SO1B3_HUMAN
ID SO1B3_HUMAN Reviewed; 702 AA.
AC Q9NPD5; E7EMT8; Q5JAR4;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Solute carrier organic anion transporter family member 1B3;
DE AltName: Full=Liver-specific organic anion transporter 2;
DE Short=LST-2;
DE AltName: Full=Organic anion transporter 8;
DE AltName: Full=Organic anion-transporting polypeptide 8;
DE Short=OATP-8;
DE AltName: Full=Solute carrier family 21 member 8;
GN Name=SLCO1B3; Synonyms=LST2, OATP1B3, OATP8, SLC21A8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND GLYCOSYLATION.
RC TISSUE=Liver;
RX PubMed=10779507; DOI=10.1074/jbc.m001448200;
RA Koenig J., Cui Y., Nies A.T., Keppler D.;
RT "Localization and genomic organization of a new hepatocellular organic
RT anion transporting polypeptide.";
RL J. Biol. Chem. 275:23161-23168(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=11375950; DOI=10.1053/gast.2001.24804;
RA Abe T., Unno M., Onogawa T., Tokui T., Kondo T.N., Nakagomi R., Adachi H.,
RA Fujiwara K., Okabe M., Suzuki T., Nunoki K., Sato E., Kakyo M., Nishio T.,
RA Sugita J., Asano N., Tanemoto M., Seki M., Date F., Ono K., Kondo Y.,
RA Shiiba K., Suzuki M., Ohtani H., Shimosegawa T., Iinuma K., Nagura H.,
RA Ito S., Matsuno S.;
RT "LST-2, a human liver-specific organic anion transporter, determines
RT methotrexate sensitivity in gastrointestinal cancers.";
RL Gastroenterology 120:1689-1699(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Mizutamari H., Abe T.;
RT "Molecular identification of LST-3 subtype.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [5]
RP FUNCTION, AND INVOLVEMENT IN HBLRR.
RX PubMed=22232210; DOI=10.1172/jci59526;
RA van de Steeg E., Stranecky V., Hartmannova H., Noskova L., Hrebicek M.,
RA Wagenaar E., van Esch A., de Waart D.R., Oude Elferink R.P.,
RA Kenworthy K.E., Sticova E., al-Edreesi M., Knisely A.S., Kmoch S.,
RA Jirsa M., Schinkel A.H.;
RT "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by
RT interrupting conjugated bilirubin reuptake into the liver.";
RL J. Clin. Invest. 122:519-528(2012).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [7]
RP VARIANTS [LARGE SCALE ANALYSIS] MET-292 AND LEU-647.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Mediates the Na(+)-independent uptake of organic anions such
CC as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3),
CC leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate
CC and sulfobromophthalein (BSP). Involved in the clearance of bile acids
CC and organic anions from the liver. {ECO:0000269|PubMed:22232210}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane
CC protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NPD5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NPD5-2; Sequence=VSP_056615, VSP_056616, VSP_056617;
CC -!- TISSUE SPECIFICITY: Highly expressed in liver, in particular at the
CC basolateral membrane of hepatocytes near the central vein. Not detected
CC in other tissues. Highly expressed in some cancer cell lines derived
CC from colon, pancreas, liver and gall bladder.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:10779507}.
CC -!- DISEASE: Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An
CC autosomal recessive form of primary conjugated hyperbilirubinemia.
CC Affected individuals develop mild jaundice not associated with
CC hemolysis shortly after birth or in childhood. They have delayed plasma
CC clearance of the unconjugated anionic dye bromsulphthalein and
CC prominent urinary excretion of coproporphyrin I. Hepatic pigmentation
CC is normal. {ECO:0000269|PubMed:22232210}. Note=The disease is caused by
CC variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; AJ400763; CAB97008.1; -; Genomic_DNA.
DR EMBL; AJ400764; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400765; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400766; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400767; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400768; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400769; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400770; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400771; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400772; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400773; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400774; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400775; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ400776; CAB97008.1; JOINED; Genomic_DNA.
DR EMBL; AJ251506; CAB96997.1; -; mRNA.
DR EMBL; AF187815; AAG43445.1; -; mRNA.
DR EMBL; AY257471; AAP81212.1; -; mRNA.
DR EMBL; AY442326; AAS01768.1; -; mRNA.
DR EMBL; AC011604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC087309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS8684.1; -. [Q9NPD5-1]
DR RefSeq; NP_062818.1; NM_019844.3. [Q9NPD5-1]
DR AlphaFoldDB; Q9NPD5; -.
DR SMR; Q9NPD5; -.
DR BioGRID; 118182; 9.
DR STRING; 9606.ENSP00000261196; -.
DR BindingDB; Q9NPD5; -.
DR ChEMBL; CHEMBL1743121; -.
DR DrugBank; DB06403; Ambrisentan.
DR DrugBank; DB12597; Asciminib.
DR DrugBank; DB11586; Asunaprevir.
DR DrugBank; DB05016; Ataluren.
DR DrugBank; DB01072; Atazanavir.
DR DrugBank; DB16098; Atogepant.
DR DrugBank; DB01076; Atorvastatin.
DR DrugBank; DB11817; Baricitinib.
DR DrugBank; DB00394; Beclomethasone dipropionate.
DR DrugBank; DB15719; Belantamab mafodotin.
DR DrugBank; DB15463; Belzutifan.
DR DrugBank; DB11936; Bempedoic acid.
DR DrugBank; DB00188; Bortezomib.
DR DrugBank; DB12151; Brincidofovir.
DR DrugBank; DB06772; Cabazitaxel.
DR DrugBank; DB00520; Caspofungin.
DR DrugBank; DB08862; Cholecystokinin.
DR DrugBank; DB02659; Cholic Acid.
DR DrugBank; DB01211; Clarithromycin.
DR DrugBank; DB00257; Clotrimazole.
DR DrugBank; DB09065; Cobicistat.
DR DrugBank; DB05239; Cobimetinib.
DR DrugBank; DB00286; Conjugated estrogens.
DR DrugBank; DB00091; Cyclosporine.
DR DrugBank; DB08912; Dabrafenib.
DR DrugBank; DB09102; Daclatasvir.
DR DrugBank; DB12941; Darolutamide.
DR DrugBank; DB08995; Diosmin.
DR DrugBank; DB00975; Dipyridamole.
DR DrugBank; DB01248; Docetaxel.
DR DrugBank; DB05928; Dovitinib.
DR DrugBank; DB08861; DPDPE.
DR DrugBank; DB04855; Dronedarone.
DR DrugBank; DB15444; Elexacaftor.
DR DrugBank; DB09038; Empagliflozin.
DR DrugBank; DB13874; Enasidenib.
DR DrugBank; DB00199; Erythromycin.
DR DrugBank; DB00783; Estradiol.
DR DrugBank; DB13952; Estradiol acetate.
DR DrugBank; DB13953; Estradiol benzoate.
DR DrugBank; DB13954; Estradiol cypionate.
DR DrugBank; DB13955; Estradiol dienanthate.
DR DrugBank; DB13956; Estradiol valerate.
DR DrugBank; DB01590; Everolimus.
DR DrugBank; DB12500; Fedratinib.
DR DrugBank; DB12265; Fexinidazole.
DR DrugBank; DB00950; Fexofenadine.
DR DrugBank; DB01095; Fluvastatin.
DR DrugBank; DB11796; Fostemsavir.
DR DrugBank; DB08884; Gadoxetic acid.
DR DrugBank; DB01241; Gemfibrozil.
DR DrugBank; DB06749; Ginsenoside Rb1.
DR DrugBank; DB06750; Ginsenoside Rg1.
DR DrugBank; DB13879; Glecaprevir.
DR DrugBank; DB02691; Glycocholic acid.
DR DrugBank; DB11575; Grazoprevir.
DR DrugBank; DB12471; Ibrexafungerp.
DR DrugBank; DB09054; Idelalisib.
DR DrugBank; DB11886; Infigratinib.
DR DrugBank; DB11757; Istradefylline.
DR DrugBank; DB00602; Ivermectin.
DR DrugBank; DB09078; Lenvatinib.
DR DrugBank; DB12070; Letermovir.
DR DrugBank; DB08855; Leukotriene C4.
DR DrugBank; DB13153; Levomenol.
DR DrugBank; DB13139; Levosalbutamol.
DR DrugBank; DB00451; Levothyroxine.
DR DrugBank; DB00279; Liothyronine.
DR DrugBank; DB01583; Liotrix.
DR DrugBank; DB06448; Lonafarnib.
DR DrugBank; DB01601; Lopinavir.
DR DrugBank; DB00227; Lovastatin.
DR DrugBank; DB12674; Lurbinectedin.
DR DrugBank; DB00563; Methotrexate.
DR DrugBank; DB00834; Mifepristone.
DR DrugBank; DB00688; Mycophenolate mofetil.
DR DrugBank; DB01149; Nefazodone.
DR DrugBank; DB00220; Nelfinavir.
DR DrugBank; DB01051; Novobiocin.
DR DrugBank; DB00646; Nystatin.
DR DrugBank; DB00275; Olmesartan.
DR DrugBank; DB11632; Opicapone.
DR DrugBank; DB01092; Ouabain.
DR DrugBank; DB01229; Paclitaxel.
DR DrugBank; DB15413; Pafolacianine.
DR DrugBank; DB13154; Parachlorophenol.
DR DrugBank; DB09297; Paritaprevir.
DR DrugBank; DB12978; Pexidartinib.
DR DrugBank; DB13878; Pibrentasvir.
DR DrugBank; DB01132; Pioglitazone.
DR DrugBank; DB08860; Pitavastatin.
DR DrugBank; DB15822; Pralsetinib.
DR DrugBank; DB01708; Prasterone.
DR DrugBank; DB05804; Prasterone sulfate.
DR DrugBank; DB00175; Pravastatin.
DR DrugBank; DB00396; Progesterone.
DR DrugBank; DB00481; Raloxifene.
DR DrugBank; DB14761; Remdesivir.
DR DrugBank; DB11855; Revefenacin.
DR DrugBank; DB01045; Rifampicin.
DR DrugBank; DB11753; Rifamycin.
DR DrugBank; DB08864; Rilpivirine.
DR DrugBank; DB12457; Rimegepant.
DR DrugBank; DB00503; Ritonavir.
DR DrugBank; DB06176; Romidepsin.
DR DrugBank; DB01098; Rosuvastatin.
DR DrugBank; DB12332; Rucaparib.
DR DrugBank; DB09292; Sacubitril.
DR DrugBank; DB11362; Selexipag.
DR DrugBank; DB11942; Selinexor.
DR DrugBank; DB09298; Silibinin.
DR DrugBank; DB06290; Simeprevir.
DR DrugBank; DB00641; Simvastatin.
DR DrugBank; DB09142; Sincalide.
DR DrugBank; DB00795; Sulfasalazine.
DR DrugBank; DB04348; Taurocholic acid.
DR DrugBank; DB09137; Technetium Tc-99m mebrofenin.
DR DrugBank; DB00976; Telithromycin.
DR DrugBank; DB09299; Tenofovir alafenamide.
DR DrugBank; DB00624; Testosterone.
DR DrugBank; DB13946; Testosterone undecanoate.
DR DrugBank; DB00932; Tipranavir.
DR DrugBank; DB06137; Tirbanibulin.
DR DrugBank; DB14962; Trastuzumab deruxtecan.
DR DrugBank; DB15328; Ubrogepant.
DR DrugBank; DB00177; Valsartan.
DR DrugBank; DB11869; Valspodar.
DR DrugBank; DB11613; Velpatasvir.
DR DrugBank; DB00541; Vincristine.
DR DrugBank; DB12026; Voxilaprevir.
DR DrugCentral; Q9NPD5; -.
DR GuidetoPHARMACOLOGY; 1221; -.
DR TCDB; 2.A.60.1.12; the organo anion transporter (oat) family.
DR GlyGen; Q9NPD5; 8 sites, 1 N-linked glycan (2 sites).
DR iPTMnet; Q9NPD5; -.
DR PhosphoSitePlus; Q9NPD5; -.
DR BioMuta; SLCO1B3; -.
DR DMDM; 27734563; -.
DR MassIVE; Q9NPD5; -.
DR PaxDb; Q9NPD5; -.
DR PeptideAtlas; Q9NPD5; -.
DR PRIDE; Q9NPD5; -.
DR ProteomicsDB; 62988; -.
DR ProteomicsDB; 81974; -. [Q9NPD5-1]
DR Antibodypedia; 12268; 237 antibodies from 22 providers.
DR DNASU; 28234; -.
DR Ensembl; ENST00000261196.6; ENSP00000261196.2; ENSG00000111700.13. [Q9NPD5-1]
DR Ensembl; ENST00000381545.8; ENSP00000370956.4; ENSG00000111700.13. [Q9NPD5-1]
DR GeneID; 28234; -.
DR KEGG; hsa:28234; -.
DR MANE-Select; ENST00000381545.8; ENSP00000370956.4; NM_019844.4; NP_062818.1.
DR UCSC; uc001rel.5; human. [Q9NPD5-1]
DR CTD; 28234; -.
DR DisGeNET; 28234; -.
DR GeneCards; SLCO1B3; -.
DR GeneReviews; SLCO1B3; -.
DR HGNC; HGNC:10961; SLCO1B3.
DR HPA; ENSG00000111700; Tissue enriched (liver).
DR MalaCards; SLCO1B3; -.
DR MIM; 237450; phenotype.
DR MIM; 605495; gene.
DR neXtProt; NX_Q9NPD5; -.
DR OpenTargets; ENSG00000111700; -.
DR OpenTargets; ENSG00000257046; -.
DR Orphanet; 3111; Rotor syndrome.
DR PharmGKB; PA35844; -.
DR VEuPathDB; HostDB:ENSG00000111700; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244856; -.
DR HOGENOM; CLU_008954_4_0_1; -.
DR InParanoid; Q9NPD5; -.
DR OMA; VFHNCRC; -.
DR PhylomeDB; Q9NPD5; -.
DR TreeFam; TF317540; -.
DR PathwayCommons; Q9NPD5; -.
DR Reactome; R-HSA-159418; Recycling of bile acids and salts.
DR Reactome; R-HSA-189483; Heme degradation.
DR Reactome; R-HSA-5619058; Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR).
DR Reactome; R-HSA-879518; Transport of organic anions.
DR Reactome; R-HSA-9754706; Atorvastatin ADME.
DR BioGRID-ORCS; 28234; 8 hits in 1063 CRISPR screens.
DR ChiTaRS; SLCO1B3; human.
DR GeneWiki; SLCO1B3; -.
DR GenomeRNAi; 28234; -.
DR Pharos; Q9NPD5; Tchem.
DR PRO; PR:Q9NPD5; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NPD5; protein.
DR Bgee; ENSG00000111700; Expressed in right lobe of liver and 90 other tissues.
DR ExpressionAtlas; Q9NPD5; baseline and differential.
DR Genevisible; Q9NPD5; HS.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0042167; P:heme catabolic process; TAS:Reactome.
DR GO; GO:0015711; P:organic anion transport; TAS:ProtInc.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..702
FT /note="Solute carrier organic anion transporter family
FT member 1B3"
FT /id="PRO_0000191053"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..197
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..255
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..353
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..373
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..397
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..401
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..425
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..537
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 538..560
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 561..569
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 570..595
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 596..629
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..647
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 648..695
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 453..508
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6L6"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6L6"
FT MOD_RES 683
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6L6"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 445
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 503
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 516
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 459..489
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 465..485
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 474..506
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VAR_SEQ 622..664
FT /note="GRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERK -> GIVQP
FT ELKALAIGFHSMIMRSLGGILVPIYFGALIDTTCMKWSTNSCGARGACRIYNSTYLGRA
FT FFGLKVALIFPVLVLLTVFIFVVRKKSHGKDTKVLENERQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_056615"
FT VAR_SEQ 676..677
FT /note="NG -> DS (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_056616"
FT VAR_SEQ 685..702
FT /note="GTDSKTCNLDMQDNAAAN -> EEQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_056617"
FT VARIANT 112
FT /note="S -> A (in dbSNP:rs4149117)"
FT /id="VAR_024645"
FT VARIANT 233
FT /note="M -> I (in dbSNP:rs7311358)"
FT /id="VAR_053672"
FT VARIANT 256
FT /note="G -> A (in dbSNP:rs60140950)"
FT /id="VAR_062150"
FT VARIANT 292
FT /note="I -> M (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036410"
FT VARIANT 560
FT /note="V -> A (in dbSNP:rs12299012)"
FT /id="VAR_053673"
FT VARIANT 647
FT /note="M -> L (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs556554798)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036411"
SQ SEQUENCE 702 AA; 77403 MW; 6D2AE371D782C7FB CRC64;
MDQHQHLNKT AESASSEKKK TRRCNGFKMF LAALSFSYIA KALGGIIMKI SITQIERRFD
ISSSLAGLID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CLLMGTGSIL TSLPHFFMGY
YRYSKETHIN PSENSTSSLS TCLINQTLSF NGTSPEIVEK DCVKESGSHM WIYVFMGNML
RGIGETPIVP LGISYIDDFA KEGHSSLYLG SLNAIGMIGP VIGFALGSLF AKMYVDIGYV
DLSTIRITPK DSRWVGAWWL GFLVSGLFSI ISSIPFFFLP KNPNKPQKER KISLSLHVLK
TNDDRNQTAN LTNQGKNVTK NVTGFFQSLK SILTNPLYVI FLLLTLLQVS SFIGSFTYVF
KYMEQQYGQS ASHANFLLGI ITIPTVATGM FLGGFIIKKF KLSLVGIAKF SFLTSMISFL
FQLLYFPLIC ESKSVAGLTL TYDGNNSVAS HVDVPLSYCN SECNCDESQW EPVCGNNGIT
YLSPCLAGCK SSSGIKKHTV FYNCSCVEVT GLQNRNYSAH LGECPRDNTC TRKFFIYVAI
QVINSLFSAT GGTTFILLTV KIVQPELKAL AMGFQSMVIR TLGGILAPIY FGALIDKTCM
KWSTNSCGAQ GACRIYNSVF FGRVYLGLSI ALRFPALVLY IVFIFAMKKK FQGKDTKASD
NERKVMDEAN LEFLNNGEHF VPSAGTDSKT CNLDMQDNAA AN
