ID   SODF_METTM              Reviewed;         202 AA.
AC   Q60036; D9PVF8;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Superoxide dismutase [Fe];
DE            EC=1.15.1.1;
GN   Name=sod; Synonyms=sodA; OrderedLocusNames=MTBMA_c06110;
OS   Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS   14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS   thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=79929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=7781971; DOI=10.1111/j.1574-6968.1995.tb07532.x;
RA   Meile L., Fischer K., Leisinger T.;
RT   "Characterization of the superoxide dismutase gene and its upstream region
RT   from Methanobacterium thermoautotrophicum Marburg.";
RL   FEMS Microbiol. Lett. 128:247-253(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=20802048; DOI=10.1128/jb.00844-10;
RA   Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA   Gottschalk G., Thauer R.K.;
RT   "Complete genome sequence of Methanothermobacter marburgensis, a
RT   methanoarchaeon model organism.";
RL   J. Bacteriol. 192:5850-5851(2010).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological systems.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC       {ECO:0000305}.
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DR   EMBL; X74264; CAA52323.1; -; Genomic_DNA.
DR   EMBL; CP001710; ADL58206.1; -; Genomic_DNA.
DR   PIR; S51097; S51097.
DR   RefSeq; WP_013295430.1; NC_014408.1.
DR   AlphaFoldDB; Q60036; -.
DR   SMR; Q60036; -.
DR   STRING; 79929.MTBMA_c06110; -.
DR   EnsemblBacteria; ADL58206; ADL58206; MTBMA_c06110.
DR   GeneID; 9704319; -.
DR   KEGG; mmg:MTBMA_c06110; -.
DR   PATRIC; fig|79929.8.peg.595; -.
DR   HOGENOM; CLU_031625_2_2_2; -.
DR   OMA; KWGSFDK; -.
DR   OrthoDB; 74803at2157; -.
DR   Proteomes; UP000000345; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   Gene3D; 3.55.40.20; -; 1.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Iron; Metal-binding; Oxidoreductase.
FT   CHAIN           1..202
FT                   /note="Superoxide dismutase [Fe]"
FT                   /id="PRO_0000160007"
FT   BINDING         30
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         78
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         164
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         168
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   202 AA;  23829 MW;  5C4FBE27EEE63223 CRC64;
     MEKKFYELPE LPYPYDALEP YISEEQLRIH HEKHHQAYVD GANGVLRKLD DARENGEEVD
     IKAALKELSF HVGGYVLHLF FWGNMGPADE CGGEPDGRLA EYIEKDFGSF QRFKKEFSQA
     AVSAEGSGWA VLTYCQRTDR LFIMQVEKHN VNVIPHFRIL MVLDVWEHAY YIDYRNVRPD
     YVEAFWNIVN WKEVEKRFDD LF