ID   SOBPA_DANRE             Reviewed;         936 AA.
AC   A5X7A0;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Sine oculis-binding protein homolog A;
DE   AltName: Full=Jackson circler protein 1A;
GN   Name=sobpa; Synonyms=jxc1a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:ABG45863.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Noben-Trauth K.;
RT   "Mutations in Jxc1 cause deafness, vestibular deficits and cochlea
RT   malformation in the Jackson circler (jc) mutant mouse.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Implicated in development of the cochlea.
CC       {ECO:0000250|UniProtKB:Q0P5V2}.
CC   -!- SIMILARITY: Belongs to the SOBP family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ655703; ABG45863.1; -; mRNA.
DR   RefSeq; NP_001092088.1; NM_001098618.1.
DR   AlphaFoldDB; A5X7A0; -.
DR   STRING; 7955.ENSDARP00000070897; -.
DR   PaxDb; A5X7A0; -.
DR   PRIDE; A5X7A0; -.
DR   GeneID; 573683; -.
DR   KEGG; dre:573683; -.
DR   CTD; 573683; -.
DR   ZFIN; ZDB-GENE-090313-313; sobpa.
DR   eggNOG; ENOG502QZ8A; Eukaryota.
DR   InParanoid; A5X7A0; -.
DR   OrthoDB; 184811at2759; -.
DR   PRO; PR:A5X7A0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   InterPro; IPR026092; RAI2/SOBP.
DR   PANTHER; PTHR23186; PTHR23186; 1.
DR   Pfam; PF15279; SOBP; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..936
FT                   /note="Sine oculis-binding protein homolog A"
FT                   /id="PRO_0000312236"
FT   ZN_FING         169..207
FT                   /note="FCS-type 1"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         247..287
FT                   /note="FCS-type 2"
FT                   /evidence="ECO:0000255"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          336..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          842..877
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..424
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..602
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..632
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        848..862
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   936 AA;  99903 MW;  7A529DDF2E2613B4 CRC64;
     MAEMEKEGRP PESKRSRKPA HPVKREINAE MKVPSNRPLP GAGQAGNLHG NSPYLMSFAE
     NTMNELLGWY GYDKVELRDS DDIEIRNYPD GEMRQHISVL KENSLPKAST LENSSGSPPH
     ANSSGSTPTS RNGVTAESSV NPSSSKEHGG LPIIVPLIPP PLIKAPAEED SSNVQIMCAW
     CQKVGVKRYS LSMGSELKSF CSEKCFAACR RAYFKRNKLG YVRNCSAREE EGVPTHSLSK
     DTPRLVLKTN SDVLVCDWCK HIRHTKEYLD FGAGERRLQF CSAKCLNQYK MDIFYKETQA
     ALPGGLCNPP LPTSDTKSES GAGVQLLTPE SWSAPLSELR SRKAPSPVGA TIAGPSGSTS
     GSPSEAGTVC SSSSSSSSSS SSTKIPTPRP HESPSLPPPH PPPISGLHPA LGMPPGSPPM
     VMTPRGPVPF PIFMEHQMMQ QMRPPFLRPP GPNSPHSNPM IPGIGPPPPP RTLCPPSSPM
     HRPLLSPHLH PSSTPTLSGN PPGIMPPHPA AHMPGLPFPP VNMMPSGPIP VPPIMNIGMP
     SLAPLVPPPT LLVPYPVIVP LPVPIPIPVP IPYNPQRSGD RPGNDGTLPN TANEQKDSKA
     PPSFSSRGEE RDFQKAPPNS DTLSPEFSKQ TEQGRTNMAD LMVKMENSGK GSSEHSHKDT
     PADGVIDLTT SHRSRQQLVI QRAVTCVQVK AEPGLSPPPA LLGETELDGS TSISTGTAKD
     DHRDTYSNAE SPLASVALPC ADPSYCSGTP PLSQPITCSA SIIPSNITTA KTEPGSATPC
     NVIVNGSCNL PPTESLIRTP PLEQRPQVDT CRRTATVCDE PAGADLEGED LKENSCLATE
     KDSAGKRCSN DQSAITTGTG DDKSQSPEDD PSGEDHAYAL PLMPKPGCVI QPVPKPAEKT
     AAILPCGLTA PLTGTVPMEM EPPLKRRCLR IRNQNK