ID   SOB1A_XENLA             Reviewed;         203 AA.
AC   Q6DE02;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=SOSS complex subunit B1-A;
DE   AltName: Full=Nucleic acid-binding protein 2-A;
DE   AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 2B-A;
DE   AltName: Full=Sensor of single-strand DNA complex subunit B1-A;
DE   AltName: Full=Sensor of ssDNA subunit B1-A;
DE            Short=SOSS-B1-A;
DE   AltName: Full=Single-stranded DNA-binding protein 1-A;
GN   Name=nabp2-a; Synonyms=obfc2b-a, ssb1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. In the SOSS complex, acts as a sensor of single-stranded
CC       DNA that binds to single-stranded DNA. The SOSS complex associates with
CC       DNA lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SOSS complex, composed of soss-b (soss-
CC       b1/nabp2 or soss-b2/nabp1), soss-a/ints3 and soss-c/inip. SOSS
CC       complexes containing soss-b1/nabp2 are more abundant than complexes
CC       containing soss-b2/nabp1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-B family. SOSS-B1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC077346; AAH77346.1; -; mRNA.
DR   RefSeq; NP_001086717.1; NM_001093248.1.
DR   RefSeq; XP_018100604.1; XM_018245115.1.
DR   AlphaFoldDB; Q6DE02; -.
DR   SMR; Q6DE02; -.
DR   DNASU; 446552; -.
DR   GeneID; 446552; -.
DR   KEGG; xla:446552; -.
DR   CTD; 446552; -.
DR   Xenbase; XB-GENE-985194; nabp2.L.
DR   OMA; HARTLSC; -.
DR   OrthoDB; 1512483at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 446552; Expressed in lung and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0044818; P:mitotic G2/M transition checkpoint; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..203
FT                   /note="SOSS complex subunit B1-A"
FT                   /id="PRO_0000333962"
FT   DNA_BIND        22..92
FT                   /note="OB"
FT   REGION          110..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   203 AA;  21660 MW;  8693F9EF457BBCDA CRC64;
     MTTETFVKDV KPGLKNLSVL FIVLETGRVT KTKDGHEVRT CKVADKTGSI NISVWDELGN
     FIQPGDIIRL SKGYASLFKG CLTLYTGRGG DLQKIGEFCM VYSEVPNFSE PNPEYIAQQS
     QSKQGQQESG TGTNNHNSSS PAPPASDLEN GNGSNSSGPP AHQSTAPAHS ASGRITRSQP
     NHSLPGAPNS VSNGKESRRT GKR