SOBPB_DANRE
ID SOBPB_DANRE Reviewed; 668 AA.
AC A7XYJ6; Q5RGY3;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Sine oculis-binding protein homolog B;
DE AltName: Full=Jackson circler protein 1B;
GN Name=sobpb; Synonyms=jxc1b; ORFNames=si:ch211-152c2.4;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:ABF56061.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Noben-Trauth K.;
RT "Mutations in Jxc1 are associated with deafness, vestibular deficits and
RT cochlea malformation in the Jackson circler (jc) mutant mouse.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Implicated in development of the cochlea.
CC {ECO:0000250|UniProtKB:Q0P5V2}.
CC -!- SIMILARITY: Belongs to the SOBP family. {ECO:0000255}.
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DR EMBL; DQ503413; ABF56061.1; -; mRNA.
DR EMBL; BX649468; CAI11621.2; -; Genomic_DNA.
DR RefSeq; NP_001108455.1; NM_001114983.2.
DR RefSeq; XP_009298206.1; XM_009299931.2.
DR AlphaFoldDB; A7XYJ6; -.
DR STRING; 7955.ENSDARP00000121838; -.
DR PaxDb; A7XYJ6; -.
DR Ensembl; ENSDART00000135618; ENSDARP00000121838; ENSDARG00000017386.
DR Ensembl; ENSDART00000185280; ENSDARP00000157409; ENSDARG00000017386.
DR GeneID; 100006088; -.
DR KEGG; dre:100006088; -.
DR CTD; 100006088; -.
DR ZFIN; ZDB-GENE-041210-8; sobpb.
DR eggNOG; ENOG502QZ8A; Eukaryota.
DR GeneTree; ENSGT00940000154164; -.
DR HOGENOM; CLU_410998_0_0_1; -.
DR InParanoid; A7XYJ6; -.
DR OMA; HTKYLDF; -.
DR OrthoDB; 184811at2759; -.
DR PhylomeDB; A7XYJ6; -.
DR TreeFam; TF324359; -.
DR PRO; PR:A7XYJ6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000017386; Expressed in muscle tissue and 17 other tissues.
DR ExpressionAtlas; A7XYJ6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR InterPro; IPR026092; RAI2/SOBP.
DR PANTHER; PTHR23186; PTHR23186; 4.
DR Pfam; PF15279; SOBP; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..668
FT /note="Sine oculis-binding protein homolog B"
FT /id="PRO_0000312237"
FT ZN_FING 140..178
FT /note="FCS-type 1"
FT /evidence="ECO:0000255"
FT ZN_FING 218..258
FT /note="FCS-type 2"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..356
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..388
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 74685 MW; B1DD8466632A81C2 CRC64;
MDACRPAEKR SRKPAHPLRR NISEDMKNFA ENTMNELLGW YGYDKVDLQD SEAADARNRV
KRNHISVLKE NAVPKPLNVE KKIPPSSSSS SSSSSSCSSE PVRNGDQDPP TVPVSPSASS
ASPRHNMNVI VPLIKPSAVE DVQNVQIVCV WCQKEGMKRY SLLMGSELKS FCSEKCFAAC
RRAYFKRNKA RDEDRHGDKS PSPGQTLDTP TRLMLKMNNN NSSTRVCDWC KHIRHTKEYL
DFGSGEERLQ FCSTKCLNQY KMDVFYREAR AALTSSKEEE NHPKPAATSE NQTLLTPDAW
ESPAKSLSPQ TPTASALQRT PVCMRVQMAT SPKSPTGPSQ GTPEQPRPPH MPLPFIRPPL
HAQSLRSPTP NLPHNPPHPL SPTQRVPFAP PPHYPLPYLP LHPTFPPQMP PPWPQPMMMM
PYPVFVPIPI PIPIPIPISP QNSHRGVIRS LQEPEKEPAG SQRVKTERCV SPVSASERQV
IQCLRRDSVK EERNDTHIQT LRKALYTSVL TSTASASLDG RIVSPASLYS LARSTAIQAA
SFSLDSSSGQ IPSPLSDCED VKENSYLCGR GNDSANQWTA EQMDCQSDQS KEGKGEEETP
QDVEHTYARS VPPKLREKNT HVNTQTHLHT QIWEKNTQVD ELGPEQSVRD DAEPAVKRRC
LRIRDQNK
