SO2B1_HUMAN
ID SO2B1_HUMAN Reviewed; 709 AA.
AC O94956; A8K2G9; B4DGA9; B4DTB0; E7ERN5; E9PPU8; Q9H2Z0; Q9UFU1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Solute carrier organic anion transporter family member 2B1;
DE AltName: Full=Organic anion transporter B;
DE Short=OATP-B;
DE AltName: Full=Organic anion transporter polypeptide-related protein 2;
DE Short=OATP-RP2;
DE Short=OATPRP2;
DE AltName: Full=Solute carrier family 21 member 9;
GN Name=SLCO2B1; Synonyms=KIAA0880, OATP2B1, OATPB, SLC21A9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-392.
RC TISSUE=Brain;
RX PubMed=10873595; DOI=10.1006/bbrc.2000.2922;
RA Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A.;
RT "Molecular identification and characterization of novel members of the
RT human organic anion transporter (OATP) family.";
RL Biochem. Biophys. Res. Commun. 273:251-260(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND VARIANT THR-392.
RA Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.;
RT "Identification and characterization of novel human OATP family members.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-392.
RC TISSUE=Brain;
RX PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:355-364(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), AND VARIANTS
RP THR-392 AND PHE-486.
RC TISSUE=Amygdala, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-392.
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-392.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PRESENCE OF DISULFIDE BONDS.
RX PubMed=16754786; DOI=10.1124/mol.105.019547;
RA Hanggi E., Grundschober A.F., Leuthold S., Meier P.J., St-Pierre M.V.;
RT "Functional analysis of the extracellular cysteine residues in the human
RT organic anion transporting polypeptide, OATP2B1.";
RL Mol. Pharmacol. 70:806-817(2006).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP ALTERNATIVE PROMOTER USAGE, AND TISSUE SPECIFICITY.
RX PubMed=23531488; DOI=10.1124/mol.112.083618;
RA Knauer M.J., Girdwood A.J., Kim R.B., Tirona R.G.;
RT "Transport function and transcriptional regulation of a liver-enriched
RT human organic anion transporting polypeptide 2B1 transcriptional start site
RT variant.";
RL Mol. Pharmacol. 83:1218-1228(2013).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-318 AND SER-320, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [12]
RP VARIANT [LARGE SCALE ANALYSIS] LYS-77.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene
CC C4, thromboxane B2 and iloprost. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=1b, FL;
CC IsoId=O94956-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O94956-2; Sequence=VSP_006147, VSP_006148;
CC Name=3; Synonyms=1e, Short;
CC IsoId=O94956-3; Sequence=VSP_054109;
CC Name=4;
CC IsoId=O94956-4; Sequence=VSP_054110;
CC -!- TISSUE SPECIFICITY: Isoform 1 has it's highest expression in brain, it
CC is the major form expressed in duodenum, kidney, placenta, and skeletal
CC muscle. Isoform 3 predominates in liver. {ECO:0000269|PubMed:23531488}.
CC -!- MISCELLANEOUS: [Isoform 3]: Functional transporter. Predominant isoform
CC in liver, expression at promoter is regulated by HNF4alpha.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA74903.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB026256; BAA78638.1; -; mRNA.
DR EMBL; AF205073; AAG42205.1; -; mRNA.
DR EMBL; AB020687; BAA74903.2; ALT_INIT; mRNA.
DR EMBL; AK290234; BAF82923.1; -; mRNA.
DR EMBL; AK294503; BAG57720.1; -; mRNA.
DR EMBL; AK300134; BAG61922.1; -; mRNA.
DR EMBL; AL117465; CAB55940.1; -; mRNA.
DR EMBL; AP001972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC041095; AAH41095.1; -; mRNA.
DR CCDS; CCDS44683.1; -. [O94956-3]
DR CCDS; CCDS53679.1; -. [O94956-4]
DR CCDS; CCDS8235.1; -. [O94956-1]
DR PIR; T17250; T17250.
DR RefSeq; NP_001138683.1; NM_001145211.2.
DR RefSeq; NP_001138684.1; NM_001145212.2.
DR RefSeq; NP_009187.1; NM_007256.4.
DR AlphaFoldDB; O94956; -.
DR SMR; O94956; -.
DR BioGRID; 116442; 2.
DR IntAct; O94956; 2.
DR STRING; 9606.ENSP00000289575; -.
DR BindingDB; O94956; -.
DR ChEMBL; CHEMBL1743124; -.
DR DrugBank; DB03166; Acetic acid.
DR DrugBank; DB00770; Alprostadil.
DR DrugBank; DB11586; Asunaprevir.
DR DrugBank; DB01072; Atazanavir.
DR DrugBank; DB01076; Atorvastatin.
DR DrugBank; DB12319; Benzbromarone.
DR DrugBank; DB03793; Benzoic acid.
DR DrugBank; DB01053; Benzylpenicillin.
DR DrugBank; DB11591; Bilastine.
DR DrugBank; DB08862; Cholecystokinin.
DR DrugBank; DB04272; Citric acid.
DR DrugBank; DB00286; Conjugated estrogens.
DR DrugBank; DB09213; Dexibuprofen.
DR DrugBank; DB00255; Diethylstilbestrol.
DR DrugBank; DB00917; Dinoprostone.
DR DrugBank; DB08995; Diosmin.
DR DrugBank; DB00975; Dipyridamole.
DR DrugBank; DB05928; Dovitinib.
DR DrugBank; DB00530; Erlotinib.
DR DrugBank; DB13952; Estradiol acetate.
DR DrugBank; DB13953; Estradiol benzoate.
DR DrugBank; DB13954; Estradiol cypionate.
DR DrugBank; DB13955; Estradiol dienanthate.
DR DrugBank; DB13956; Estradiol valerate.
DR DrugBank; DB00655; Estrone.
DR DrugBank; DB00950; Fexofenadine.
DR DrugBank; DB01095; Fluvastatin.
DR DrugBank; DB01241; Gemfibrozil.
DR DrugBank; DB01645; Genistein.
DR DrugBank; DB01016; Glyburide.
DR DrugBank; DB01050; Ibuprofen.
DR DrugBank; DB01088; Iloprost.
DR DrugBank; DB00224; Indinavir.
DR DrugBank; DB01167; Itraconazole.
DR DrugBank; DB04398; Lactic acid.
DR DrugBank; DB11660; Latanoprostene bunod.
DR DrugBank; DB00451; Levothyroxine.
DR DrugBank; DB11611; Lifitegrast.
DR DrugBank; DB00227; Lovastatin.
DR DrugBank; DB16226; Maralixibat.
DR DrugBank; DB00471; Montelukast.
DR DrugBank; DB03467; Naringenin.
DR DrugBank; DB01149; Nefazodone.
DR DrugBank; DB00220; Nelfinavir.
DR DrugBank; DB00627; Niacin.
DR DrugBank; DB01051; Novobiocin.
DR DrugBank; DB11632; Opicapone.
DR DrugBank; DB03902; Oxalic Acid.
DR DrugBank; DB12978; Pexidartinib.
DR DrugBank; DB02746; Phthalic Acid.
DR DrugBank; DB00554; Piroxicam.
DR DrugBank; DB08860; Pitavastatin.
DR DrugBank; DB01708; Prasterone.
DR DrugBank; DB05804; Prasterone sulfate.
DR DrugBank; DB00175; Pravastatin.
DR DrugBank; DB04216; Quercetin.
DR DrugBank; DB00206; Reserpine.
DR DrugBank; DB01045; Rifampicin.
DR DrugBank; DB11753; Rifamycin.
DR DrugBank; DB00503; Ritonavir.
DR DrugBank; DB01098; Rosuvastatin.
DR DrugBank; DB00936; Salicylic acid.
DR DrugBank; DB01232; Saquinavir.
DR DrugBank; DB09298; Silibinin.
DR DrugBank; DB06290; Simeprevir.
DR DrugBank; DB00641; Simvastatin.
DR DrugBank; DB00795; Sulfasalazine.
DR DrugBank; DB04348; Taurocholic acid.
DR DrugBank; DB05521; Telaprevir.
DR DrugBank; DB00759; Tetracycline.
DR DrugBank; DB00932; Tipranavir.
DR DrugBank; DB01124; Tolbutamide.
DR DrugBank; DB00313; Valproic acid.
DR DrugBank; DB11613; Velpatasvir.
DR DrugCentral; O94956; -.
DR GuidetoPHARMACOLOGY; 1224; -.
DR TCDB; 2.A.60.1.20; the organo anion transporter (oat) family.
DR GlyGen; O94956; 2 sites.
DR iPTMnet; O94956; -.
DR PhosphoSitePlus; O94956; -.
DR BioMuta; SLCO2B1; -.
DR jPOST; O94956; -.
DR MassIVE; O94956; -.
DR MaxQB; O94956; -.
DR PaxDb; O94956; -.
DR PeptideAtlas; O94956; -.
DR PRIDE; O94956; -.
DR ProteomicsDB; 17820; -.
DR ProteomicsDB; 22826; -.
DR ProteomicsDB; 50577; -. [O94956-1]
DR ProteomicsDB; 50578; -. [O94956-2]
DR Antibodypedia; 17309; 109 antibodies from 18 providers.
DR DNASU; 11309; -.
DR Ensembl; ENST00000428359.6; ENSP00000388912.2; ENSG00000137491.15.
DR Ensembl; ENST00000454962.6; ENSP00000389653.2; ENSG00000137491.15.
DR GeneID; 11309; -.
DR KEGG; hsa:11309; -.
DR UCSC; uc001owc.4; human. [O94956-1]
DR CTD; 11309; -.
DR DisGeNET; 11309; -.
DR GeneCards; SLCO2B1; -.
DR HGNC; HGNC:10962; SLCO2B1.
DR HPA; ENSG00000137491; Tissue enhanced (liver).
DR MIM; 604988; gene.
DR neXtProt; NX_O94956; -.
DR PharmGKB; PA35845; -.
DR VEuPathDB; HostDB:ENSG00000137491; -.
DR eggNOG; KOG3626; Eukaryota.
DR HOGENOM; CLU_008954_4_2_1; -.
DR InParanoid; O94956; -.
DR OrthoDB; 1029129at2759; -.
DR PhylomeDB; O94956; -.
DR TreeFam; TF317540; -.
DR PathwayCommons; O94956; -.
DR Reactome; R-HSA-189483; Heme degradation. [O94956-3]
DR Reactome; R-HSA-879518; Transport of organic anions.
DR Reactome; R-HSA-9749641; Aspirin ADME. [O94956-1]
DR Reactome; R-HSA-9754706; Atorvastatin ADME. [O94956-3]
DR BioGRID-ORCS; 11309; 8 hits in 1077 CRISPR screens.
DR ChiTaRS; SLCO2B1; human.
DR GeneWiki; SLCO2B1; -.
DR GenomeRNAi; 11309; -.
DR Pharos; O94956; Tchem.
DR PRO; PR:O94956; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O94956; protein.
DR Bgee; ENSG00000137491; Expressed in right lobe of liver and 170 other tissues.
DR ExpressionAtlas; O94956; baseline and differential.
DR Genevisible; O94956; HS.
DR GO; GO:0016324; C:apical plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0042167; P:heme catabolic process; TAS:Reactome.
DR GO; GO:0015711; P:organic anion transport; IDA:ARUK-UCL.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IDA:ARUK-UCL.
DR GO; GO:0150104; P:transport across blood-brain barrier; NAS:ARUK-UCL.
DR GO; GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Alternative splicing; Cell membrane;
KW Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..709
FT /note="Solute carrier organic anion transporter family
FT member 2B1"
FT /id="PRO_0000191061"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..69
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..215
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..298
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..388
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..408
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..432
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..436
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..460
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 461..564
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 565..587
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 588..596
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 597..622
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 623..655
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 656..673
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 674..709
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 483..543
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BXB6"
FT MOD_RES 318
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 320
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 538
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 489..520
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 495..516
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 504..541
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VAR_SEQ 1..116
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_006147"
FT VAR_SEQ 1..22
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT /id="VSP_054109"
FT VAR_SEQ 6..149
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054110"
FT VAR_SEQ 150..260
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_006148"
FT VARIANT 77
FT /note="E -> K (in a breast cancer sample; somatic mutation;
FT dbSNP:rs865987804)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036412"
FT VARIANT 201
FT /note="V -> M (in dbSNP:rs35199625)"
FT /id="VAR_053675"
FT VARIANT 312
FT /note="R -> Q (in dbSNP:rs12422149)"
FT /id="VAR_053676"
FT VARIANT 392
FT /note="I -> T (in dbSNP:rs1621378)"
FT /evidence="ECO:0000269|PubMed:10048485,
FT ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.2"
FT /id="VAR_053677"
FT VARIANT 486
FT /note="S -> F (in dbSNP:rs2306168)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_020294"
FT CONFLICT 94
FT /note="N -> D (in Ref. 4; BAF82923)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="D -> V (in Ref. 2; AAG42205)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 709 AA; 76711 MW; 652DB4B70B2D9A2D CRC64;
MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL FVLCHSLLQL
AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA LIVFVSYFGS RVHRPRMIGY
GAILVALAGL LMTLPHFISE PYRYDNTSPE DMPQDFKASL CLPTTSAPAS APSNGNCSSY
TETQHLSVVG IMFVAQTLLG VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL
AFGLGSLMLR LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE
MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN LTVIQFIKVF
PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM AIFLPKFLER QFSITASYAN LLIGCLSFPS
VIVGIVVGGV LVKRLHLGPV GCGALCLLGM LLCLFFSLPL FFIGCSSHQI AGITHQTSAH
PGLELSPSCM EACSCPLDGF NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS
CVVEGNPVLA GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG
IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR FIGLQFFFKT
GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP GKKPEDSRV
