SO3A1_BOVIN
ID SO3A1_BOVIN Reviewed; 710 AA.
AC Q8HYW2; A4FV49;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Solute carrier organic anion transporter family member 3A1;
DE AltName: Full=Organic anion-transporting polypeptide D;
DE Short=OATP-D;
GN Name=SLCO3A1; Synonyms=OATP3A1, OATPD, SLC21A11;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RA Geyer J., Petzinger E.;
RT "Cloning of a new member of the OATP superfamily from bovine kidney (Oatp
RT 3a1).";
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Hereford; TISSUE=Hippocampus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions.
CC Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4),
CC deltorphin II, BQ-123 and vasopressin. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8HYW2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8HYW2-2; Sequence=VSP_036845, VSP_036846;
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; AJ508719; CAD48488.1; -; mRNA.
DR EMBL; BC123736; AAI23737.1; -; mRNA.
DR RefSeq; NP_001001134.1; NM_001001134.1. [Q8HYW2-1]
DR RefSeq; XP_005221768.1; XM_005221711.3. [Q8HYW2-2]
DR AlphaFoldDB; Q8HYW2; -.
DR SMR; Q8HYW2; -.
DR STRING; 9913.ENSBTAP00000002169; -.
DR PaxDb; Q8HYW2; -.
DR PRIDE; Q8HYW2; -.
DR Ensembl; ENSBTAT00000002169; ENSBTAP00000002169; ENSBTAG00000001652. [Q8HYW2-1]
DR Ensembl; ENSBTAT00000055950; ENSBTAP00000047887; ENSBTAG00000001652. [Q8HYW2-2]
DR GeneID; 407132; -.
DR KEGG; bta:407132; -.
DR CTD; 28232; -.
DR VEuPathDB; HostDB:ENSBTAG00000001652; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244856; -.
DR HOGENOM; CLU_008954_3_0_1; -.
DR InParanoid; Q8HYW2; -.
DR OMA; CNINCEC; -.
DR OrthoDB; 1029129at2759; -.
DR TreeFam; TF317540; -.
DR Reactome; R-BTA-879518; Transport of organic anions.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000001652; Expressed in cardiac ventricle and 107 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0015732; P:prostaglandin transport; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Cell membrane; Disulfide bond;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..710
FT /note="Solute carrier organic anion transporter family
FT member 3A1"
FT /id="PRO_0000369263"
FT TOPO_DOM 1..40
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..79
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..366
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 367..386
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..410
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 411..414
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..438
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 439..539
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 540..562
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 563..571
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..597
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 598..630
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..648
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 649..705
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 465..513
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9UIG8"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 457
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 502
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 519
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 471..501
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 477..497
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 486..511
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VAR_SEQ 667..692
FT /note="EFFASTLTLDNLGRDPVPANQTHRTK -> TEYQDIETEKTCPESQSPSEDS
FT FVRS (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_036845"
FT VAR_SEQ 693..710
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_036846"
SQ SEQUENCE 710 AA; 76555 MW; 1FE677A88523A21C CRC64;
MQAKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM LAQGTVGAYL
VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG ARGHRPRLIG CGGIVMALGA
LLSALPEFLT HQYKYEAGEI RWGAEGRDVC AANGSGGDQG PDPDLICRSR TATNMMYLLL
IGAQVLLGIG ATPVQPLGVS YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY
VDAVFIDTSN LDITPDDPRW IGAWWGGFLL CGALLFFSSV LMFGFPQSLP PHSDPALESE
QAMLPEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV FTCIILAACM
EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC LGIFLGGLLV KKLSLSALGA
IRMAMLVNLV STACYVSFLF LGCDTGPVAG VTVPYGNSST PGSALDPYSS CNKNCECQTD
SFTPVCGADG ITYLSACFAG CNSTNLTGCA CLMTIPPENA TVIPGKCPSP GCQEAFLTFL
CVMCVCSMIG AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
CLFWSTFCGE QGACALYDNV AYRYLYVSIA IALKSFAFLL YTTTWQCLRK NYKRYIKNHE
GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH EWCENMESVL
