ID   SOCA_CAUVN              Reviewed;         188 AA.
AC   A0A0H3CCP8;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Antitoxin SocA {ECO:0000303|PubMed:24239291};
DE   AltName: Full=Adapter protein SocA {ECO:0000305};
GN   Name=socA {ECO:0000303|PubMed:24239291}; OrderedLocusNames=CCNA_03630;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
RN   [2]
RP   FUNCTION AS AN ANTITOXIN, INTERACTION WITH SOCB AND CLPX, INDUCTION, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=24239291; DOI=10.1016/j.molcel.2013.10.014;
RA   Aakre C.D., Phung T.N., Huang D., Laub M.T.;
RT   "A bacterial toxin inhibits DNA replication elongation through a direct
RT   interaction with the beta sliding clamp.";
RL   Mol. Cell 52:617-628(2013).
CC   -!- FUNCTION: Antitoxin component of an atypical type II toxin-antitoxin
CC       (TA) system. Unlike most type II TA systems, neutralizes the toxic
CC       activity of cognate toxin SocB by acting as an adapter to promote its
CC       degradation by ClpXP; degradation is dependent on the N-terminus of
CC       ClpX. {ECO:0000269|PubMed:24239291}.
CC   -!- SUBUNIT: Interacts with cognate toxin SocB and with ClpX.
CC       {ECO:0000269|PubMed:24239291}.
CC   -!- INDUCTION: Induced by DNA damaging agent mitomycin C, part of the socA-
CC       socB operon. {ECO:0000269|PubMed:24239291}.
CC   -!- DISRUPTION PHENOTYPE: Essential, it cannot be deleted unless the
CC       downstream gene for cognate toxin socB is also deleted. In depletion
CC       experiments the half-life of SocB is 19 minutes in the absence of SocA
CC       and about 2 minutes in its presence. {ECO:0000269|PubMed:24239291}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001340; ACL97095.1; -; Genomic_DNA.
DR   RefSeq; WP_010921344.1; NC_011916.1.
DR   RefSeq; YP_002519003.1; NC_011916.1.
DR   AlphaFoldDB; A0A0H3CCP8; -.
DR   EnsemblBacteria; ACL97095; ACL97095; CCNA_03630.
DR   GeneID; 7329715; -.
DR   KEGG; ccs:CCNA_03630; -.
DR   HOGENOM; CLU_110683_1_0_5; -.
DR   OMA; VYIAHGW; -.
DR   OrthoDB; 1702165at2; -.
DR   Proteomes; UP000001364; Chromosome.
DR   InterPro; IPR025272; SocA_Panacea.
DR   Pfam; PF13274; DUF4065; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..188
FT                   /note="Antitoxin SocA"
FT                   /id="PRO_0000441112"
SQ   SEQUENCE   188 AA;  20424 MW;  37EEC44CDC61DC1F CRC64;
     MPPLTQDPQS VDARAVANLL LDKAAALDIP ISNLALQKLL YFAHGRFLVD KGRPLVNGFF
     EAWKFGPVHP VVYRCFSANG PKYIINRAIK KDILSGLHII VSPPRDQDIH EGIERVLLTM
     GRMSASQLVA VSHASGGPWD VIANGPGTNL GLGLRICDKV IKDRFRFQKV SVSVPPGLGD
     TLEEAPPS