ID   SOBP_CHICK              Reviewed;         873 AA.
AC   A7XYH5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Sine oculis-binding protein homolog;
DE   AltName: Full=Jackson circler protein 1;
GN   Name=SOBP {ECO:0000250|UniProtKB:Q0P5V2};
GN   Synonyms=JXC1 {ECO:0000312|EMBL:ABF56055.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000312|EMBL:ABF56055.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Noben-Trauth K.;
RT   "Mutations in Jxc1 are associated with deafness, vestibular deficits and
RT   cochlea malformation in the Jackson circler (jc) mutant mouse.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Implicated in development of the cochlea.
CC       {ECO:0000250|UniProtKB:Q0P5V2}.
CC   -!- SIMILARITY: Belongs to the SOBP family. {ECO:0000255}.
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DR   EMBL; DQ503407; ABF56055.1; -; mRNA.
DR   RefSeq; NP_001103647.1; NM_001110177.1.
DR   RefSeq; XP_015140000.1; XM_015284514.1.
DR   AlphaFoldDB; A7XYH5; -.
DR   STRING; 9031.ENSGALP00000024667; -.
DR   PaxDb; A7XYH5; -.
DR   Ensembl; ENSGALT00000048637; ENSGALP00000054799; ENSGALG00000043047.
DR   GeneID; 421775; -.
DR   KEGG; gga:421775; -.
DR   CTD; 55084; -.
DR   VEuPathDB; HostDB:geneid_421775; -.
DR   eggNOG; ENOG502QZ8A; Eukaryota.
DR   GeneTree; ENSGT00940000154164; -.
DR   HOGENOM; CLU_012732_0_0_1; -.
DR   InParanoid; A7XYH5; -.
DR   OMA; MAPCVIS; -.
DR   OrthoDB; 184811at2759; -.
DR   PhylomeDB; A7XYH5; -.
DR   PRO; PR:A7XYH5; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000043047; Expressed in cerebellum and 12 other tissues.
DR   ExpressionAtlas; A7XYH5; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032184; F:SUMO polymer binding; IEA:Ensembl.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0090102; P:cochlea development; IEA:Ensembl.
DR   GO; GO:0050890; P:cognition; IEA:Ensembl.
DR   GO; GO:0042472; P:inner ear morphogenesis; IBA:GO_Central.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR026092; RAI2/SOBP.
DR   PANTHER; PTHR23186; PTHR23186; 1.
DR   Pfam; PF15279; SOBP; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..873
FT                   /note="Sine oculis-binding protein homolog"
FT                   /id="PRO_0000312235"
FT   ZN_FING         142..180
FT                   /note="FCS-type 1"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         216..256
FT                   /note="FCS-type 2"
FT                   /evidence="ECO:0000255"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..766
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          779..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..444
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..485
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   873 AA;  94058 MW;  858EBC3C5747F507 CRC64;
     MAEMEKEGRP PENKRSRKPA HPVKREINEE MKNFAENTMN ELLGWYGYDK VELKDGEDIE
     FRNYSADGES RQHISVLKEN SLPKPKLPED SVISPYNINT SYPGLATGNG LSDSPAGSKD
     HGNVPIIVPL IPPPFIKPPA EDDVSNVQIM CAWCQKVGIK RYSLSMGSEV KCFCSEKCFA
     ACRRAYFKRN KARDEDGHAE NFPQQHYAKE TPRLAFKNNC ELLVCDWCKH IRHTKEYLDF
     GDGERRLQFC SAKCLNQYKM DIFYKETQAN LPAGLCSTLH PPVENKAEGT GVQLLTPDSW
     NIPLADARRK APSPASAAGQ IQGPGPSAST TASPSDTANC SVTKIPTPVP KPIPISENPN
     IPPVSVQPPA SIVPPIGVPP RSPPMVMTNR GPVPLPIFME QQIMQQIRPP FIRGPPHHAS
     NPNSPLSNPM IPGIGPPPGG PRNMGPTSSP MHRPMLSPHI HPPTTPTMPG NPPGLLPPPP
     PGAPLPSLPF PPVSMMPNGP MPMPQMMNFG LPSLAPLVPP PTLLVPYPVI VPLPVPIPIP
     IPIPHINDSK PPSGFSSNGE NFIPSNSSET PGGKPPNSSS SPRESKQGSS KPSDSSPSCS
     GQSLNQAQVL QEHSKNEVVD LTVRPSSPVN SKFGFPSVLQ GPQDGVIDLT VGHRSRLHNV
     IHRALHAQVK VEREPNSVVN LAFGSSDKRN CSDCRDNCSP VDSKTLPCGD AAHCCPVSLA
     SGTPGLEAGA AVCNVIVNGT KSTEGSKNPE PPQDPKKPQP PEELAVSELE SVKENNCASN
     CHLEGDTGKK AGEEPLAGGD KQDPNLNNPA DEDHAYALRM LPKTGCVIQP VPKPAEKTAI
     APCIMSTPIL STGPEDLEPP LKRRCLRIRN QNK