SOBP_BOVIN
ID SOBP_BOVIN Reviewed; 872 AA.
AC A7XYH9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Sine oculis-binding protein homolog;
DE AltName: Full=Jackson circler protein 1;
GN Name=SOBP {ECO:0000250|UniProtKB:Q0P5V2};
GN Synonyms=JXC1 {ECO:0000312|EMBL:ABF56056.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:ABF56056.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Noben-Trauth K.;
RT "Mutations in Jxc1 are associated with deafness, vestibular deficits and
RT cochlea malformation in the Jackson circler (jc) mutant mouse.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Implicated in development of the cochlea.
CC {ECO:0000250|UniProtKB:Q0P5V2}.
CC -!- SUBUNIT: Interacts (via SIM domains) with SUMO1 and SUMO2.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SOBP family. {ECO:0000255}.
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DR EMBL; DQ503408; ABF56056.1; -; mRNA.
DR RefSeq; NP_001094640.2; NM_001101170.2.
DR RefSeq; XP_005210864.1; XM_005210807.3.
DR AlphaFoldDB; A7XYH9; -.
DR STRING; 9913.ENSBTAP00000025519; -.
DR PaxDb; A7XYH9; -.
DR PRIDE; A7XYH9; -.
DR Ensembl; ENSBTAT00000025519; ENSBTAP00000025519; ENSBTAG00000019175.
DR GeneID; 537433; -.
DR KEGG; bta:537433; -.
DR CTD; 55084; -.
DR VEuPathDB; HostDB:ENSBTAG00000019175; -.
DR VGNC; VGNC:35118; SOBP.
DR eggNOG; ENOG502QZ8A; Eukaryota.
DR GeneTree; ENSGT00940000154164; -.
DR InParanoid; A7XYH9; -.
DR OMA; MAPCVIS; -.
DR OrthoDB; 184811at2759; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000019175; Expressed in Ammon's horn and 103 other tissues.
DR ExpressionAtlas; A7XYH9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032184; F:SUMO polymer binding; IEA:Ensembl.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR GO; GO:0090102; P:cochlea development; IEA:Ensembl.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IBA:GO_Central.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR InterPro; IPR026092; RAI2/SOBP.
DR PANTHER; PTHR23186; PTHR23186; 1.
DR Pfam; PF15279; SOBP; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Metal-binding; Phosphoprotein; Reference proteome; Repeat;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..872
FT /note="Sine oculis-binding protein homolog"
FT /id="PRO_0000312231"
FT ZN_FING 142..180
FT /note="FCS-type 1"
FT /evidence="ECO:0000255"
FT ZN_FING 216..256
FT /note="FCS-type 2"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 620..624
FT /note="SUMO interaction motif 1 (SIM); mediates the binding
FT to polysumoylated substrates"
FT /evidence="ECO:0000250"
FT MOTIF 651..655
FT /note="SUMO interaction motif 2 (SIM); mediates the binding
FT to polysumoylated substrates"
FT /evidence="ECO:0000250"
FT COMPBIAS 320..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..444
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..484
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..757
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 629
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0P5V2"
FT MOD_RES 697
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0P5V2"
FT CROSSLNK 675
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:A7XYQ1"
SQ SEQUENCE 872 AA; 92469 MW; F7DBFE8FC98FDA8A CRC64;
MAEMEKEGRP PENKRSRKPA HPVKREINEE MKNFAENTMN ELLGWYGYDK VELKDGEDIE
FRSYPTDGES RQHISVLKEN SLPKPKLPED SVISPYNIST GYSGLATGNG LSDSPAGSKD
HGNVPIIVPL IPPPFIKPPA EDDVSNVQIM CAWCQKVGIK RYSLSMGSEV KSFCSEKCFA
ACRRAYFKRN KARDEDGHAE NFPQQHYAKE TPRLAFKNNC ELLVCDWCKH IRHTKEYLDF
GDGERRLQFC SAKCLNQYKM DIFYKETQAN LPAGLCSTLH PPMENKTEGT GVQLLTPDSW
NIPLTDARRK APSPVAAAGQ SQGPGPSAST TVSPSDTANC SVTKIPTPVP KSMPISETPN
IPPVSVQPPA SIGPPLGVPP RSPPMVMTNR GPVPLPIFME QQIMQQLRPP FIRGPPHHAS
NPNSPLSNPM LPGIGPPPGG PRNLGPTSSP MHRPLLSPHI HPPSTPTMPG NPPGLLPPPP
PGAPLPSLPF PPVSMMPNGP MPVPQMMNFG LPSLAPLVPP PTLLVPYPVI VPLPVPIPIP
IPVPHVSDSK PPNGFSSNGE NFIPSAPGDS SAAGGKPGGH SLSPRDSKQG SSKSADSPPG
CSGQALSLAP APAEHGRSEV VDLTRRAGSP PGAGGQLGFP GGVLQGPQDG VIDLTVGHRA
RLHNVIHRAL HAHVKAEREP GAAERRTCGG CRDGHCSPPA AGDPGPGAPA GPEAAAACNV
IVNGTRGAAE GAKGAEPPPE QPPPPPPPPP APPKKLLSPE EPAVSELESV KENNCASNCH
LDGEAAKKLM GEEALAGGDK SDPNLNNPAD EDHAYALRML PKTGCVIQPV PKPAEKAAMA
PCIISSPMLS AGPEDLEPPL KRRCLRIRNQ NK
