ABH15_MOUSE
ID ABH15_MOUSE Reviewed; 459 AA.
AC Q5F2F2; Q3V371; Q8C9I5; Q8CF57; Q9CU23;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Protein ABHD15 {ECO:0000305};
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 15 {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 15 {ECO:0000312|MGI:MGI:1914727};
DE Flags: Precursor;
GN Name=Abhd15 {ECO:0000312|MGI:MGI:1914727};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Adipose tissue, Liver, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB31349.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC25102.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK018696; BAB31349.1; ALT_FRAME; mRNA.
DR EMBL; AK004929; BAC25102.1; ALT_FRAME; mRNA.
DR EMBL; AK042032; BAC31138.1; -; mRNA.
DR EMBL; AK046590; BAE20655.1; -; mRNA.
DR EMBL; AL591136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS36234.1; -.
DR RefSeq; NP_080461.3; NM_026185.4.
DR AlphaFoldDB; Q5F2F2; -.
DR STRING; 10090.ENSMUSP00000091541; -.
DR ESTHER; mouse-ABH15; abh_upf0017.
DR iPTMnet; Q5F2F2; -.
DR PhosphoSitePlus; Q5F2F2; -.
DR SwissPalm; Q5F2F2; -.
DR EPD; Q5F2F2; -.
DR jPOST; Q5F2F2; -.
DR MaxQB; Q5F2F2; -.
DR PaxDb; Q5F2F2; -.
DR PRIDE; Q5F2F2; -.
DR ProteomicsDB; 296434; -.
DR Antibodypedia; 2595; 51 antibodies from 19 providers.
DR DNASU; 67477; -.
DR Ensembl; ENSMUST00000094004; ENSMUSP00000091541; ENSMUSG00000000686.
DR GeneID; 67477; -.
DR KEGG; mmu:67477; -.
DR UCSC; uc007kha.1; mouse.
DR CTD; 116236; -.
DR MGI; MGI:1914727; Abhd15.
DR VEuPathDB; HostDB:ENSMUSG00000000686; -.
DR eggNOG; KOG1838; Eukaryota.
DR GeneTree; ENSGT00950000182902; -.
DR HOGENOM; CLU_032487_3_0_1; -.
DR InParanoid; Q5F2F2; -.
DR OMA; WKRSYTK; -.
DR OrthoDB; 1162019at2759; -.
DR PhylomeDB; Q5F2F2; -.
DR TreeFam; TF332985; -.
DR BioGRID-ORCS; 67477; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Abhd15; mouse.
DR PRO; PR:Q5F2F2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5F2F2; protein.
DR Bgee; ENSMUSG00000000686; Expressed in brown adipose tissue and 104 other tissues.
DR ExpressionAtlas; Q5F2F2; baseline and differential.
DR Genevisible; Q5F2F2; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR GO; GO:0034338; F:short-chain carboxylesterase activity; IBA:GO_Central.
DR GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR012020; ABHD4.
DR PIRSF; PIRSF005211; Ab_hydro_YheT; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..459
FT /note="Protein ABHD15"
FT /id="PRO_0000345396"
FT ACT_SITE 351
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 382
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6UXT9"
FT CONFLICT 106
FT /note="P -> L (in Ref. 1; BAB31349)"
FT /evidence="ECO:0000305"
FT CONFLICT 147
FT /note="L -> H (in Ref. 1; BAE20655)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="L -> V (in Ref. 1; BAB31349)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="F -> C (in Ref. 1; BAB31349)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 459 AA; 51152 MW; 30D897F050943B82 CRC64;
MPPWAAALAL LLAALALLLL RPWKRAVGAR TSVRDHEEQE VASGGPADQF SDRREALPGG
CSLICKPSAL AQCLLRALRR SAALEPSPRS WLSGPHLQTF CHFILPVGPG PELAREYLQL
ADDGLVALDW VIGPCARGRR VTNPGSLPPV LLVIPNAWGR LTRNVLGLCL LALERGYYPV
IFHRRGHHGC PLVSPRLQPF GDPSDLKEAV TYIRFRHPAA PLFAVSEGSG SALLLSYLGE
CGSSSYVTGA ACISPVLRCR EWFEAGLPWP YERGFLLHQK ISLSRYASAL EDTVDTGKLF
RSGSLREFEE TLFCHTKSCP ISWDTYWDLN DPLRDVDEAA VPVLCICSAD DPVCGPPEHT
LPAELFHSNP YFFLLLSHHG GHCGFLRPEP LPAWSHEVIL ESFRALTEFF RMEERMKGLS
RRRTSFLGGR RRWGGLQKRE VSPSSNLEEI FNWKRSYTR
