SO1B7_HUMAN
ID SO1B7_HUMAN Reviewed; 640 AA.
AC G3V0H7; Q71QF0;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Putative solute carrier organic anion transporter family member 1B7;
DE AltName: Full=Liver-specific organic anion transporter 3;
DE Short=LST-3;
GN Name=SLCO1B7; Synonyms=LST3, LST3TM12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Abe T.;
RT "LST-3, a novel liver-specific organic anion transporter.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
CC -!- CAUTION: Product of a dubious CDS prediction. May encode a non-
CC functional truncated protein. {ECO:0000305}.
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DR EMBL; AF401642; AAQ03085.1; -; mRNA.
DR EMBL; AC011604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC087309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471094; EAW96417.1; -; Genomic_DNA.
DR RefSeq; NP_001009562.3; NM_001009562.4.
DR AlphaFoldDB; G3V0H7; -.
DR SMR; G3V0H7; -.
DR STRING; 9606.ENSP00000394168; -.
DR TCDB; 2.A.60.1.29; the organo anion transporter (oat) family.
DR iPTMnet; G3V0H7; -.
DR PhosphoSitePlus; G3V0H7; -.
DR BioMuta; SLCO1B7; -.
DR MassIVE; G3V0H7; -.
DR PaxDb; G3V0H7; -.
DR PeptideAtlas; G3V0H7; -.
DR PRIDE; G3V0H7; -.
DR DNASU; 338821; -.
DR GeneID; 338821; -.
DR UCSC; uc010sin.2; human.
DR CTD; 338821; -.
DR DisGeNET; 338821; -.
DR GeneCards; SLCO1B7; -.
DR HGNC; HGNC:32934; SLCO1B7.
DR neXtProt; NX_G3V0H7; -.
DR eggNOG; KOG3626; Eukaryota.
DR HOGENOM; CLU_008954_4_0_1; -.
DR InParanoid; G3V0H7; -.
DR OrthoDB; 1029129at2759; -.
DR TreeFam; TF317540; -.
DR PathwayCommons; G3V0H7; -.
DR BioGRID-ORCS; 338821; 11 hits in 1055 CRISPR screens.
DR ChiTaRS; SLCO1B7; human.
DR GenomeRNAi; 338821; -.
DR Pharos; G3V0H7; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; G3V0H7; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..640
FT /note="Putative solute carrier organic anion transporter
FT family member 1B7"
FT /id="PRO_0000415774"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..329
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..362
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 384..492
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 514..521
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 543..577
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 578..598
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 599..640
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 406..461
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT MOD_RES 246
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6L6"
FT MOD_RES 636
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6L6"
FT DISULFID 412..442
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 418..438
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 427..459
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT CONFLICT 167
FT /note="V -> A (in Ref. 1; AAQ03085)"
FT /evidence="ECO:0000305"
FT CONFLICT 338
FT /note="A -> T (in Ref. 1; AAQ03085)"
FT /evidence="ECO:0000305"
FT CONFLICT 406
FT /note="D -> G (in Ref. 1; AAQ03085)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 640 AA; 71247 MW; AF0AD2AF6305AD66 CRC64;
MKISTTQIER RFEISSSLVG LIDGSFEIGN LFVIVFVSYF GSKLHRPKLI GIGCFLMGTG
SILMALPHFF MGYYRYSKET NIDPSENSTS NLPNCLINQM LSLNRTPSEI IERGCVKESG
SHMWIYVFMG NMLRGIGETP IVPLGISYID DFAKEGHSSL YLGTVNVMGM TGLVFAFMLG
SLFAKMYVDI GYVDLSTIRI TPKDSRWVGA WWLGFLVSGI VSIISSIPFF FLPLNPNKPQ
KERKVSLFLH VLKTNDKRNQ IANLTNRRKY ITKNVTGFFQ SLKSILTNPL YVIFVIFTLL
HMSSYIASLT YIIKMVEQQY GWSASKTNFL LGVLALPAVA IGMFSGGYII KKFKLSLVGL
AKLAFCSATV HLLSQVLYFF LICESKSVAG LTLTYDGNSP VRSHVDVPLS YCNSECNCDE
SQWEPVCGNN GITYLSPCLA GCKSSSGNKE PIVFYNCSCV EVIGLQNKNY SAHLGECPRD
DACTRKSYVY FVIQVLDAFL CAVGLTSYSV LVIRIVQPEL KALAIGFHSM IMRSLGGILV
PIYFGALIDT TCMKWSTNSC GARGACRIYN STYLGRAFFG LKVALIFPVL VLLTVFIFVV
RKKSHGKDTK VLENERQVMD EANLEFLNDS EHFVPSAEEQ
