ID   SOCA_MYCTU              Reviewed;          61 AA.
AC   E2FZM4;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Uncharacterized protein SocA {ECO:0000305};
DE   AltName: Full=Small ORF induced by copper A {ECO:0000303|PubMed:21166899};
DE   Flags: Precursor;
GN   Name=socA {ECO:0000303|PubMed:21166899};
GN   OrderedLocusNames=Rv1706c.1 {ECO:0000305};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, AND INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21166899; DOI=10.1111/j.1365-2958.2010.07431.x;
RA   Festa R.A., Jones M.B., Butler-Wu S., Sinsimer D., Gerads R., Bishai W.R.,
RA   Peterson S.N., Darwin K.H.;
RT   "A novel copper-responsive regulon in Mycobacterium tuberculosis.";
RL   Mol. Microbiol. 79:133-148(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=24549843; DOI=10.1128/mbio.00876-13;
RA   Shi X., Festa R.A., Ioerger T.R., Butler-Wu S., Sacchettini J.C.,
RA   Darwin K.H., Samanovic M.I.;
RT   "The copper-responsive RicR regulon contributes to Mycobacterium
RT   tuberculosis virulence.";
RL   MBio 5:E00876-E00876(2014).
CC   -!- INDUCTION: Repressed by RicR. Induced by copper.
CC       {ECO:0000269|PubMed:21166899}.
CC   -!- DISRUPTION PHENOTYPE: Mutant shows wild-type copper resistance.
CC       Mutation does not attenuate growth in mice.
CC       {ECO:0000269|PubMed:24549843}.
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DR   EMBL; HM222605; ADH04621.1; -; Genomic_DNA.
DR   EMBL; AL123456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E2FZM4; -.
DR   PHI-base; PHI:4068; -.
DR   Proteomes; UP000001584; Chromosome.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..61
FT                   /note="Uncharacterized protein SocA"
FT                   /id="PRO_0000433096"
SQ   SEQUENCE   61 AA;  7242 MW;  86EBEE0707F1528A CRC64;
     MHRRARRMPM RPRRSKRVRN RYTMGTFALH GLTHRLPSAS LQTTAARHPD VTQFSMPGHY
     R