SODF_PLAFA
ID SODF_PLAFA Reviewed; 198 AA.
AC Q9TW89; Q9TVN6; Q9U524; Q9U525; Q9U526; Q9U527; Q9U528; Q9U529; Q9U530;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Superoxide dismutase [Fe];
DE EC=1.15.1.1;
DE AltName: Full=FeSOD;
GN Name=SODB;
OS Plasmodium falciparum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate Gabon 1, Isolate Gabon 10, Isolate Gabon 11,
RC Isolate Gabon 12, Isolate Gabon 13, Isolate Gabon 14, Isolate Gabon 15,
RC Isolate Gabon 16, Isolate Gabon 17, Isolate Gabon 18, Isolate Gabon 19,
RC Isolate Gabon 2, Isolate Gabon 20, Isolate Gabon 21, Isolate Gabon 22,
RC Isolate Gabon 23, Isolate Gabon 24, Isolate Gabon 25, Isolate Gabon 26,
RC Isolate Gabon 3, Isolate Gabon 4, Isolate Gabon 5, Isolate Gabon 6,
RC Isolate Gabon 7, Isolate Gabon 8, and Isolate Gabon 9;
RX PubMed=10585544; DOI=10.1111/j.1574-6968.1999.tb08850.x;
RA Baert C.B., Deloron P., Viscogliosi E., Dauchez M., Camus D., Dive D.;
RT "Analysis of genetic diversity at the iron-containing superoxide dismutase
RT locus in Plasmodium falciparum wild isolates.";
RL FEMS Microbiol. Lett. 181:237-243(1999).
CC -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC produced within the cells and which are toxic to biological systems.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC {ECO:0000305}.
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DR EMBL; AF113142; AAD03746.1; -; Genomic_DNA.
DR EMBL; AF113143; AAD03747.1; -; Genomic_DNA.
DR EMBL; AF113144; AAD03748.1; -; Genomic_DNA.
DR EMBL; AF113145; AAD03749.1; -; Genomic_DNA.
DR EMBL; AF113146; AAD03750.1; -; Genomic_DNA.
DR EMBL; AF113147; AAD03751.1; -; Genomic_DNA.
DR EMBL; AF113148; AAD03752.1; -; Genomic_DNA.
DR EMBL; AF113149; AAD03753.1; -; Genomic_DNA.
DR EMBL; AF113150; AAD03754.1; -; Genomic_DNA.
DR EMBL; AF113151; AAD03755.1; -; Genomic_DNA.
DR EMBL; AF113152; AAD03756.1; -; Genomic_DNA.
DR EMBL; AF113153; AAD03757.1; -; Genomic_DNA.
DR EMBL; AF113154; AAD03758.1; -; Genomic_DNA.
DR EMBL; AF113155; AAD03759.1; -; Genomic_DNA.
DR EMBL; AF113156; AAD03760.1; -; Genomic_DNA.
DR EMBL; AF113157; AAD03761.1; -; Genomic_DNA.
DR EMBL; AF113158; AAD03762.1; -; Genomic_DNA.
DR EMBL; AF113159; AAD03763.1; -; Genomic_DNA.
DR EMBL; AF113160; AAD03764.1; -; Genomic_DNA.
DR EMBL; AF113161; AAD03765.1; -; Genomic_DNA.
DR EMBL; AF113162; AAD03766.1; -; Genomic_DNA.
DR EMBL; AF113163; AAD03767.1; -; Genomic_DNA.
DR EMBL; AF113164; AAD03768.1; -; Genomic_DNA.
DR EMBL; AF113165; AAD03769.1; -; Genomic_DNA.
DR EMBL; AF113166; AAD03770.1; -; Genomic_DNA.
DR EMBL; AF113167; AAD03771.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9TW89; -.
DR SMR; Q9TW89; -.
DR ChEMBL; CHEMBL6077; -.
DR EnsemblProtists; CAD51224; CAD51224; PF3D7_0814900.
DR VEuPathDB; PlasmoDB:PF3D7_0814900; -.
DR VEuPathDB; PlasmoDB:Pf7G8-2_000230200; -.
DR VEuPathDB; PlasmoDB:Pf7G8_080019900; -.
DR VEuPathDB; PlasmoDB:PfCD01_080020400; -.
DR VEuPathDB; PlasmoDB:PfDd2_080020000; -.
DR VEuPathDB; PlasmoDB:PfGA01_080018500; -.
DR VEuPathDB; PlasmoDB:PfGB4_080019600; -.
DR VEuPathDB; PlasmoDB:PfGN01_080020500; -.
DR VEuPathDB; PlasmoDB:PfHB3_080020300; -.
DR VEuPathDB; PlasmoDB:PfIT_080019800; -.
DR VEuPathDB; PlasmoDB:PfKE01_080020400; -.
DR VEuPathDB; PlasmoDB:PfKH01_080019900; -.
DR VEuPathDB; PlasmoDB:PfKH02_080020400; -.
DR VEuPathDB; PlasmoDB:PfML01_080020400; -.
DR VEuPathDB; PlasmoDB:PfNF135_000021500; -.
DR VEuPathDB; PlasmoDB:PfNF166_080018700; -.
DR VEuPathDB; PlasmoDB:PfNF54_080018700; -.
DR VEuPathDB; PlasmoDB:PfSD01_080020200; -.
DR VEuPathDB; PlasmoDB:PfSN01_080019400; -.
DR VEuPathDB; PlasmoDB:PfTG01_080020700; -.
DR OMA; KWGSFDK; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.287.990; -; 1.
DR Gene3D; 3.55.40.20; -; 1.
DR InterPro; IPR001189; Mn/Fe_SOD.
DR InterPro; IPR019833; Mn/Fe_SOD_BS.
DR InterPro; IPR019832; Mn/Fe_SOD_C.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR InterPro; IPR036314; SOD_C_sf.
DR Pfam; PF02777; Sod_Fe_C; 1.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR PIRSF; PIRSF000349; SODismutase; 1.
DR PRINTS; PR01703; MNSODISMTASE.
DR SUPFAM; SSF46609; SSF46609; 1.
DR SUPFAM; SSF54719; SSF54719; 1.
DR PROSITE; PS00088; SOD_MN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Iron; Metal-binding; Oxidoreductase.
FT CHAIN 1..198
FT /note="Superoxide dismutase [Fe]"
FT /id="PRO_0000290111"
FT BINDING 27
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 74
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 158
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 162
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT VARIANT 19
FT /note="I -> V (in strain: isolate Gabon 25)"
FT VARIANT 20
FT /note="S -> G (in strain: isolate Gabon 24)"
FT VARIANT 24
FT /note="L -> I (in strain: isolate Gabon 23)"
FT VARIANT 84
FT /note="D -> G (in strain: isolate Gabon 20)"
FT VARIANT 108
FT /note="K -> E (in strain: isolate Gabon 21)"
FT VARIANT 135
FT /note="V -> A (in strain: isolate Gabon 21)"
FT VARIANT 151
FT /note="G -> S (in strain: isolate Gabon 20)"
FT VARIANT 166
FT /note="I -> T (in strain: isolate Gabon 26)"
FT VARIANT 167
FT /note="D -> N (in strain: isolate Gabon 22)"
SQ SEQUENCE 198 AA; 22734 MW; 0C636B66E6044D3B CRC64;
MVITLPKLKY ALNALSPHIS EETLNFHYNK HHAGYVNKLN TLIKDTPFAE KSLLDIVKES
SGAIFNNAAQ IWNHTFYWDS MGPDCGGEPH GEIKEKIQED FGSFNNFKEQ FSNILCGHFG
SGWGWLALNN NNKLVILQTH DAGNPIKDNT GIPILTCDIW EHAYYIDYRN DRASYVKAWW
NLVNWNFANE NLKKAMQK
