SOCS2_PIG
ID SOCS2_PIG Reviewed; 198 AA.
AC Q7YRV6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Suppressor of cytokine signaling 2;
DE Short=SOCS-2;
GN Name=SOCS2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Maccarone P., Drinkwater C.C., Nash A.D.;
RT "Cloning of the swine SOCS2 gene.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Bamei;
RA Chao S., Wen D.B., She Y.G.;
RT "Cloning of the pig SOCS2 gene.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: SOCS family proteins form part of a classical negative
CC feedback system that regulates cytokine signal transduction. SOCS2
CC appears to be a negative regulator in the growth hormone/IGF1 signaling
CC pathway (By similarity). Probable substrate-recognition component of a
CC SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
CC ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins (By similarity).
CC {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with IGF1R (By similarity). Associates with the
CC Elongin BC complex (By similarity). Interacts with AREL1 and PRKCA (By
CC similarity). Interacts with DCUN1D1 (By similarity).
CC {ECO:0000250|UniProtKB:O14508, ECO:0000250|UniProtKB:O35717}.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin ligase
CC complexes. {ECO:0000250}.
CC -!- PTM: Ubiquitinated; mediated by AREL1 and leading to its subsequent
CC proteasomal degradation. Ubiquitination is dependent on phosphorylation
CC at Ser-52, by PKC and is stimulated by LPS.
CC {ECO:0000250|UniProtKB:O35717}.
CC -!- PTM: Phosphorylation at Ser-52 by PKC facilitates its ubiquitination
CC and proteosomal degradation. {ECO:0000250|UniProtKB:O35717}.
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DR EMBL; AY312266; AAP78900.1; -; Genomic_DNA.
DR EMBL; EF121242; ABL61533.1; -; mRNA.
DR RefSeq; NP_001090930.1; NM_001097461.1.
DR RefSeq; XP_005664315.1; XM_005664258.2.
DR RefSeq; XP_005664316.1; XM_005664259.2.
DR RefSeq; XP_005664317.1; XM_005664260.2.
DR RefSeq; XP_013853534.1; XM_013998080.1.
DR RefSeq; XP_013853535.1; XM_013998081.1.
DR RefSeq; XP_013853537.1; XM_013998083.1.
DR RefSeq; XP_013853538.1; XM_013998084.1.
DR AlphaFoldDB; Q7YRV6; -.
DR SMR; Q7YRV6; -.
DR STRING; 9823.ENSSSCP00000000973; -.
DR PaxDb; Q7YRV6; -.
DR PRIDE; Q7YRV6; -.
DR Ensembl; ENSSSCT00000000994; ENSSSCP00000000973; ENSSSCG00000000910.
DR Ensembl; ENSSSCT00005031491; ENSSSCP00005019181; ENSSSCG00005019987.
DR Ensembl; ENSSSCT00015098158; ENSSSCP00015040371; ENSSSCG00015073100.
DR Ensembl; ENSSSCT00025089274; ENSSSCP00025039051; ENSSSCG00025064893.
DR Ensembl; ENSSSCT00030075755; ENSSSCP00030034615; ENSSSCG00030054341.
DR Ensembl; ENSSSCT00035013131; ENSSSCP00035004443; ENSSSCG00035010477.
DR Ensembl; ENSSSCT00040026188; ENSSSCP00040011070; ENSSSCG00040019366.
DR Ensembl; ENSSSCT00045011279; ENSSSCP00045007673; ENSSSCG00045006762.
DR Ensembl; ENSSSCT00050070176; ENSSSCP00050030148; ENSSSCG00050051537.
DR Ensembl; ENSSSCT00055045197; ENSSSCP00055036013; ENSSSCG00055022901.
DR Ensembl; ENSSSCT00060106130; ENSSSCP00060046815; ENSSSCG00060077101.
DR Ensembl; ENSSSCT00065037276; ENSSSCP00065015675; ENSSSCG00065027674.
DR Ensembl; ENSSSCT00065037279; ENSSSCP00065015677; ENSSSCG00065027674.
DR Ensembl; ENSSSCT00065037285; ENSSSCP00065015680; ENSSSCG00065027674.
DR Ensembl; ENSSSCT00065037287; ENSSSCP00065015681; ENSSSCG00065027674.
DR Ensembl; ENSSSCT00070001875; ENSSSCP00070001563; ENSSSCG00070000975.
DR Ensembl; ENSSSCT00070001883; ENSSSCP00070001569; ENSSSCG00070000975.
DR Ensembl; ENSSSCT00070001887; ENSSSCP00070001573; ENSSSCG00070000975.
DR GeneID; 100037966; -.
DR KEGG; ssc:100037966; -.
DR CTD; 8835; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00390000014448; -.
DR HOGENOM; CLU_079452_4_0_1; -.
DR InParanoid; Q7YRV6; -.
DR OMA; AGWYWGN; -.
DR OrthoDB; 1135696at2759; -.
DR TreeFam; TF321368; -.
DR Reactome; R-SSC-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008227; Chromosome 5.
DR Proteomes; UP000314985; Unassembled WGS sequence.
DR Bgee; ENSSSCG00000000910; Expressed in pituitary gland and 43 other tissues.
DR ExpressionAtlas; Q7YRV6; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:Ensembl.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0008269; F:JAK pathway signal transduction adaptor activity; IEA:InterPro.
DR GO; GO:0060396; P:growth hormone receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0007595; P:lactation; IEA:Ensembl.
DR GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
DR GO; GO:0040015; P:negative regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0046426; P:negative regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR CDD; cd10383; SH2_SOCS2; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR028410; SOCS2.
DR InterPro; IPR035862; SOCS2_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155:SF7; PTHR10155:SF7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation; Isopeptide bond; Phosphoprotein; Reference proteome;
KW SH2 domain; Signal transduction inhibitor; Ubl conjugation;
KW Ubl conjugation pathway.
FT CHAIN 1..198
FT /note="Suppressor of cytokine signaling 2"
FT /id="PRO_0000285848"
FT DOMAIN 48..156
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT DOMAIN 151..197
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT REGION 1..75
FT /note="Interaction with AREL1"
FT /evidence="ECO:0000250|UniProtKB:O14508"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14508"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14508"
FT CROSSLNK 173
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:O14508"
SQ SEQUENCE 198 AA; 22254 MW; 3DD77C45F563BCEB CRC64;
MTLRCLEPSG NGAEGTQSQW GTSGSAEEPS PEAARLAKAL RELSHTGWYW GSMTVNEAKE
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD
SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PPLQHLCRLT INKCTGTIWG
LPLPTRLKDY LEEYKFQV
