SO5A1_HUMAN
ID SO5A1_HUMAN Reviewed; 848 AA.
AC Q9H2Y9; A4QPC2; B2RPF7; B3KMU7; E9PKK5; G3V1C0;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Solute carrier organic anion transporter family member 5A1;
DE AltName: Full=Organic anion transporter polypeptide-related protein 4;
DE Short=OATP-RP4;
DE Short=OATPRP4;
DE AltName: Full=Solute carrier family 21 member 15;
GN Name=SLCO5A1; Synonyms=OATP5A1, SLC21A15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.;
RT "Identification and characterization of novel human OATP family members.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP PHE-33.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9H2Y9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H2Y9-2; Sequence=VSP_045498;
CC Name=3;
CC IsoId=Q9H2Y9-3; Sequence=VSP_045499, VSP_045500;
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; AF205075; AAG42207.1; -; mRNA.
DR EMBL; AK022760; BAG51109.1; -; mRNA.
DR EMBL; AC024680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC091047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471068; EAW86957.1; -; Genomic_DNA.
DR EMBL; CH471068; EAW86958.1; -; Genomic_DNA.
DR EMBL; BC137424; AAI37425.1; -; mRNA.
DR EMBL; BC139755; AAI39756.1; -; mRNA.
DR CCDS; CCDS55242.1; -. [Q9H2Y9-2]
DR CCDS; CCDS55243.1; -. [Q9H2Y9-3]
DR CCDS; CCDS6205.1; -. [Q9H2Y9-1]
DR RefSeq; NP_001139480.1; NM_001146008.1. [Q9H2Y9-3]
DR RefSeq; NP_001139481.1; NM_001146009.1. [Q9H2Y9-2]
DR RefSeq; NP_112220.2; NM_030958.2. [Q9H2Y9-1]
DR RefSeq; XP_005251370.1; XM_005251313.2. [Q9H2Y9-2]
DR RefSeq; XP_016869372.1; XM_017013883.1. [Q9H2Y9-3]
DR AlphaFoldDB; Q9H2Y9; -.
DR SMR; Q9H2Y9; -.
DR BioGRID; 123587; 2.
DR IntAct; Q9H2Y9; 2.
DR STRING; 9606.ENSP00000260126; -.
DR MEROPS; I01.972; -.
DR TCDB; 2.A.60.1.16; the organo anion transporter (oat) family.
DR GlyGen; Q9H2Y9; 7 sites.
DR iPTMnet; Q9H2Y9; -.
DR PhosphoSitePlus; Q9H2Y9; -.
DR BioMuta; SLCO5A1; -.
DR DMDM; 296452911; -.
DR MassIVE; Q9H2Y9; -.
DR PaxDb; Q9H2Y9; -.
DR PeptideAtlas; Q9H2Y9; -.
DR PRIDE; Q9H2Y9; -.
DR Antibodypedia; 12199; 34 antibodies from 16 providers.
DR DNASU; 81796; -.
DR Ensembl; ENST00000260126.9; ENSP00000260126.3; ENSG00000137571.11. [Q9H2Y9-1]
DR Ensembl; ENST00000524945.5; ENSP00000434422.1; ENSG00000137571.11. [Q9H2Y9-3]
DR Ensembl; ENST00000530307.1; ENSP00000431611.1; ENSG00000137571.11. [Q9H2Y9-2]
DR GeneID; 81796; -.
DR KEGG; hsa:81796; -.
DR MANE-Select; ENST00000260126.9; ENSP00000260126.3; NM_030958.3; NP_112220.2.
DR UCSC; uc003xyk.4; human. [Q9H2Y9-1]
DR CTD; 81796; -.
DR DisGeNET; 81796; -.
DR GeneCards; SLCO5A1; -.
DR HGNC; HGNC:19046; SLCO5A1.
DR HPA; ENSG00000137571; Tissue enhanced (lymphoid tissue, skeletal muscle, tongue).
DR MIM; 613543; gene.
DR neXtProt; NX_Q9H2Y9; -.
DR OpenTargets; ENSG00000137571; -.
DR PharmGKB; PA134948571; -.
DR VEuPathDB; HostDB:ENSG00000137571; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244906; -.
DR HOGENOM; CLU_008954_1_1_1; -.
DR InParanoid; Q9H2Y9; -.
DR OMA; GMNCLAQ; -.
DR PhylomeDB; Q9H2Y9; -.
DR TreeFam; TF317540; -.
DR PathwayCommons; Q9H2Y9; -.
DR SignaLink; Q9H2Y9; -.
DR BioGRID-ORCS; 81796; 9 hits in 1061 CRISPR screens.
DR ChiTaRS; SLCO5A1; human.
DR GenomeRNAi; 81796; -.
DR Pharos; Q9H2Y9; Tbio.
DR PRO; PR:Q9H2Y9; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9H2Y9; protein.
DR Bgee; ENSG00000137571; Expressed in skeletal muscle tissue of rectus abdominis and 108 other tissues.
DR ExpressionAtlas; Q9H2Y9; baseline and differential.
DR Genevisible; Q9H2Y9; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..848
FT /note="Solute carrier organic anion transporter family
FT member 5A1"
FT /id="PRO_0000191070"
FT TOPO_DOM 1..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..220
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..290
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..329
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..369
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 370..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..449
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..469
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..493
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 494..497
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 498..521
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 522..651
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 652..674
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 675..683
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 684..709
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 710..742
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 743..760
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 761..808
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 549..603
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 469
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 550
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 590
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 597
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 730
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 555..585
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 561..581
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 570..601
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VAR_SEQ 420..474
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045498"
FT VAR_SEQ 675..687
FT /note="RSVEDEERPFALG -> SIHSYSNLLWSSH (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045499"
FT VAR_SEQ 688..848
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045500"
FT VARIANT 33
FT /note="L -> F (in dbSNP:rs3750266)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_022041"
FT CONFLICT 40
FT /note="V -> A (in Ref. 2; BAG51109)"
FT /evidence="ECO:0000305"
FT CONFLICT 264
FT /note="V -> L (in Ref. 1; AAG42207)"
FT /evidence="ECO:0000305"
FT CONFLICT 457
FT /note="K -> E (in Ref. 2; BAG51109)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 848 AA; 91864 MW; F213B18FE8389596 CRC64;
MDEGTGLQPG AGEQLEAPAT AEAVQERCEP ETLRSKSLPV LSSASCRPSL SPTSGDANPA
FGCVDSSGHQ ELKQGPNPLA PSPSAPSTSA GLGDCNHRVD LSKTFSVSSA LAMLQERRCL
YVVLTDSRCF LVCMCFLTFI QALMVSGYLS SVITTIERRY SLKSSESGLL VSCFDIGNLV
VVVFVSYFGG RGRRPLWLAV GGLLIAFGAA LFALPHFISP PYQIQELNAS APNDGLCQGG
NSTATLEPPA CPKDSGGNNH WVYVALFICA QILIGMGSTP IYTLGPTYLD DNVKKENSSL
YLAIMYVMGA LGPAVGYLLG GLLIGFYVDP RNPVHLDQND PRFIGNWWSG FLLCAIAMFL
VIFPMFTFPK KLPPRHKKKK KKKFSVDAVS DDDVLKEKSN NSEQADKKVS SMGFGKDVRD
LPRAAVRILS NMTFLFVSLS YTAESAIVTA FITFIPKFIE SQFGIPASNA SIYTGVIIVP
SAGVGIVLGG YIIKKLKLGA RESAKLAMIC SGVSLLCFST LFIVGCESIN LGGINIPYTT
GPSLTMPHRN LTGSCNVNCG CKIHEYEPVC GSDGITYFNP CLAGCVNSGN LSTGIRNYTE
CTCVQSRQVI TPPTVGQRSQ LRVVIVKTYL NENGYAVSGK CKRTCNTLIP FLVFLFIVTF
ITACAQPSAI IVTLRSVEDE ERPFALGMQF VLLRTLAYIP TPIYFGAVID TTCMLWQQEC
GVQGSCWEYN VTSFRFVYFG LAAGLKFVGF IFIFLAWYSI KYKEDGLQRR RQREFPLSTV
SERVGHPDNA RTRSCPAFST QGEFHEETGL QKGIQCAAQT YPGPFPEAIS SSADPGLEES
PAALEPPS
