ID   SOB1B_XENLA             Reviewed;         203 AA.
AC   Q6NRF9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=SOSS complex subunit B1-B;
DE   AltName: Full=Nucleic acid-binding protein 2-B;
DE   AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 2B-B;
DE   AltName: Full=Sensor of single-strand DNA complex subunit B1-B;
DE   AltName: Full=Sensor of ssDNA subunit B1-B;
DE            Short=SOSS-B1-B;
DE   AltName: Full=Single-stranded DNA-binding protein 1-B;
GN   Name=nabp2-b; Synonyms=obfc2b-b, ssb1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. In the SOSS complex, acts as a sensor of single-stranded
CC       DNA that binds to single-stranded DNA. The SOSS complex associates with
CC       DNA lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SOSS complex, composed of soss-b (soss-
CC       b1/nabp2 or soss-b2/nabp1), soss-a/ints3 and soss-c/inip. SOSS
CC       complexes containing soss-b1/nabp2 are more abundant than complexes
CC       containing soss-b2/nabp1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-B family. SOSS-B1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC070793; AAH70793.1; -; mRNA.
DR   RefSeq; NP_001084896.1; NM_001091427.1.
DR   AlphaFoldDB; Q6NRF9; -.
DR   SMR; Q6NRF9; -.
DR   DNASU; 431947; -.
DR   GeneID; 431947; -.
DR   KEGG; xla:431947; -.
DR   CTD; 431947; -.
DR   Xenbase; XB-GENE-6251551; nabp2.S.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 431947; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0044818; P:mitotic G2/M transition checkpoint; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..203
FT                   /note="SOSS complex subunit B1-B"
FT                   /id="PRO_0000333963"
FT   DNA_BIND        22..92
FT                   /note="OB"
FT   REGION          110..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   203 AA;  21679 MW;  825A2CFE2B2B4E64 CRC64;
     MTTETFVKDV KPGLKNLSVL FIVLETGRVT KTKDGHEVRT CKVADKTGTI NISVWDEVGN
     FIQPGDIIRL TKGYASLFKG CLTLYTGRGG DLQKIGEFCM VYSEVPNFSE PNPEYTAQQS
     QNKQAQAESG TGTNNHNSSS PAPPAPDLDN GNGSNSSGPS TNQSTAPAHS TSGRITRSQP
     NHSLPGAPNS VSNGKEPRRT GKR