SO4A1_MOUSE
ID SO4A1_MOUSE Reviewed; 723 AA.
AC Q8K078; Q8BZT4;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Solute carrier organic anion transporter family member 4A1;
DE AltName: Full=Organic anion-transporting polypeptide E;
DE Short=OATP-E;
DE AltName: Full=Sodium-independent organic anion transporter E;
DE AltName: Full=Solute carrier family 21 member 12;
GN Name=Slco4a1; Synonyms=Oatp4a1, Oatpe, Slc21a12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Cecum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- FUNCTION: Mediates the Na(+)-independent transport of organic anions
CC such as the thyroid hormone T3 (triiodo-L-thyronine) and of
CC taurocholate. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K078-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K078-2; Sequence=VSP_006157, VSP_006158;
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH33602.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK033598; BAC28379.1; -; mRNA.
DR EMBL; BC030719; AAH30719.1; -; mRNA.
DR EMBL; BC030720; AAH30720.1; -; mRNA.
DR EMBL; BC033602; AAH33602.1; ALT_INIT; mRNA.
DR CCDS; CCDS17176.1; -. [Q8K078-1]
DR RefSeq; NP_683735.1; NM_148933.1. [Q8K078-1]
DR RefSeq; XP_006500610.1; XM_006500547.2.
DR AlphaFoldDB; Q8K078; -.
DR SMR; Q8K078; -.
DR IntAct; Q8K078; 2.
DR MINT; Q8K078; -.
DR STRING; 10090.ENSMUSP00000045023; -.
DR GlyGen; Q8K078; 2 sites.
DR iPTMnet; Q8K078; -.
DR PhosphoSitePlus; Q8K078; -.
DR SwissPalm; Q8K078; -.
DR EPD; Q8K078; -.
DR MaxQB; Q8K078; -.
DR PaxDb; Q8K078; -.
DR PeptideAtlas; Q8K078; -.
DR PRIDE; Q8K078; -.
DR ProteomicsDB; 261106; -. [Q8K078-1]
DR ProteomicsDB; 261107; -. [Q8K078-2]
DR Antibodypedia; 29551; 37 antibodies from 15 providers.
DR DNASU; 108115; -.
DR Ensembl; ENSMUST00000038225; ENSMUSP00000045023; ENSMUSG00000038963. [Q8K078-1]
DR Ensembl; ENSMUST00000038259; ENSMUSP00000046502; ENSMUSG00000038963. [Q8K078-1]
DR GeneID; 108115; -.
DR KEGG; mmu:108115; -.
DR UCSC; uc008ojc.2; mouse. [Q8K078-1]
DR CTD; 28231; -.
DR MGI; MGI:1351866; Slco4a1.
DR VEuPathDB; HostDB:ENSMUSG00000038963; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244906; -.
DR HOGENOM; CLU_008954_2_0_1; -.
DR InParanoid; Q8K078; -.
DR OMA; IYTDWMT; -.
DR OrthoDB; 228564at2759; -.
DR PhylomeDB; Q8K078; -.
DR TreeFam; TF317540; -.
DR Reactome; R-MMU-879518; Transport of organic anions.
DR BioGRID-ORCS; 108115; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Slco4a1; mouse.
DR PRO; PR:Q8K078; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8K078; protein.
DR Bgee; ENSMUSG00000038963; Expressed in placenta labyrinth and 147 other tissues.
DR Genevisible; Q8K078; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; ISO:MGI.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR GO; GO:0042403; P:thyroid hormone metabolic process; ISO:MGI.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..723
FT /note="Solute carrier organic anion transporter family
FT member 4A1"
FT /id="PRO_0000191068"
FT TOPO_DOM 1..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..194
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..224
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..255
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..334
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..380
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..402
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..422
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..446
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 447..450
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..473
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 474..582
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..605
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 606..614
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 615..640
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..673
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 674..691
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 692..723
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 500..557
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 23..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 39
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96BD0"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96BD0"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96BD0"
FT CARBOHYD 212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 566
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 506..536
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 521..555
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VAR_SEQ 629..632
FT /note="SIPG -> TAWG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_006157"
FT VAR_SEQ 633..723
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_006158"
FT CONFLICT 28
FT /note="S -> R (in Ref. 1; BAC28379)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 723 AA; 77669 MW; 0856B45F02C4EBAC CRC64;
MPQHAMGDTH FLSLPKHLFT STSSATDSGC DTPPSSRASP ASLRSAHGTL GSSSQPLFEP
QAEKRSSQTA REVQYVSSGP QNSLCGWQAF TPKCLQVFNT PKGFLFFLCA ASFLQGMTVN
GFINTVITSI ERRFDLHSYQ SGLIASSYDI AACLCLTFVS YFGGNGHKPR WLGWGVLVLG
IGSLVFALPH FTAGRYEVEM DEGLGTGTCL TNQSHVECKD SASGLSNYRL IFMLGQLLHG
VGATPLYTLG VTYLDENVKS SYSPIYIAIF YTAAILGPAA GYLIGGAMLN VYTEVGQRTE
LTTDSPLWVG AWWIGFLGTG IAAFLIAIPI LGYPRQLPGS QRYVVMRAAE TQQLKDHSRG
AVSNPAFGKT VRDLPLSIWL LLRNPTFILL CLAGATEATL IAGMSTFGPK FFEAQFSLSA
SEAATLFGYL VVPAGGGGTL LGGFLVNKFK LRGSGIIRFC LFCTLTSLLA FFVFLMHCPN
VHMAGVTTGY VGSLLPKGQL DLKAACNAIY CCQPKHYSPL CGSDGTMYYS PCYAGCPADA
ETDLGGQKVY RGCSCILEKA SSGWGNATAG KCASTCQSKP FLLVLVFVVI IFTFLSSIPA
LTATLRCVSD RQRSFALGIQ WIVVRTLGSI PGPIAFGWVI DKACLLWQDQ CGHQGSCFVY
ENEAMSRYML IAGLTFKVLG FLFFVAAYFL YKSPSVSSDG LEASLPSQSS ASDSPTEQLQ
SNV
