SO6A1_HUMAN
ID SO6A1_HUMAN Reviewed; 719 AA.
AC Q86UG4; A6NHC1; Q6ZMY5; Q86UV2; Q8IYU5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Solute carrier organic anion transporter family member 6A1;
DE AltName: Full=Cancer/testis antigen 48;
DE Short=CT48;
DE AltName: Full=Gonad-specific transporter;
DE Short=GST;
DE AltName: Full=Organic anion-transporting polypeptide 6A1;
DE AltName: Full=Organic anion-transporting polypeptide I;
DE Short=OATP-I;
DE AltName: Full=Solute carrier family 21 member 19;
GN Name=SLCO6A1; Synonyms=OATP6A1, SLC21A19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Fu-Zhang W.;
RT "Cloning and characterization of two novel OATP genes on human 5q21.1.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=12677006; DOI=10.1210/me.2002-0304;
RA Suzuki T., Onogawa T., Asano N., Mizutamari H., Mikkaichi T., Tanemoto M.,
RA Abe M., Satoh F., Unno M., Nunoki K., Suzuki M., Hishinuma T., Goto J.,
RA Shimosegawa T., Matsuno S., Ito S., Abe T.;
RT "Identification and characterization of novel rat and human gonad-specific
RT organic anion transporters.";
RL Mol. Endocrinol. 17:1203-1215(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT ARG-654.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP TISSUE SPECIFICITY, AND IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
RX PubMed=15546177;
RA Lee S.-Y., Williamson B., Caballero O.L., Chen Y.-T., Scanlan M.J.,
RA Ritter G., Jongeneel C.V., Simpson A.J.G., Old L.J.;
RT "Identification of the gonad-specific anion transporter SLCO6A1 as a
RT cancer/testis (CT) antigen expressed in human lung cancer.";
RL Cancer Immun. 4:13-13(2004).
CC -!- INTERACTION:
CC Q86UG4-2; O76024: WFS1; NbExp=3; IntAct=EBI-21657139, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q86UG4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86UG4-2; Sequence=VSP_028753;
CC Name=3;
CC IsoId=Q86UG4-3; Sequence=VSP_028753, VSP_028754;
CC -!- TISSUE SPECIFICITY: Strongly expressed in testis. Weakly expressed in
CC spleen, brain, fetal brain and placenta. Detected in lung tumors.
CC {ECO:0000269|PubMed:12677006, ECO:0000269|PubMed:15546177}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000305}.
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DR EMBL; AY273897; AAP33048.1; -; mRNA.
DR EMBL; AF505657; AAP30851.1; -; mRNA.
DR EMBL; AK131445; BAD18590.1; -; mRNA.
DR EMBL; AC094108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471086; EAW49095.1; -; Genomic_DNA.
DR EMBL; BC034976; AAH34976.1; -; mRNA.
DR CCDS; CCDS34206.1; -. [Q86UG4-1]
DR CCDS; CCDS75282.1; -. [Q86UG4-2]
DR CCDS; CCDS78042.1; -. [Q86UG4-3]
DR RefSeq; NP_001275931.1; NM_001289002.1. [Q86UG4-1]
DR RefSeq; NP_001275933.1; NM_001289004.1. [Q86UG4-2]
DR RefSeq; NP_001294943.1; NM_001308014.1.
DR RefSeq; NP_775759.3; NM_173488.4. [Q86UG4-1]
DR RefSeq; XP_005271931.1; XM_005271874.3. [Q86UG4-1]
DR AlphaFoldDB; Q86UG4; -.
DR SMR; Q86UG4; -.
DR BioGRID; 126359; 25.
DR IntAct; Q86UG4; 16.
DR STRING; 9606.ENSP00000421339; -.
DR TCDB; 2.A.60.1.17; the organo anion transporter (oat) family.
DR GlyGen; Q86UG4; 4 sites.
DR iPTMnet; Q86UG4; -.
DR PhosphoSitePlus; Q86UG4; -.
DR BioMuta; SLCO6A1; -.
DR DMDM; 160185610; -.
DR MassIVE; Q86UG4; -.
DR PaxDb; Q86UG4; -.
DR PeptideAtlas; Q86UG4; -.
DR PRIDE; Q86UG4; -.
DR ProteomicsDB; 69818; -. [Q86UG4-1]
DR ProteomicsDB; 69819; -. [Q86UG4-2]
DR ProteomicsDB; 69820; -. [Q86UG4-3]
DR Antibodypedia; 13335; 95 antibodies from 25 providers.
DR DNASU; 133482; -.
DR Ensembl; ENST00000379807.7; ENSP00000369135.3; ENSG00000205359.10. [Q86UG4-1]
DR Ensembl; ENST00000389019.7; ENSP00000373671.3; ENSG00000205359.10. [Q86UG4-2]
DR Ensembl; ENST00000506729.6; ENSP00000421339.1; ENSG00000205359.10. [Q86UG4-1]
DR GeneID; 133482; -.
DR KEGG; hsa:133482; -.
DR MANE-Select; ENST00000506729.6; ENSP00000421339.1; NM_173488.5; NP_775759.3.
DR UCSC; uc003knn.5; human. [Q86UG4-1]
DR CTD; 133482; -.
DR DisGeNET; 133482; -.
DR GeneCards; SLCO6A1; -.
DR HGNC; HGNC:23613; SLCO6A1.
DR HPA; ENSG00000205359; Tissue enriched (testis).
DR MIM; 613365; gene.
DR neXtProt; NX_Q86UG4; -.
DR OpenTargets; ENSG00000205359; -.
DR PharmGKB; PA134949852; -.
DR VEuPathDB; HostDB:ENSG00000205359; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01050000244906; -.
DR HOGENOM; CLU_008954_2_1_1; -.
DR InParanoid; Q86UG4; -.
DR OMA; LMRFVIV; -.
DR PhylomeDB; Q86UG4; -.
DR TreeFam; TF317540; -.
DR PathwayCommons; Q86UG4; -.
DR SignaLink; Q86UG4; -.
DR BioGRID-ORCS; 133482; 10 hits in 1061 CRISPR screens.
DR ChiTaRS; SLCO6A1; human.
DR GenomeRNAi; 133482; -.
DR Pharos; Q86UG4; Tbio.
DR PRO; PR:Q86UG4; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q86UG4; protein.
DR Bgee; ENSG00000205359; Expressed in sperm and 60 other tissues.
DR ExpressionAtlas; Q86UG4; baseline and differential.
DR Genevisible; Q86UG4; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; PTHR11388; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00805; oat; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..719
FT /note="Solute carrier organic anion transporter family
FT member 6A1"
FT /id="PRO_0000307642"
FT TOPO_DOM 1..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..126
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..145
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..196
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..254
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..311
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..336
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..378
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..400
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..420
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..444
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 445..448
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..472
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 473..581
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 582..604
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 605..613
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 614..639
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 640..673
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 674..691
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 692..719
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 496..551
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 497
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 661
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 502..532
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 508..528
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 517..549
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT VAR_SEQ 206..267
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_028753"
FT VAR_SEQ 301..491
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028754"
FT VARIANT 27
FT /note="A -> V (in dbSNP:rs13190449)"
FT /id="VAR_036622"
FT VARIANT 381
FT /note="K -> R (in dbSNP:rs17150488)"
FT /id="VAR_036623"
FT VARIANT 527
FT /note="P -> A (in dbSNP:rs10073333)"
FT /id="VAR_053680"
FT VARIANT 654
FT /note="T -> R (in dbSNP:rs10055840)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_036624"
FT CONFLICT 23
FT /note="E -> D (in Ref. 3; BAD18590)"
FT /evidence="ECO:0000305"
FT CONFLICT 77..79
FT /note="KPG -> NRE (in Ref. 1; AAP33048)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="N -> K (in Ref. 3; BAD18590)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 719 AA; 79232 MW; 56EFD346A8F0569B CRC64;
MFVGVARHSG SQDEVSRGVE PLEAARAQPA KDRRAKGTPK SSKPGKKHRY LRLLPEALIR
FGGFRKRKKA KSSVSKKPGE VDDSLEQPCG LGCLVSTCCE CCNNIRCFMI FYCILLICQG
VVFGLIDVSI GDFQKEYQLK TIEKLALEKS YDISSGLVAI FIAFYGDRKK VIWFVASSFL
IGLGSLLCAF PSINEENKQS KVGIEDICEE IKVVSGCQSS GISFQSKYLS FFILGQTVQG
IAGMPLYILG ITFIDENVAT HSAGIYLGIA ECTSMIGYAL GYVLGAPLVK VPENTTSATN
TTVNNGSPEW LWTWWINFLF AAVVAWCTLI PLSCFPNNMP GSTRIKARKR KQLHFFDSRL
KDLKLGTNIK DLCAALWILM KNPVLICLAL SKATEYLVII GASEFLPIYL ENQFILTPTV
ATTLAGLVLI PGGALGQLLG GVIVSTLEMS CKALMRFIMV TSVISLILLV FIIFVRCNPV
QFAGINEDYD GTGKLGNLTA PCNEKCRCSS SIYSSICGRD DIEYFSPCFA GCTYSKAQNQ
KKMYYNCSCI KEGLITADAE GDFIDARPGK CDAKCYKLPL FIAFIFSTLI FSGFSGVPIV
LAMTRVVPDK LRSLALGVSY VILRIFGTIP GPSIFKMSGE TSCILRDVNK CGHTGRCWIY
NKTKMAFLLV GICFLCKLCT IIFTTIAFFI YKRRLNENTD FPDVTVKNPK VKKKEETDL
