ID   SO2B1_RAT               Reviewed;         682 AA.
AC   Q9JHI3;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Solute carrier organic anion transporter family member 2B1;
DE   AltName: Full=Organic anion transporter moatp1;
DE   AltName: Full=Solute carrier family 21 member 9;
GN   Name=Slco2b1; Synonyms=Oatp2b1, Slc21a9;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC   TISSUE=Brain;
RX   PubMed=10973807; DOI=10.1006/bbrc.2000.3377;
RA   Nishio T., Adachi H., Nakagomi R., Tokui T., Sato E., Tanemoto M.,
RA   Fujiwara K., Okabe M., Onogawa T., Suzuki T., Nakai D., Shiiba K.,
RA   Suzuki M., Ohtani H., Kondo Y., Unno M., Ito S., Iinuma K., Nunoki K.,
RA   Matsuno S., Abe T.;
RT   "Molecular identification of a rat novel organic anion transporter moat1,
RT   which transports prostaglandin D(2), leukotriene C(4), and taurocholate.";
RL   Biochem. Biophys. Res. Commun. 275:831-838(2000).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-314, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC       such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene
CC       C4, thromboxane B2 and iloprost.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC       {ECO:0000305}.
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DR   EMBL; AF169410; AAF89671.1; -; mRNA.
DR   EMBL; AF169409; AAF89670.1; -; mRNA.
DR   PIR; JC7385; JC7385.
DR   RefSeq; NP_542964.1; NM_080786.1.
DR   RefSeq; XP_006229789.1; XM_006229727.3.
DR   RefSeq; XP_006229790.1; XM_006229728.3.
DR   AlphaFoldDB; Q9JHI3; -.
DR   SMR; Q9JHI3; -.
DR   STRING; 10116.ENSRNOP00000024281; -.
DR   BindingDB; Q9JHI3; -.
DR   ChEMBL; CHEMBL2073698; -.
DR   TCDB; 2.A.60.1.7; the organo anion transporter (oat) family.
DR   GlyGen; Q9JHI3; 4 sites.
DR   iPTMnet; Q9JHI3; -.
DR   PhosphoSitePlus; Q9JHI3; -.
DR   PaxDb; Q9JHI3; -.
DR   PRIDE; Q9JHI3; -.
DR   GeneID; 140860; -.
DR   KEGG; rno:140860; -.
DR   UCSC; RGD:621391; rat.
DR   CTD; 11309; -.
DR   RGD; 621391; Slco2b1.
DR   VEuPathDB; HostDB:ENSRNOG00000017976; -.
DR   eggNOG; KOG3626; Eukaryota.
DR   HOGENOM; CLU_008954_4_1_1; -.
DR   InParanoid; Q9JHI3; -.
DR   OMA; FMLGSAM; -.
DR   OrthoDB; 1029129at2759; -.
DR   PhylomeDB; Q9JHI3; -.
DR   Reactome; R-RNO-189483; Heme degradation.
DR   Reactome; R-RNO-879518; Transport of organic anions.
DR   Reactome; R-RNO-9749641; Aspirin ADME.
DR   Reactome; R-RNO-9754706; Atorvastatin ADME.
DR   PRO; PR:Q9JHI3; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000017976; Expressed in liver and 19 other tissues.
DR   ExpressionAtlas; Q9JHI3; baseline and differential.
DR   Genevisible; Q9JHI3; RN.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:ARUK-UCL.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0015125; F:bile acid transmembrane transporter activity; IDA:RGD.
DR   GO; GO:0008514; F:organic anion transmembrane transporter activity; ISO:RGD.
DR   GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IDA:RGD.
DR   GO; GO:0015721; P:bile acid and bile salt transport; IDA:RGD.
DR   GO; GO:0001889; P:liver development; IEP:RGD.
DR   GO; GO:0015711; P:organic anion transport; ISO:RGD.
DR   GO; GO:0071718; P:sodium-independent icosanoid transport; IDA:RGD.
DR   GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; ISO:RGD.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004156; OATP.
DR   PANTHER; PTHR11388; PTHR11388; 1.
DR   Pfam; PF03137; OATP; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00805; oat; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..682
FT                   /note="Solute carrier organic anion transporter family
FT                   member 2B1"
FT                   /id="PRO_0000191063"
FT   TOPO_DOM        1..41
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..61
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        62..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..107
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..132
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..176
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..206
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..264
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..289
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..354
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..376
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        377..396
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..420
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        421..424
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..448
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        449..552
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        553..575
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        576..584
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        585..610
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        611..643
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        644..661
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        662..682
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          471..531
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         21
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BXB6"
FT   MOD_RES         311
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         314
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        255
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        526
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        533
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        477..508
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        483..504
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        492..529
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ   SEQUENCE   682 AA;  74215 MW;  7CA4BBEAE21DE8C2 CRC64;
     MPDRSTKATM GAEDIHERKV SMEPRDSHQD AQPRGMFQNI KFFVLCHSIL QLAQLMISGY
     LKSSISTVEK RFGLSSQTSG LLAAFNEVGN ISLILFVSYF GSRVHRPRMI GCGAILVAVA
     GLLMALPHFI SEPYRYDHSS PDRSQDFEAS LCLPTTMAPA SALSNDSCSS RTETKHLTMV
     GIMFTAQTLL GIGGVPIQPF GISYIDDFAH HSNSPLYLGI LFAITMMGPG LAYGLGSLML
     RLYVDIDRMP EGGINLTTKD PRWVGAWWLG FLISAGLVVL AASPYFFFPR EMPKEKYELH
     FRQKVLAGGA SIGSKGEELS SQHEPLKKQA GLPQIAPDLT VVQFIKVFPR VLLRTLRHPI
     FLLVVLSQVC TSSMVAGTAT FLPKFLERQF SITASFANLL LGCLTIPLAI VGIVVGGVLV
     KRLHLSPMQC SALCLLGSLL CLLLSLPLFF IGCSTHHIAG ITQDLGAQPG PSLFPGCSEP
     CSCQSDDFNP VCDTSAYVEY TTPCHAGCTG RVVQEALDKS QVFYTNCSCV AGNGTISAGS
     CESACSRLVL PFILLISLGA AVASITHTPS FMLILRGVKK EDKTLAVGMQ FMLLRVLAWM
     PSPVIHGSAI DTTCVHWALT CGRRAVCRYY DHDLLRNRFI GLQFFFKSGS LVCFALVLAI
     LRQQSREAST KATVKSSDLQ EL