugBank; DB04348; Taurocholic acid.
DR DrugBank; DB09137; Technetium Tc-99m mebrofenin.
DR DrugBank; DB05521; Telaprevir.
DR DrugBank; DB00976; Telithromycin.
DR DrugBank; DB09299; Tenofovir alafenamide.
DR DrugBank; DB08880; Teriflunomide.
DR DrugBank; DB00932; Tipranavir.
DR DrugBank; DB06137; Tirbanibulin.
DR DrugBank; DB00214; Torasemide.
DR DrugBank; DB14962; Trastuzumab deruxtecan.
DR DrugBank; DB00197; Troglitazone.
DR DrugBank; DB15328; Ubrogepant.
DR DrugBank; DB15091; Upadacitinib.
DR DrugBank; DB00177; Valsartan.
DR DrugBank; DB11869; Valspodar.
DR DrugBank; DB11613; Velpatasvir.
DR DrugBank; DB11581; Venetoclax.
DR DrugBank; DB00661; Verapamil.
DR DrugBank; DB00570; Vinblastine.
DR DrugBank; DB00541; Vincristine.
DR DrugBank; DB12026; Voxilaprevir.
DR DrugCentral; Q9Y6L6; -.
DR GuidetoPHARMACOLOGY; 1220; -.
DR TCDB; 2.A.60.1.5; the organo anion transporter (oat) family.
DR GlyGen; Q9Y6L6; 6 sites.
DR iPTMnet; Q9Y6L6; -.
DR PhosphoSitePlus; Q9Y6L6; -.
DR BioMuta; SLCO1B1; -.
DR DMDM; 12643959; -.
DR EPD; Q9Y6L6; -.
DR MassIVE; Q9Y6L6; -.
DR PaxDb; Q9Y6L6; -.
DR PeptideAtlas; Q9Y6L6; -.
DR PRIDE; Q9Y6L6; -.
DR ProteomicsDB; 86719; -.
DR Antibodypedia; 23997; 182 antibodies from 27 providers.
DR DNASU; 10599; -.
DR Ensembl; ENST00000256958.3; ENSP00000256958.2; ENSG00000134538.3.
DR GeneID; 10599; -.
DR KEGG; hsa:10599; -.
DR MANE-Select; ENST00000256958.3; ENSP00000256958.2; NM_006446.5; NP_006437.3.
DR UCSC; uc001req.5; human.
DR CTD; 10599; -.
DR DisGeNET; 10599; -.
DR GeneCards; SLCO1B1; -.
DR GeneReviews; SLCO1B1; -.
DR HGNC; HGNC:10959; SLCO1B1.
DR HPA; ENSG00000134538; Tissue enriched (liver).
DR MalaCards; SLCO1B1; -.
DR MIM; 237450; phenotype.
DR MIM; 604843; gene.
DR neXtProt; NX_Q9Y6L6; -.
DR OpenTargets; ENSG00000134538; -.
DR Orphanet; 413696; Prediction of statin toxicity.
DR Orphanet; 3111; Rotor syndrome.
DR PharmGKB; PA134865839; -.
DR VEuPathDB; HostDB:ENSG00000134538; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244856; -.
DR HOGENOM; CLU_008954_4_0_1; -.
DR InParanoid; Q9Y6L6; -.
DR OMA; KKTRYCN; -.
DR OrthoDB; 1029129at2759; -.
DR PhylomeDB; Q9Y6L6; -.
DR TreeFam; TF317540; -.
DR PathwayCommons; Q9Y6L6; -.
DR Reactome; R-HSA-159418; Recycling of bile acids and salts.
DR Reactome; R-HSA-189483; Heme degradation.
DR Reactome; R-HSA-5619110; Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR).
DR Reactome; R-HSA-879518; Transport of organic anions.
DR Reactome; R-HSA-9754706; Atorvastatin ADME.
DR SABIO-RK; Q9Y6L6; -.
DR SignaLink; Q9Y6L6; -.
DR BioGRID-ORCS; 10599; 12 hits in 1059 CRISPR screens.
DR ChiTaRS; SLCO1B1; human.
DR GeneWiki; SLCO1B1; -.
DR GenomeRNAi; 10599; -.
DR Pharos; Q9Y6L6; Tchem.
DR PRO; PR:Q9Y6L6; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9Y6L6; protein.
DR Bgee; ENSG00000134538; Expressed in right lobe of liver and 28 other tissues.
DR ExpressionAtlas; Q9Y6L6; baseline and differential.
DR Genevisible; Q9Y6L6; HS.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0042167; P:heme catabolic process; TAS:Reactome.
DR GO; GO:0015711; P:organic anion transport; TAS:ProtInc.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..691
FT /note="Solute carrier organic anion transporter family
FT member 1B1"
FT /id="PRO_0000191050"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..197
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..255
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..353
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..373
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..397
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..401
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..425
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..537
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 538..560
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 561..569
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 570..595
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 596..629
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..647
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 648..691
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 453..508
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 672
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 682
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:23285087"
FT CARBOHYD 432
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 503
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:23285087"
FT CARBOHYD 516
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:23285087"
FT CARBOHYD 617
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 459..489
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 465..485
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 474..506
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VARIANT 73
FT /note="F -> L (in dbSNP:rs56101265)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015070"
FT VARIANT 82
FT /note="V -> A (in dbSNP:rs56061388)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015071"
FT VARIANT 130
FT /note="N -> D (in dbSNP:rs2306283)"
FT /evidence="ECO:0000269|PubMed:10601278,
FT ECO:0000269|PubMed:11477075, ECO:0000269|PubMed:12130747,
FT ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.6"
FT /id="VAR_015072"
FT VARIANT 151
FT /note="N -> S (in dbSNP:rs2306282)"
FT /id="VAR_057724"
FT VARIANT 152
FT /note="R -> K"
FT /evidence="ECO:0000269|PubMed:10358072,
FT ECO:0000269|PubMed:11477075, ECO:0000269|PubMed:12130747"
FT /id="VAR_015073"
FT VARIANT 155
FT /note="P -> T (decreased transport activity;
FT dbSNP:rs11045819)"
FT /evidence="ECO:0000269|PubMed:11477075,
FT ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:15489334"
FT /id="VAR_015074"
FT VARIANT 156
FT /note="E -> G (decreased transport activity;
FT dbSNP:rs72559745)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015075"
FT VARIANT 174
FT /note="V -> A (decreased transport activity;
FT dbSNP:rs4149056)"
FT /evidence="ECO:0000269|PubMed:11477075,
FT ECO:0000269|PubMed:12130747"
FT /id="VAR_015076"
FT VARIANT 193
FT /note="L -> R (strongly decreases expression at the plasma
FT membrane; abolishes transport activity; dbSNP:rs72559746)"
FT /evidence="ECO:0000269|PubMed:12196548"
FT /id="VAR_015077"
FT VARIANT 241
FT /note="D -> N (in dbSNP:rs751709893)"
FT /evidence="ECO:0000269|PubMed:10358072,
FT ECO:0000269|PubMed:11477075, ECO:0000269|PubMed:12130747"
FT /id="VAR_015078"
FT VARIANT 245
FT /note="I -> V (in dbSNP:rs11045852)"
FT /id="VAR_060108"
FT VARIANT 353
FT /note="I -> T (in dbSNP:rs55901008)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015079"
FT VARIANT 432
FT /note="N -> D (in dbSNP:rs56387224)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015080"
FT VARIANT 462
FT /note="D -> G (in dbSNP:rs72559748)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015081"
FT VARIANT 488
FT /note="G -> A (in dbSNP:rs59502379)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015082"
FT VARIANT 643
FT /note="L -> F (in dbSNP:rs34671512)"
FT /id="VAR_057725"
FT VARIANT 655
FT /note="D -> G (in dbSNP:rs56199088)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015083"
FT VARIANT 667
FT /note="E -> G (in dbSNP:rs55737008)"
FT /evidence="ECO:0000269|PubMed:11477075"
FT /id="VAR_015084"
SQ SEQUENCE 691 AA; 76449 MW; D13D5130189383A3 CRC64;
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS SIIHIERRFE
ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGGVL TALPHFFMGY
YRYSKETNIN SSENSTSTLS TCLINQILSL NRASPEIVGK GCLKESGSYM WIYVFMGNML
RGIGETPIVP LGLSYIDDFA KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV
DLSTIRITPT DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE
TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS SYIGAFTYVF
KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF KLNTVGIAKF SCFTAVMSLS
FYLLYFFILC ENKSVAGLTM TYDGNNPVTS HRDVPLSYCN SDCNCDESQW EPVCGNNGIT
YISPCLAGCK SSSGNKKPIV FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI
QVLNLFFSAL GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI
KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK YQEKDINASE
NGSVMDEANL ESLNKNKHFV PSAGADSETH C
