SOAT_HUMAN
ID SOAT_HUMAN Reviewed; 377 AA.
AC Q3KNW5; Q70EX7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Sodium-dependent organic anion transporter {ECO:0000303|PubMed:17491011, ECO:0000303|PubMed:23667501};
DE Short=SOAT {ECO:0000303|PubMed:23667501};
DE AltName: Full=Solute carrier family 10 member 6 {ECO:0000303|PubMed:17491011};
DE Short=SLC10A6 {ECO:0000303|PubMed:17491011};
GN Name=SLC10A6; Synonyms=SOAT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TRANSPORTER ACTIVITY,
RP BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, GLYCOSYLATION, AND
RP PROBABLE MEMBRANE TOPOLOGY.
RC TISSUE=Adrenal gland, and Testis;
RX PubMed=17491011; DOI=10.1074/jbc.m702663200;
RA Geyer J., Doering B., Meerkamp K., Ugele B., Bakhiya N., Fernandes C.F.,
RA Godoy J.R., Glatt H., Petzinger E.;
RT "Cloning and functional characterization of human sodium-dependent organic
RT anion transporter (SLC10A6).";
RL J. Biol. Chem. 282:19728-19741(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-114.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, TRANSPORTER ACTIVITY, TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RX PubMed=23667501; DOI=10.1371/journal.pone.0062638;
RA Fietz D., Bakhaus K., Wapelhorst B., Grosser G., Guenther S., Alber J.,
RA Doering B., Kliesch S., Weidner W., Galuska C.E., Hartmann M.F., Wudy S.A.,
RA Bergmann M., Geyer J.;
RT "Membrane transporters for sulfated steroids in the human testis--cellular
RT localization, expression pattern and functional analysis.";
RL PLoS ONE 8:e62638-e62638(2013).
RN [5]
RP FUNCTION, TRANSPORTER ACTIVITY, AND BIOPHYSICOCHEMICAL PROPERTIES.
RX PubMed=24717977; DOI=10.1016/j.jsbmb.2014.03.013;
RA Schweigmann H., Sanchez-Guijo A., Ugele B., Hartmann K., Hartmann M.F.,
RA Bergmann M., Pfarrer C., Doering B., Wudy S.A., Petzinger E., Geyer J.,
RA Grosser G.;
RT "Transport of the placental estriol precursor 16alpha-hydroxy-
RT dehydroepiandrosterone sulfate (16alpha-OH-DHEAS) by stably transfected
RT OAT4-, SOAT-, and NTCP-HEK293 cells.";
RL J. Steroid Biochem. Mol. Biol. 143:259-265(2014).
RN [6]
RP FUNCTION, AND TRANSPORTER ACTIVITY.
RX PubMed=28951227; DOI=10.1016/j.jsbmb.2017.09.013;
RA Grosser G., Bennien J., Sanchez-Guijo A., Bakhaus K., Doering B.,
RA Hartmann M., Wudy S.A., Geyer J.;
RT "Transport of steroid 3-sulfates and steroid 17-sulfates by the sodium-
RT dependent organic anion transporter SOAT (SLC10A6).";
RL J. Steroid Biochem. Mol. Biol. 179:20-25(2018).
CC -!- FUNCTION: Transports sulfoconjugated steroid hormones from the
CC extracellular compartment into the cytosol in a sodium-dependent manner
CC without hydrolysis (PubMed:17491011, PubMed:23667501, PubMed:24717977,
CC PubMed:28951227). Steroid sulfate hormones are commonly considered to
CC be biologically inactive metabolites, that may be activated by steroid
CC sulfatases into free steroids (PubMed:23667501, PubMed:24717977). May
CC play an important role by delivering sulfoconjugated steroids to
CC specific target cells in reproductive organs (By similarity). May play
CC a role transporting the estriol precursor 16alpha-
CC hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal
CC blood vessel endothelium (PubMed:24717977). Can also transport other
CC sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and
CC sulfoconjugated pyrenes (PubMed:17491011).
CC {ECO:0000250|UniProtKB:Q9CXB2, ECO:0000269|PubMed:17491011,
CC ECO:0000269|PubMed:23667501, ECO:0000269|PubMed:24717977,
CC ECO:0000269|PubMed:28951227}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in)
CC + 2 Na(+)(in); Xref=Rhea:RHEA:71083, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:60050; Evidence={ECO:0000269|PubMed:17491011,
CC ECO:0000269|PubMed:23667501};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-
CC estradiol 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71087,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:136582;
CC Evidence={ECO:0000269|PubMed:23667501, ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) =
CC dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:71091, ChEBI:CHEBI:29101, ChEBI:CHEBI:57905;
CC Evidence={ECO:0000269|PubMed:17491011, ECO:0000269|PubMed:23667501,
CC ECO:0000269|PubMed:24717977};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-
CC ene-diol 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71099,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:190287;
CC Evidence={ECO:0000269|PubMed:23667501};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + pregnenolone sulfate(out) = 2 Na(+)(in) +
CC pregnenolone sulfate(in); Xref=Rhea:RHEA:71095, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:133000; Evidence={ECO:0000269|PubMed:17491011,
CC ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurolithocholate 3-sulfate(out) = 2 Na(+)(in)
CC + taurolithocholate 3-sulfate(in); Xref=Rhea:RHEA:71275,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:58301;
CC Evidence={ECO:0000269|PubMed:17491011};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone
CC 3alpha-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71351,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:133003;
CC Evidence={ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) =
CC 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:71355, ChEBI:CHEBI:29101, ChEBI:CHEBI:136982;
CC Evidence={ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta-
CC estradiol 17-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71359,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:190469;
CC Evidence={ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) =
CC 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:71363, ChEBI:CHEBI:29101, ChEBI:CHEBI:133742;
CC Evidence={ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=epiandrosterone 3-sulfate(out) + 2 Na(+)(out) =
CC epiandrosterone 3-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71367,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:133729;
CC Evidence={ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=epitestosterone 17-sulfate(out) + 2 Na(+)(out) =
CC epitestosterone 17-sulfate(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71371,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:190485;
CC Evidence={ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + testosterone 17-sulfate(out) = 2 Na(+)(in) +
CC testosterone 17-sulfate(in); Xref=Rhea:RHEA:71375, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:190489; Evidence={ECO:0000269|PubMed:28951227};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2
CC Na(+)(out) = 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2
CC Na(+)(in); Xref=Rhea:RHEA:71391, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:87538; Evidence={ECO:0000269|PubMed:24717977};
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=28.7 uM for dehydroepiandrosterone 3-sulfate (DHEAS)
CC {ECO:0000269|PubMed:17491011};
CC KM=12.0 uM for estrone 3-sulfate (E1S) {ECO:0000269|PubMed:17491011};
CC KM=11.3 uM for pregnenolone sulfate (PREGS)
CC {ECO:0000269|PubMed:17491011};
CC KM=319.0 uM for 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-
CC OH-DHEAS) {ECO:0000269|PubMed:24717977};
CC Vmax=1465.8 pmol/min/mg enzyme with 16alpha-
CC hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) as substrate
CC {ECO:0000269|PubMed:24717977};
CC Vmax=1899 pmol/min/mg enzyme with dehydroepiandrosterone 3-sulfate
CC (DHEAS) as substrate {ECO:0000269|PubMed:17491011};
CC Vmax=585 pmol/min/mg enzyme with estrone 3-sulfate (E1S) as substrate
CC {ECO:0000269|PubMed:17491011};
CC Vmax=21685 pmol/min/mg enzyme with pregnenolone sulfate (PREGS) as
CC substrate {ECO:0000269|PubMed:17491011};
CC -!- INTERACTION:
CC Q3KNW5; Q9ULC5: ACSL5; NbExp=3; IntAct=EBI-18159983, EBI-2876927;
CC Q3KNW5; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-18159983, EBI-12109402;
CC Q3KNW5; P05090: APOD; NbExp=3; IntAct=EBI-18159983, EBI-715495;
CC Q3KNW5; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-18159983, EBI-714543;
CC Q3KNW5; Q9H2C2: ARV1; NbExp=3; IntAct=EBI-18159983, EBI-11724186;
CC Q3KNW5; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-18159983, EBI-12069500;
CC Q3KNW5; O95393: BMP10; NbExp=3; IntAct=EBI-18159983, EBI-3922513;
CC Q3KNW5; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-18159983, EBI-8648738;
CC Q3KNW5; Q96F05: C11orf24; NbExp=3; IntAct=EBI-18159983, EBI-2836238;
CC Q3KNW5; O14523: C2CD2L; NbExp=3; IntAct=EBI-18159983, EBI-12822627;
CC Q3KNW5; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-18159983, EBI-9083477;
CC Q3KNW5; P13236: CCL4; NbExp=3; IntAct=EBI-18159983, EBI-2873970;
CC Q3KNW5; O14735: CDIPT; NbExp=3; IntAct=EBI-18159983, EBI-358858;
CC Q3KNW5; Q92903: CDS1; NbExp=3; IntAct=EBI-18159983, EBI-13295305;
CC Q3KNW5; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-18159983, EBI-11959453;
CC Q3KNW5; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-18159983, EBI-11522780;
CC Q3KNW5; O95406: CNIH1; NbExp=3; IntAct=EBI-18159983, EBI-12172273;
CC Q3KNW5; P29400-2: COL4A5; NbExp=3; IntAct=EBI-18159983, EBI-12211159;
CC Q3KNW5; P21964: COMT; NbExp=3; IntAct=EBI-18159983, EBI-372265;
CC Q3KNW5; Q5RI15: COX20; NbExp=3; IntAct=EBI-18159983, EBI-2834035;
CC Q3KNW5; O43169: CYB5B; NbExp=3; IntAct=EBI-18159983, EBI-1058710;
CC Q3KNW5; P00387: CYB5R3; NbExp=3; IntAct=EBI-18159983, EBI-1046040;
CC Q3KNW5; P78329: CYP4F2; NbExp=3; IntAct=EBI-18159983, EBI-1752413;
CC Q3KNW5; Q9BUN8: DERL1; NbExp=3; IntAct=EBI-18159983, EBI-398977;
CC Q3KNW5; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-18159983, EBI-12831978;
CC Q3KNW5; Q9BV81: EMC6; NbExp=3; IntAct=EBI-18159983, EBI-2820492;
CC Q3KNW5; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-18159983, EBI-711490;
CC Q3KNW5; Q7L5A8: FA2H; NbExp=3; IntAct=EBI-18159983, EBI-11337888;
CC Q3KNW5; Q92520: FAM3C; NbExp=3; IntAct=EBI-18159983, EBI-2876774;
CC Q3KNW5; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-18159983, EBI-12142299;
CC Q3KNW5; Q9Y3D6: FIS1; NbExp=3; IntAct=EBI-18159983, EBI-3385283;
CC Q3KNW5; Q14318: FKBP8; NbExp=3; IntAct=EBI-18159983, EBI-724839;
CC Q3KNW5; Q01740: FMO1; NbExp=3; IntAct=EBI-18159983, EBI-12701460;
CC Q3KNW5; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-18159983, EBI-714482;
CC Q3KNW5; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-18159983, EBI-12175685;
CC Q3KNW5; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-18159983, EBI-713304;
CC Q3KNW5; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-18159983, EBI-11991950;
CC Q3KNW5; O95452: GJB6; NbExp=3; IntAct=EBI-18159983, EBI-13345609;
CC Q3KNW5; P16278: GLB1; NbExp=3; IntAct=EBI-18159983, EBI-989638;
CC Q3KNW5; Q9Y3E0: GOLT1B; NbExp=3; IntAct=EBI-18159983, EBI-4402607;
CC Q3KNW5; O14653: GOSR2; NbExp=3; IntAct=EBI-18159983, EBI-4401517;
CC Q3KNW5; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-18159983, EBI-11955647;
CC Q3KNW5; P02724: GYPA; NbExp=3; IntAct=EBI-18159983, EBI-702665;
CC Q3KNW5; P04921: GYPC; NbExp=3; IntAct=EBI-18159983, EBI-7797098;
CC Q3KNW5; Q9BUP3-3: HTATIP2; NbExp=3; IntAct=EBI-18159983, EBI-12937691;
CC Q3KNW5; P24593: IGFBP5; NbExp=3; IntAct=EBI-18159983, EBI-720480;
CC Q3KNW5; P11215: ITGAM; NbExp=3; IntAct=EBI-18159983, EBI-2568251;
CC Q3KNW5; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-18159983, EBI-12033434;
CC Q3KNW5; P48449: LSS; NbExp=3; IntAct=EBI-18159983, EBI-3930711;
CC Q3KNW5; Q13021: MALL; NbExp=3; IntAct=EBI-18159983, EBI-750078;
CC Q3KNW5; Q6N075: MFSD5; NbExp=3; IntAct=EBI-18159983, EBI-3920969;
CC Q3KNW5; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-18159983, EBI-2858252;
CC Q3KNW5; A0A0C4DFN3: MGLL; NbExp=3; IntAct=EBI-18159983, EBI-12866138;
CC Q3KNW5; P11836: MS4A1; NbExp=3; IntAct=EBI-18159983, EBI-2808234;
CC Q3KNW5; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-18159983, EBI-2863634;
CC Q3KNW5; Q99519: NEU1; NbExp=3; IntAct=EBI-18159983, EBI-721517;
CC Q3KNW5; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-18159983, EBI-10317425;
CC Q3KNW5; Q8IXM6: NRM; NbExp=3; IntAct=EBI-18159983, EBI-10262547;
CC Q3KNW5; Q8NG98: OR7D4; NbExp=3; IntAct=EBI-18159983, EBI-18164026;
CC Q3KNW5; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-18159983, EBI-1054848;
CC Q3KNW5; Q99650: OSMR; NbExp=3; IntAct=EBI-18159983, EBI-2804080;
CC Q3KNW5; I3L0A0: PEDS1-UBE2V1; NbExp=3; IntAct=EBI-18159983, EBI-12213001;
CC Q3KNW5; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-18159983, EBI-981985;
CC Q3KNW5; Q86T03: PIP4P1; NbExp=3; IntAct=EBI-18159983, EBI-6164623;
CC Q3KNW5; Q8N4L2: PIP4P2; NbExp=3; IntAct=EBI-18159983, EBI-2820617;
CC Q3KNW5; Q9Y342: PLLP; NbExp=3; IntAct=EBI-18159983, EBI-3919291;
CC Q3KNW5; P60201-2: PLP1; NbExp=3; IntAct=EBI-18159983, EBI-12188331;
CC Q3KNW5; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-18159983, EBI-8652812;
CC Q3KNW5; O60831: PRAF2; NbExp=3; IntAct=EBI-18159983, EBI-2506064;
CC Q3KNW5; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-18159983, EBI-722696;
CC Q3KNW5; P49768-2: PSEN1; NbExp=3; IntAct=EBI-18159983, EBI-11047108;
CC Q3KNW5; Q9NZ42: PSENEN; NbExp=3; IntAct=EBI-18159983, EBI-998468;
CC Q3KNW5; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-18159983, EBI-13044680;
CC Q3KNW5; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-18159983, EBI-10244780;
CC Q3KNW5; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-18159983, EBI-8636004;
CC Q3KNW5; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-18159983, EBI-3917235;
CC Q3KNW5; Q969E2: SCAMP4; NbExp=3; IntAct=EBI-18159983, EBI-4403649;
CC Q3KNW5; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-18159983, EBI-2695784;
CC Q3KNW5; O00767: SCD; NbExp=3; IntAct=EBI-18159983, EBI-2684237;
CC Q3KNW5; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-18159983, EBI-10329948;
CC Q3KNW5; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-18159983, EBI-749270;
CC Q3KNW5; O95562: SFT2D2; NbExp=3; IntAct=EBI-18159983, EBI-4402330;
CC Q3KNW5; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-18159983, EBI-355861;
CC Q3KNW5; Q9Y666-2: SLC12A7; NbExp=3; IntAct=EBI-18159983, EBI-12854384;
CC Q3KNW5; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-18159983, EBI-10281975;
CC Q3KNW5; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-18159983, EBI-8644112;
CC Q3KNW5; Q99726: SLC30A3; NbExp=3; IntAct=EBI-18159983, EBI-10294651;
CC Q3KNW5; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-18159983, EBI-17295964;
CC Q3KNW5; Q8TBE7: SLC35G2; NbExp=3; IntAct=EBI-18159983, EBI-727304;
CC Q3KNW5; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-18159983, EBI-9978441;
CC Q3KNW5; Q13433-2: SLC39A6; NbExp=3; IntAct=EBI-18159983, EBI-12956703;
CC Q3KNW5; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-18159983, EBI-2823239;
CC Q3KNW5; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-18159983, EBI-12266234;
CC Q3KNW5; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-18159983, EBI-3907610;
CC Q3KNW5; P30825: SLC7A1; NbExp=3; IntAct=EBI-18159983, EBI-4289564;
CC Q3KNW5; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-18159983, EBI-10226799;
CC Q3KNW5; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-18159983, EBI-12188413;
CC Q3KNW5; Q6UX34: SNORC; NbExp=3; IntAct=EBI-18159983, EBI-11957067;
CC Q3KNW5; P02808: STATH; NbExp=3; IntAct=EBI-18159983, EBI-738687;
CC Q3KNW5; Q86Y82: STX12; NbExp=3; IntAct=EBI-18159983, EBI-2691717;
CC Q3KNW5; O15400: STX7; NbExp=3; IntAct=EBI-18159983, EBI-3221827;
CC Q3KNW5; Q9UNK0: STX8; NbExp=3; IntAct=EBI-18159983, EBI-727240;
CC Q3KNW5; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-18159983, EBI-12187159;
CC Q3KNW5; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-18159983, EBI-1049004;
CC Q3KNW5; Q03518: TAP1; NbExp=3; IntAct=EBI-18159983, EBI-747259;
CC Q3KNW5; Q9NZ01: TECR; NbExp=3; IntAct=EBI-18159983, EBI-2877718;
CC Q3KNW5; P02787: TF; NbExp=3; IntAct=EBI-18159983, EBI-714319;
CC Q3KNW5; P48230: TM4SF4; NbExp=3; IntAct=EBI-18159983, EBI-8650934;
CC Q3KNW5; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-18159983, EBI-12845616;
CC Q3KNW5; P17152: TMEM11; NbExp=3; IntAct=EBI-18159983, EBI-723946;
CC Q3KNW5; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-18159983, EBI-10171534;
CC Q3KNW5; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-18159983, EBI-10694905;
CC Q3KNW5; Q96AN5: TMEM143; NbExp=3; IntAct=EBI-18159983, EBI-13342951;
CC Q3KNW5; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-18159983, EBI-2800360;
CC Q3KNW5; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-18159983, EBI-2339195;
CC Q3KNW5; Q969S6: TMEM203; NbExp=3; IntAct=EBI-18159983, EBI-12274070;
CC Q3KNW5; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-18159983, EBI-12876824;
CC Q3KNW5; A2RU14: TMEM218; NbExp=3; IntAct=EBI-18159983, EBI-10173151;
CC Q3KNW5; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-18159983, EBI-12195227;
CC Q3KNW5; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-18159983, EBI-8642211;
CC Q3KNW5; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-18159983, EBI-11528917;
CC Q3KNW5; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-18159983, EBI-10315004;
CC Q3KNW5; Q8N6L7: TMEM252; NbExp=3; IntAct=EBI-18159983, EBI-8787626;
CC Q3KNW5; E9PQX1: TMEM262; NbExp=3; IntAct=EBI-18159983, EBI-17180389;
CC Q3KNW5; P56557: TMEM50B; NbExp=3; IntAct=EBI-18159983, EBI-12366453;
CC Q3KNW5; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-18159983, EBI-2852148;
CC Q3KNW5; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-18159983, EBI-6656213;
CC Q3KNW5; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-18159983, EBI-12015604;
CC Q3KNW5; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-18159983, EBI-2548832;
CC Q3KNW5; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-18159983, EBI-17249488;
CC Q3KNW5; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-18159983, EBI-16746122;
CC Q3KNW5; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-18159983, EBI-12003468;
CC Q3KNW5; O60636: TSPAN2; NbExp=3; IntAct=EBI-18159983, EBI-3914288;
CC Q3KNW5; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-18159983, EBI-12195249;
CC Q3KNW5; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-18159983, EBI-11343401;
CC Q3KNW5; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-18159983, EBI-988826;
CC Q3KNW5; Q53HI1: UNC50; NbExp=3; IntAct=EBI-18159983, EBI-7601760;
CC Q3KNW5; O75379: VAMP4; NbExp=3; IntAct=EBI-18159983, EBI-744953;
CC Q3KNW5; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-18159983, EBI-7850136;
CC Q3KNW5; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-18159983, EBI-751204;
CC Q3KNW5; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-18159983, EBI-751210;
CC Q3KNW5; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-18159983, EBI-12837904;
CC Q3KNW5; O95159: ZFPL1; NbExp=3; IntAct=EBI-18159983, EBI-718439;
CC Q3KNW5; Q96FB2; NbExp=3; IntAct=EBI-18159983, EBI-2857623;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23667501}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis, placenta and pancreas.
CC Moderately expressed in heart, lung and mammary gland. Weakly expressed
CC in brain, colon, kidney, liver, ovary, prostate, small intestine,
CC spleen and thymus. {ECO:0000269|PubMed:17491011,
CC ECO:0000269|PubMed:23667501}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:17491011}.
CC -!- MISCELLANEOUS: In humans, 3-beta-sulfooxy-androst-5-en-17-one (DHEAS)
CC is the most abundant circulating steroid sulfate in the human body, it
CC is mainly synthesized from adrenal glands and gonads, whereas rats and
CC mice have low circulating concentrations of DHEAS in the periphery as
CC they can only produce DHEAS in their gonads.
CC {ECO:0000250|UniProtKB:Q9CXB2}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000305}.
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DR EMBL; EF437223; ABO38126.1; -; mRNA.
DR EMBL; AJ583502; CAE47477.1; -; mRNA.
DR EMBL; CH471057; EAX05969.1; -; Genomic_DNA.
DR EMBL; BC107051; AAI07052.1; -; mRNA.
DR EMBL; BC107052; AAI07053.1; -; mRNA.
DR CCDS; CCDS3614.1; -.
DR RefSeq; NP_932069.1; NM_197965.2.
DR AlphaFoldDB; Q3KNW5; -.
DR SMR; Q3KNW5; -.
DR BioGRID; 131345; 148.
DR IntAct; Q3KNW5; 145.
DR STRING; 9606.ENSP00000273905; -.
DR DrugBank; DB05804; Prasterone sulfate.
DR DrugBank; DB02789; Pregnenolone.
DR TCDB; 2.A.28.1.4; the bile acid:na(+) symporter (bass) family.
DR GlyGen; Q3KNW5; 2 sites.
DR BioMuta; SLC10A6; -.
DR DMDM; 160358735; -.
DR PaxDb; Q3KNW5; -.
DR PeptideAtlas; Q3KNW5; -.
DR PRIDE; Q3KNW5; -.
DR Antibodypedia; 14387; 47 antibodies from 13 providers.
DR DNASU; 345274; -.
DR Ensembl; ENST00000273905.7; ENSP00000273905.6; ENSG00000145283.8.
DR GeneID; 345274; -.
DR KEGG; hsa:345274; -.
DR MANE-Select; ENST00000273905.7; ENSP00000273905.6; NM_197965.3; NP_932069.1.
DR UCSC; uc003hqd.2; human.
DR CTD; 345274; -.
DR DisGeNET; 345274; -.
DR GeneCards; SLC10A6; -.
DR HGNC; HGNC:30603; SLC10A6.
DR HPA; ENSG00000145283; Tissue enhanced (esophagus, skin).
DR MIM; 613366; gene.
DR neXtProt; NX_Q3KNW5; -.
DR OpenTargets; ENSG00000145283; -.
DR PharmGKB; PA142670910; -.
DR VEuPathDB; HostDB:ENSG00000145283; -.
DR eggNOG; KOG2718; Eukaryota.
DR GeneTree; ENSGT00950000182808; -.
DR HOGENOM; CLU_034788_7_5_1; -.
DR InParanoid; Q3KNW5; -.
DR OMA; KWPKQSK; -.
DR OrthoDB; 1148347at2759; -.
DR PhylomeDB; Q3KNW5; -.
DR TreeFam; TF315811; -.
DR PathwayCommons; Q3KNW5; -.
DR Reactome; R-HSA-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR SignaLink; Q3KNW5; -.
DR BioGRID-ORCS; 345274; 7 hits in 1061 CRISPR screens.
DR GenomeRNAi; 345274; -.
DR Pharos; Q3KNW5; Tdark.
DR PRO; PR:Q3KNW5; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q3KNW5; protein.
DR Bgee; ENSG00000145283; Expressed in skin of abdomen and 82 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0043250; F:sodium-dependent organic anion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR GO; GO:0043251; P:sodium-dependent organic anion transport; IEA:Ensembl.
DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR030203; SLC10A6.
DR PANTHER; PTHR10361; PTHR10361; 1.
DR PANTHER; PTHR10361:SF55; PTHR10361:SF55; 1.
DR Pfam; PF01758; SBF; 1.
DR TIGRFAMs; TIGR00841; bass; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Ion transport; Lipid transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..377
FT /note="Sodium-dependent organic anion transporter"
FT /id="PRO_0000309215"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..266
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..377
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 6
FT /note="S -> F (in dbSNP:rs17694522)"
FT /id="VAR_036904"
FT VARIANT 114
FT /note="I -> V (in dbSNP:rs13106574)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_036905"
SQ SEQUENCE 377 AA; 41259 MW; A68B0F034B5BE83F CRC64;
MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG CSVEIRKLWS
HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV LIMGCCPGGT ISNIFTFWVD
GDMDLSISMT TCSTVAALGM MPLCIYLYTW SWSLQQNLTI PYQNIGITLV CLTIPVAFGV
YVNYRWPKQS KIILKIGAVV GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT
GFLLALFTHQ SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID
GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE GAITPGPPGP
MDCHRALEPV GHITSCE
