SODM1_BACAN
ID SODM1_BACAN Reviewed; 203 AA.
AC Q81LW0; Q6HTB2; Q6KMK4;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Superoxide dismutase [Mn] 1;
DE EC=1.15.1.1;
GN Name=sodA1; Synonyms=sodA-1; OrderedLocusNames=BA_4499, GBAA_4499, BAS4177;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC produced within the cells and which are toxic to biological systems.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC {ECO:0000305}.
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DR EMBL; AE016879; AAP28210.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT33618.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT56477.1; -; Genomic_DNA.
DR RefSeq; NP_846724.1; NC_003997.3.
DR RefSeq; WP_001052031.1; NZ_WXXJ01000027.1.
DR RefSeq; YP_030426.1; NC_005945.1.
DR PDB; 1XUQ; X-ray; 1.80 A; A/B=1-203.
DR PDBsum; 1XUQ; -.
DR AlphaFoldDB; Q81LW0; -.
DR SMR; Q81LW0; -.
DR STRING; 260799.BAS4177; -.
DR DNASU; 1088022; -.
DR EnsemblBacteria; AAP28210; AAP28210; BA_4499.
DR EnsemblBacteria; AAT33618; AAT33618; GBAA_4499.
DR GeneID; 59155151; -.
DR GeneID; 64199622; -.
DR GeneID; 67508913; -.
DR KEGG; ban:BA_4499; -.
DR KEGG; bar:GBAA_4499; -.
DR KEGG; bat:BAS4177; -.
DR PATRIC; fig|198094.11.peg.4467; -.
DR eggNOG; COG0605; Bacteria.
DR HOGENOM; CLU_031625_0_1_9; -.
DR OMA; YEGWKGE; -.
DR EvolutionaryTrace; Q81LW0; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.287.990; -; 1.
DR Gene3D; 3.55.40.20; -; 1.
DR InterPro; IPR001189; Mn/Fe_SOD.
DR InterPro; IPR019833; Mn/Fe_SOD_BS.
DR InterPro; IPR019832; Mn/Fe_SOD_C.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR InterPro; IPR036314; SOD_C_sf.
DR Pfam; PF02777; Sod_Fe_C; 1.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR PIRSF; PIRSF000349; SODismutase; 1.
DR PRINTS; PR01703; MNSODISMTASE.
DR SUPFAM; SSF46609; SSF46609; 1.
DR SUPFAM; SSF54719; SSF54719; 1.
DR PROSITE; PS00088; SOD_MN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Manganese; Metal-binding; Oxidoreductase; Reference proteome.
FT CHAIN 1..203
FT /note="Superoxide dismutase [Mn] 1"
FT /id="PRO_0000160012"
FT BINDING 28
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 83
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 165
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000250"
FT TURN 13..19
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 22..30
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 32..44
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 48..51
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 55..60
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 62..64
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 67..88
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 100..110
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 113..126
FT /evidence="ECO:0007829|PDB:1XUQ"
FT STRAND 129..138
FT /evidence="ECO:0007829|PDB:1XUQ"
FT STRAND 141..148
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 153..156
FT /evidence="ECO:0007829|PDB:1XUQ"
FT STRAND 159..165
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 168..170
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 172..175
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 179..186
FT /evidence="ECO:0007829|PDB:1XUQ"
FT TURN 187..189
FT /evidence="ECO:0007829|PDB:1XUQ"
FT HELIX 192..201
FT /evidence="ECO:0007829|PDB:1XUQ"
SQ SEQUENCE 203 AA; 22664 MW; 61B0B7D44A090D97 CRC64;
MAKHELPNLP YAYDALEPHF DKETMNIHHT KHHNTYITNL NAALEGHAEL ADKSVEELVA
NLNEVPEAIR TAVRNNGGGH ANHTFFWTIL SPNGGGQPVG ELATAIEAKF GSFDAFKEEF
AKAGATRFGS GWAWLVVNNG ELEVTSTPNQ DSPLTEGKTP VIGLDVWEHA YYLNYQNRRP
DYIGAFWNVV DWNAAEKRYQ EAK
