SOC1_ARATH
ID SOC1_ARATH Reviewed; 214 AA.
AC O64645;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=MADS-box protein SOC1 {ECO:0000303|PubMed:15805477, ECO:0000303|PubMed:17428825, ECO:0000303|PubMed:18339670};
DE AltName: Full=Agamous-like MADS-box protein AGL20 {ECO:0000303|PubMed:10995392, ECO:0000303|PubMed:11123798};
DE AltName: Full=Protein SUPPRESSOR OF CONSTANS OVEREXPRESSION 1 {ECO:0000303|PubMed:15805477, ECO:0000303|PubMed:17428825, ECO:0000303|PubMed:18339670};
GN Name=SOC1 {ECO:0000303|PubMed:15805477, ECO:0000303|PubMed:17428825,
GN ECO:0000303|PubMed:18339670};
GN Synonyms=AGL20 {ECO:0000303|PubMed:10995392, ECO:0000303|PubMed:11123798};
GN OrderedLocusNames=At2g45660 {ECO:0000312|Araport:AT2G45660};
GN ORFNames=F17K2.19 {ECO:0000312|EMBL:AAC06175.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DISRUPTION PHENOTYPE.
RX PubMed=11123798; DOI=10.1046/j.1365-313x.2000.00906.x;
RA Borner R., Kampmann G., Chandler J., Gleissner R., Wisman E., Apel K.,
RA Melzer S.;
RT "A MADS domain gene involved in the transition to flowering in
RT Arabidopsis.";
RL Plant J. 24:591-599(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=10995392; DOI=10.1101/gad.813600;
RA Lee H., Suh S.S., Park E., Cho E., Ahn J.H., Kim S.G., Lee J.S., Kwon Y.M.,
RA Lee I.;
RT "The AGAMOUS-LIKE 20 MADS domain protein integrates floral inductive
RT pathways in Arabidopsis.";
RL Genes Dev. 14:2366-2376(2000).
RN [6]
RP INTERACTION WITH AGL15; AGL16 AND AGL19.
RX PubMed=15805477; DOI=10.1105/tpc.105.031831;
RA de Folter S., Immink R.G.H., Kieffer M., Parenicova L., Henz S.R.,
RA Weigel D., Busscher M., Kooiker M., Colombo L., Kater M.M., Davies B.,
RA Angenent G.C.;
RT "Comprehensive interaction map of the Arabidopsis MADS Box transcription
RT factors.";
RL Plant Cell 17:1424-1433(2005).
RN [7]
RP INDUCTION BY AP1.
RX PubMed=17428825; DOI=10.1242/dev.003103;
RA Liu C., Zhou J., Bracha-Drori K., Yalovsky S., Ito T., Yu H.;
RT "Specification of Arabidopsis floral meristem identity by repression of
RT flowering time genes.";
RL Development 134:1901-1910(2007).
RN [8]
RP FUNCTION, AND INDUCTION BY AGL24.
RX PubMed=18339670; DOI=10.1242/dev.020255;
RA Liu C., Chen H., Er H.L., Soo H.M., Kumar P.P., Han J.-H., Liou Y.C.,
RA Yu H.;
RT "Direct interaction of AGL24 and SOC1 integrates flowering signals in
RT Arabidopsis.";
RL Development 135:1481-1491(2008).
RN [9]
RP REVIEW.
RX PubMed=18390846; DOI=10.1093/jxb/ern070;
RA Alexandre C.M., Hennig L.;
RT "FLC or not FLC: the other side of vernalization.";
RL J. Exp. Bot. 59:1127-1135(2008).
RN [10]
RP FUNCTION, MUTAGENESIS OF ARG-24; GLU-34 AND GLY-113, INTERACTION WITH
RP AGL24, AND SUBCELLULAR LOCATION.
RX PubMed=18466303; DOI=10.1111/j.1365-313x.2008.03552.x;
RA Lee J., Oh M., Park H., Lee I.;
RT "SOC1 translocated to the nucleus by interaction with AGL24 directly
RT regulates leafy.";
RL Plant J. 55:832-843(2008).
RN [11]
RP FUNCTION, INDUCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=19656343; DOI=10.1111/j.1365-313x.2009.03985.x;
RA Gregis V., Sessa A., Dorca-Fornell C., Kater M.M.;
RT "The Arabidopsis floral meristem identity genes AP1, AGL24 and SVP directly
RT repress class B and C floral homeotic genes.";
RL Plant J. 60:626-637(2009).
RN [12]
RP INDUCTION.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=25281686; DOI=10.1105/tpc.114.130781;
RA Lopez-Gonzalez L., Mouriz A., Narro-Diego L., Bustos R.,
RA Martinez-Zapater J.M., Jarillo J.A., Pineiro M.;
RT "Chromatin-dependent repression of the Arabidopsis floral integrator genes
RT involves plant specific PHD-containing proteins.";
RL Plant Cell 26:3922-3938(2014).
RN [13]
RP INTERACTION WITH OXS3, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia, and cv. Wassilewskija-4;
RX PubMed=31540691; DOI=10.1016/j.bbrc.2019.08.154;
RA Liang M., Xiao S., Cai J., Ow D.W.;
RT "OXIDATIVE STRESS 3 regulates drought-induced flowering through APETALA
RT 1.";
RL Biochem. Biophys. Res. Commun. 519:585-590(2019).
CC -!- FUNCTION: Transcription activator active in flowering time control. May
CC integrate signals from the photoperiod, vernalization and autonomous
CC floral induction pathways. Can modulate class B and C homeotic genes
CC expression. When associated with AGL24, mediates effect of gibberellins
CC on flowering under short-day conditions, and regulates the expression
CC of LEAFY (LFY), which links floral induction and floral development.
CC {ECO:0000269|PubMed:10995392, ECO:0000269|PubMed:18339670,
CC ECO:0000269|PubMed:18466303, ECO:0000269|PubMed:19656343}.
CC -!- SUBUNIT: Forms a heterodimer with AGL24 through MADS-box domain.
CC Interacts with AGL15, AGL16 and AGL19 (PubMed:15805477,
CC PubMed:18466303). Interacts with OXS3 in the nucleus (PubMed:31540691).
CC {ECO:0000269|PubMed:15805477, ECO:0000269|PubMed:18466303,
CC ECO:0000269|PubMed:31540691}.
CC -!- INTERACTION:
CC O64645; Q38876: AGL8; NbExp=4; IntAct=EBI-592041, EBI-621912;
CC O64645; P35631: AP1; NbExp=5; IntAct=EBI-592041, EBI-592003;
CC O64645; Q39081: CAL; NbExp=4; IntAct=EBI-592041, EBI-592136;
CC O64645; Q9SL42: PIN1; NbExp=3; IntAct=EBI-592041, EBI-2618990;
CC O64645; Q2NJQ2: AYWB_224; Xeno; NbExp=3; IntAct=EBI-592041, EBI-16100490;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251,
CC ECO:0000269|PubMed:18466303, ECO:0000269|PubMed:31540691}. Cytoplasm
CC {ECO:0000269|PubMed:18466303}. Note=Translocation from the cytoplasm to
CC the nucleus in the presence of AGL24.
CC -!- TISSUE SPECIFICITY: Widely expressed. Not found in the apical meristem
CC of short-day grown plants in vegetative stage.
CC -!- DEVELOPMENTAL STAGE: Rapidly up-regulated in apical meristems during
CC the transition to flowering. Transiently expressed in inflorescence
CC meristem. Re-appears in stage 3 flowers, in the central dome that later
CC will develop into stamens and carpels. {ECO:0000269|PubMed:19656343}.
CC -!- INDUCTION: Up-regulated by gibberellins, vernalization and under long-
CC day conditions. Gradual increase during vegetative growth. Induced by
CC AGL24 at the shoot apex at the floral transitional stage. Repressed by
CC SVP during the early stages of flower development. Inhibited by AP1 in
CC emerging floral meristems (PubMed:17428825, PubMed:18339670,
CC PubMed:19656343). Repressed by SHL to prevent flowering
CC (PubMed:25281686). {ECO:0000269|PubMed:17428825,
CC ECO:0000269|PubMed:18339670, ECO:0000269|PubMed:19656343,
CC ECO:0000269|PubMed:25281686}.
CC -!- DISRUPTION PHENOTYPE: Plants are late-flowering.
CC {ECO:0000269|PubMed:11123798}.
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DR EMBL; AC003680; AAC06175.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10583.1; -; Genomic_DNA.
DR EMBL; AY007726; AAG16297.1; -; mRNA.
DR EMBL; AF385731; AAK60321.1; -; mRNA.
DR EMBL; AY093967; AAM16228.1; -; mRNA.
DR PIR; T00879; T00879.
DR RefSeq; NP_182090.1; NM_130128.4.
DR AlphaFoldDB; O64645; -.
DR SMR; O64645; -.
DR BioGRID; 4510; 35.
DR DIP; DIP-33799N; -.
DR ELM; O64645; -.
DR IntAct; O64645; 36.
DR STRING; 3702.AT2G45660.1; -.
DR PaxDb; O64645; -.
DR PRIDE; O64645; -.
DR ProteomicsDB; 232647; -.
DR EnsemblPlants; AT2G45660.1; AT2G45660.1; AT2G45660.
DR GeneID; 819174; -.
DR Gramene; AT2G45660.1; AT2G45660.1; AT2G45660.
DR KEGG; ath:AT2G45660; -.
DR Araport; AT2G45660; -.
DR TAIR; locus:2005522; AT2G45660.
DR eggNOG; KOG0014; Eukaryota.
DR HOGENOM; CLU_053053_0_4_1; -.
DR InParanoid; O64645; -.
DR OMA; SHEIVIW; -.
DR OrthoDB; 1307109at2759; -.
DR PhylomeDB; O64645; -.
DR PRO; PR:O64645; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O64645; baseline and differential.
DR Genevisible; O64645; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IPI:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; TAS:TAIR.
DR GO; GO:0010077; P:maintenance of inflorescence meristem identity; IGI:TAIR.
DR GO; GO:0009911; P:positive regulation of flower development; IMP:TAIR.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009409; P:response to cold; IEP:TAIR.
DR GO; GO:0009739; P:response to gibberellin; IEP:UniProtKB.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002487; TF_Kbox.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF01486; K-box; 1.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS51297; K_BOX; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; Developmental protein; Differentiation; DNA-binding;
KW Flowering; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..214
FT /note="MADS-box protein SOC1"
FT /id="PRO_0000199486"
FT DOMAIN 3..57
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT DOMAIN 87..177
FT /note="K-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
FT REGION 162..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 24
FT /note="R->K: In sso36; suppression of early flowering time
FT mediated by SOC1 over-expression."
FT /evidence="ECO:0000269|PubMed:18466303"
FT MUTAGEN 34
FT /note="E->K: In sso11; partial suppression of early
FT flowering time mediated by SOC1 overexpression."
FT /evidence="ECO:0000269|PubMed:18466303"
FT MUTAGEN 113
FT /note="G->E: In sso4; partial suppression of early
FT flowering time mediated by SOC1 overexpression."
FT /evidence="ECO:0000269|PubMed:18466303"
SQ SEQUENCE 214 AA; 24533 MW; B4D39151DE541F8D CRC64;
MVRGKTQMKR IENATSRQVT FSKRRNGLLK KAFELSVLCD AEVSLIIFSP KGKLYEFASS
NMQDTIDRYL RHTKDRVSTK PVSEENMQHL KYEAANMMKK IEQLEASKRK LLGEGIGTCS
IEELQQIEQQ LEKSVKCIRA RKTQVFKEQI EQLKQKEKAL AAENEKLSEK WGSHESEVWS
NKNQESTGRG DEESSPSSEV ETQLFIGLPC SSRK
