SO2B1_MOUSE
ID SO2B1_MOUSE Reviewed; 683 AA.
AC Q8BXB6; Q8BLV8;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Solute carrier organic anion transporter family member 2B1;
DE AltName: Full=Solute carrier family 21 member 9;
GN Name=Slco2b1; Synonyms=Oatp2b1, Slc21a9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17208939; DOI=10.1074/mcp.m600218-mcp200;
RA Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
RT "Mitochondrial phosphoproteome revealed by an improved IMAC method and
RT MS/MS/MS.";
RL Mol. Cell. Proteomics 6:669-676(2007).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=18630941; DOI=10.1021/pr800223m;
RA Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
RT "Specific phosphopeptide enrichment with immobilized titanium ion affinity
RT chromatography adsorbent for phosphoproteome analysis.";
RL J. Proteome Res. 7:3957-3967(2008).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene
CC C4, thromboxane B2 and iloprost. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK041144; BAC30838.1; -; mRNA.
DR EMBL; AK048120; BAC33248.1; -; mRNA.
DR CCDS; CCDS21485.1; -.
DR RefSeq; NP_001239459.1; NM_001252530.1.
DR RefSeq; NP_001239460.1; NM_001252531.1.
DR RefSeq; NP_780525.1; NM_175316.3.
DR RefSeq; XP_011239942.1; XM_011241640.2.
DR RefSeq; XP_011239943.1; XM_011241641.2.
DR AlphaFoldDB; Q8BXB6; -.
DR SMR; Q8BXB6; -.
DR STRING; 10090.ENSMUSP00000032985; -.
DR GlyGen; Q8BXB6; 4 sites.
DR iPTMnet; Q8BXB6; -.
DR PhosphoSitePlus; Q8BXB6; -.
DR jPOST; Q8BXB6; -.
DR MaxQB; Q8BXB6; -.
DR PaxDb; Q8BXB6; -.
DR PRIDE; Q8BXB6; -.
DR ProteomicsDB; 261105; -.
DR Antibodypedia; 17309; 109 antibodies from 18 providers.
DR DNASU; 101488; -.
DR Ensembl; ENSMUST00000032985; ENSMUSP00000032985; ENSMUSG00000030737.
DR Ensembl; ENSMUST00000107086; ENSMUSP00000102701; ENSMUSG00000030737.
DR GeneID; 101488; -.
DR KEGG; mmu:101488; -.
DR UCSC; uc009ilw.2; mouse.
DR CTD; 11309; -.
DR MGI; MGI:1351872; Slco2b1.
DR VEuPathDB; HostDB:ENSMUSG00000030737; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244906; -.
DR HOGENOM; CLU_008954_4_1_1; -.
DR InParanoid; Q8BXB6; -.
DR OMA; FMLGSAM; -.
DR OrthoDB; 1029129at2759; -.
DR TreeFam; TF317540; -.
DR Reactome; R-MMU-189483; Heme degradation.
DR Reactome; R-MMU-879518; Transport of organic anions.
DR Reactome; R-MMU-9749641; Aspirin ADME.
DR Reactome; R-MMU-9754706; Atorvastatin ADME.
DR BioGRID-ORCS; 101488; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Slco2b1; mouse.
DR PRO; PR:Q8BXB6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BXB6; protein.
DR Bgee; ENSMUSG00000030737; Expressed in brain blood vessel and 187 other tissues.
DR ExpressionAtlas; Q8BXB6; baseline and differential.
DR Genevisible; Q8BXB6; MM.
DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR GO; GO:0009925; C:basal plasma membrane; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; ISO:MGI.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; ISO:MGI.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; ISO:MGI.
DR GO; GO:0015721; P:bile acid and bile salt transport; ISO:MGI.
DR GO; GO:0015711; P:organic anion transport; ISO:MGI.
DR GO; GO:0071718; P:sodium-independent icosanoid transport; ISO:MGI.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; ISO:MGI.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..683
FT /note="Solute carrier organic anion transporter family
FT member 2B1"
FT /id="PRO_0000191062"
FT TOPO_DOM 1..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..177
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..207
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..377
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..397
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..421
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..425
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..449
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..553
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 554..576
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 577..585
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 586..611
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 612..644
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 645..662
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 663..683
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 472..532
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17208939,
FT ECO:0007744|PubMed:18630941"
FT MOD_RES 312
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94956"
FT MOD_RES 315
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JHI3"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 527
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 534
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 478..509
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 484..505
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 493..530
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ SEQUENCE 683 AA; 74531 MW; 20D977BA1482688A CRC64;
MPDRSTKTTM GTEDMHERKV SVEPQDSHQD AQPRGMFHNI KFFVLCHSLL QLTQLMISGY
LKSSISTVEK RFGLSSQISG LLAAFNEVGN VSLILFVSYF GSRVHRPRMI GYGALLVATA
GLLMALPHFI SEPYRYDHSS SDNRSLDFEA SLCLPTTMAP ASALSNGSCS SHTETKHLTM
VGIMFAAQTL LGIGGVPIQP FGISYIDDFA HHSNSPLYIG ILFGITTMGP GLAYGLGSLM
LRLYVDIDRM PEGGINLTPK DPRWVGAWWL GFLISSGLVV LASSPYFFFP REMPKEKHEF
HFRRKVLASA ASTASKGEDL SSQHEPLKKQ AGLAQIAPDL TLVQFVKVFP RVLLRNLRHP
IFLLVVLSQV CTSSMVAGMA TFLPKFLERQ FSITASFANM LLGCLTIPLV IVGIMMGGVL
VKRLHLSPVQ CSALCLLGSL LCLLFSVPLF FIGCSTHQIA GITQDLGAQP GPSLFPGCSE
PCSCQSDDFN PVCDTSAYVE YTTPCHAGCT GRVVQEALGK SQVFYTNCSC VAGNGTVPAG
SCESACSRLV LPFIVLFSLG AGLASITHTP SFMLILRGVK KEDKTLAVGM QFMLLRVLAW
MPSPVIHGSA IDTTCVHWAL TCGRRAVCRY YDHDLLRNRF IGLQFFFKSG SLVCFTLVLA
ILRQQSREAS TRTTVKSSEL QQL
