SO4A1_HUMAN
ID SO4A1_HUMAN Reviewed; 722 AA.
AC Q96BD0; Q9H4T7; Q9H4T8; Q9H8P2; Q9NWX8; Q9UI35; Q9UIG7;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Solute carrier organic anion transporter family member 4A1;
DE Short=OATP4A1;
DE AltName: Full=Colon organic anion transporter;
DE AltName: Full=Organic anion transporter polypeptide-related protein 1;
DE Short=OATP-RP1;
DE Short=OATPRP1;
DE Short=POAT;
DE AltName: Full=Organic anion-transporting polypeptide E;
DE Short=OATP-E;
DE AltName: Full=Sodium-independent organic anion transporter E;
DE AltName: Full=Solute carrier family 21 member 12;
GN Name=SLCO4A1; Synonyms=OATP1, OATP4A1, OATPE, SLC21A12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=10873595; DOI=10.1006/bbrc.2000.2922;
RA Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A.;
RT "Molecular identification and characterization of novel members of the
RT human organic anion transporter (OATP) family.";
RL Biochem. Biophys. Res. Commun. 273:251-260(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus;
RX PubMed=11316767; DOI=10.1210/endo.142.5.8115;
RA Fujiwara K., Adachi H., Nishio T., Unno M., Tokui T., Okabe M., Onogawa T.,
RA Suzuki T., Asano N., Tanemoto M., Seki M., Shiiba K., Suzuki M., Kondo Y.,
RA Nunoki K., Shimosegawa T., Iinuma K., Ito S., Matsuno S., Abe T.;
RT "Identification of thyroid hormone transporters in humans: different
RT molecules are involved in a tissue-specific manner.";
RL Endocrinology 142:2005-2012(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM 3).
RA Itoh S., Coca-Prados M., Lu R., Chan B.S., Schuster V.L.;
RT "Molecular cloning of a putative organic anion transporter, POAT.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RA Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.;
RT "Identification and characterization of novel human OATP family members.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND VARIANT
RP ILE-78.
RC TISSUE=Ovarian carcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; THR-37; SER-40; SER-43;
RP SER-46 AND SER-50, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-43; SER-46 AND
RP SER-50, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-40 AND SER-43, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine)
CC and rT3, and of estrone-3-sulfate and taurocholate.
CC -!- INTERACTION:
CC Q96BD0; O00155: GPR25; NbExp=3; IntAct=EBI-2822217, EBI-10178951;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Comment=Experimental confirmation may be lacking for some isoforms.;
CC Name=1;
CC IsoId=Q96BD0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96BD0-2; Sequence=VSP_006152, VSP_006156;
CC Name=3;
CC IsoId=Q96BD0-3; Sequence=VSP_006153, VSP_006155;
CC Name=4;
CC IsoId=Q96BD0-4; Sequence=VSP_006154;
CC -!- TISSUE SPECIFICITY: Ubiquitous, with the exception of spleen and
CC leukocytes.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91247.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB031051; BAA89288.1; -; mRNA.
DR EMBL; AF187817; AAG43447.1; -; mRNA.
DR EMBL; AF104334; AAF15545.1; -; mRNA.
DR EMBL; AF205072; AAG42204.1; -; mRNA.
DR EMBL; AK023410; BAB14566.1; -; mRNA.
DR EMBL; AK000551; BAA91247.1; ALT_INIT; mRNA.
DR EMBL; AL357033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015727; AAH15727.1; -; mRNA.
DR CCDS; CCDS13501.1; -. [Q96BD0-1]
DR RefSeq; NP_057438.3; NM_016354.3. [Q96BD0-1]
DR AlphaFoldDB; Q96BD0; -.
DR SMR; Q96BD0; -.
DR BioGRID; 118180; 51.
DR IntAct; Q96BD0; 8.
DR MINT; Q96BD0; -.
DR STRING; 9606.ENSP00000217159; -.
DR ChEMBL; CHEMBL2073679; -.
DR DrugBank; DB01053; Benzylpenicillin.
DR DrugBank; DB00286; Conjugated estrogens.
DR DrugBank; DB00509; Dextrothyroxine.
DR DrugBank; DB00917; Dinoprostone.
DR DrugBank; DB13952; Estradiol acetate.
DR DrugBank; DB13953; Estradiol benzoate.
DR DrugBank; DB13954; Estradiol cypionate.
DR DrugBank; DB13955; Estradiol dienanthate.
DR DrugBank; DB13956; Estradiol valerate.
DR DrugBank; DB00451; Levothyroxine.
DR DrugBank; DB00279; Liothyronine.
DR DrugBank; DB01583; Liotrix.
DR DrugBank; DB04348; Taurocholic acid.
DR DrugBank; DB09100; Thyroid, porcine.
DR MEROPS; I01.972; -.
DR TCDB; 2.A.60.1.9; the organo anion transporter (oat) family.
DR GlyGen; Q96BD0; 2 sites.
DR iPTMnet; Q96BD0; -.
DR PhosphoSitePlus; Q96BD0; -.
DR SwissPalm; Q96BD0; -.
DR BioMuta; SLCO4A1; -.
DR DMDM; 27734555; -.
DR EPD; Q96BD0; -.
DR jPOST; Q96BD0; -.
DR MassIVE; Q96BD0; -.
DR MaxQB; Q96BD0; -.
DR PaxDb; Q96BD0; -.
DR PeptideAtlas; Q96BD0; -.
DR PRIDE; Q96BD0; -.
DR ProteomicsDB; 76061; -. [Q96BD0-1]
DR ProteomicsDB; 76062; -. [Q96BD0-2]
DR ProteomicsDB; 76063; -. [Q96BD0-3]
DR ProteomicsDB; 76064; -. [Q96BD0-4]
DR Antibodypedia; 29551; 37 antibodies from 15 providers.
DR DNASU; 28231; -.
DR Ensembl; ENST00000217159.6; ENSP00000217159.1; ENSG00000101187.16. [Q96BD0-1]
DR Ensembl; ENST00000370507.5; ENSP00000359538.1; ENSG00000101187.16. [Q96BD0-1]
DR GeneID; 28231; -.
DR KEGG; hsa:28231; -.
DR MANE-Select; ENST00000217159.6; ENSP00000217159.1; NM_016354.4; NP_057438.3.
DR UCSC; uc002ydb.1; human. [Q96BD0-1]
DR CTD; 28231; -.
DR DisGeNET; 28231; -.
DR GeneCards; SLCO4A1; -.
DR HGNC; HGNC:10953; SLCO4A1.
DR HPA; ENSG00000101187; Tissue enhanced (lung).
DR MIM; 612436; gene.
DR neXtProt; NX_Q96BD0; -.
DR OpenTargets; ENSG00000101187; -.
DR PharmGKB; PA35838; -.
DR VEuPathDB; HostDB:ENSG00000101187; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244906; -.
DR HOGENOM; CLU_008954_2_0_1; -.
DR InParanoid; Q96BD0; -.
DR OMA; IYTDWMT; -.
DR PhylomeDB; Q96BD0; -.
DR TreeFam; TF317540; -.
DR PathwayCommons; Q96BD0; -.
DR Reactome; R-HSA-879518; Transport of organic anions.
DR SignaLink; Q96BD0; -.
DR BioGRID-ORCS; 28231; 15 hits in 1075 CRISPR screens.
DR ChiTaRS; SLCO4A1; human.
DR GeneWiki; SLCO4A1; -.
DR GenomeRNAi; 28231; -.
DR Pharos; Q96BD0; Tbio.
DR PRO; PR:Q96BD0; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q96BD0; protein.
DR Bgee; ENSG00000101187; Expressed in metanephros cortex and 167 other tissues.
DR ExpressionAtlas; Q96BD0; baseline and differential.
DR Genevisible; Q96BD0; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR CDD; cd17462; MFS_SLCO4A_OATP4A; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR InterPro; IPR046329; SO4A1-like.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..722
FT /note="Solute carrier organic anion transporter family
FT member 4A1"
FT /id="PRO_0000191067"
FT TOPO_DOM 1..103
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..195
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..253
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..332
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..378
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..400
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..420
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..444
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 445..448
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..471
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 472..580
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 581..603
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 604..612
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 613..638
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 639..671
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 672..689
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 690..722
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 498..555
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 37
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 46
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT CARBOHYD 499
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 557
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 504..534
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 510..530
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 519..553
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VAR_SEQ 250..410
FT /note="TYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTT
FT ESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEA
FT SNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFL -> LFFAI
FT ACFLYKPLS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_006152"
FT VAR_SEQ 548..661
FT /note="YRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPAL
FT TATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVY
FT QNS -> SGAAAYRPCPPLDPGKGPPCLPLVIGAIVGLPRCTETVAVSLRIFPLVLAMH
FT CREMHFNLSEKAPPSGFHIRCNFLYIPQQHSCTNGNSTVSWGRVCACPELSLQHPEAEL
FT CRS (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_006153"
FT VAR_SEQ 572..603
FT /note="STCQRKPLLLVFIFVVIFFTFLSSIPALTATL -> TTALCAARTASCTSHC
FT ATQGALQPRRRMWTAR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_006154"
FT VAR_SEQ 662..722
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_006155"
FT VAR_SEQ 686..722
FT /note="CFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV -> SSRAASDHRPR
FT PPGHGGHSAFPDDRTVPLGDAITRELLFDLQPST (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_006156"
FT VARIANT 70
FT /note="R -> Q (in dbSNP:rs34419428)"
FT /id="VAR_053678"
FT VARIANT 78
FT /note="V -> I (in dbSNP:rs1047099)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_053679"
FT CONFLICT 246
FT /note="T -> M (in Ref. 5; BAB14566)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 722 AA; 77193 MW; DD8F0C10E4BCD255 CRC64;
MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC
QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV
NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM
GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG
ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT
TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA
SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE
AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP
MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET
NVDGQKVYRD CSCIPQNLSS GFGHATAGKC TSTCQRKPLL LVFIFVVIFF TFLSSIPALT
ATLRCVRDPQ RSFALGIQWI VVRILGGIPG PIAFGWVIDK ACLLWQDQCG QQGSCLVYQN
SAMSRYILIM GLLYKVLGVL FFAIACFLYK PLSESSDGLE TCLPSQSSAP DSATDSQLQS
SV
