ID   SODM2_HALME             Reviewed;         146 AA.
AC   O08460;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Superoxide dismutase [Mn] 2;
DE            EC=1.15.1.1;
DE   Flags: Fragment;
GN   Name=sod2;
OS   Haloferax mediterranei (Halobacterium mediterranei).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=2252;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9106366; DOI=10.1128/mmbr.61.1.90-104.1997;
RA   Dennis P.P., Shimmin L.C.;
RT   "Evolutionary divergence and salinity-mediated selection in halophilic
RT   archaea.";
RL   Microbiol. Mol. Biol. Rev. 61:90-104(1997).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological systems.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC       {ECO:0000305}.
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DR   EMBL; U78907; AAB60931.1; -; Genomic_DNA.
DR   AlphaFoldDB; O08460; -.
DR   SMR; O08460; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   Gene3D; 3.55.40.20; -; 1.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Manganese; Metal-binding; Oxidoreductase.
FT   CHAIN           <1..>146
FT                   /note="Superoxide dismutase [Mn] 2"
FT                   /id="PRO_0000160120"
FT   BINDING         42
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         126
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         130
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         146
SQ   SEQUENCE   146 AA;  16147 MW;  6393E3A00D47D41D CRC64;
     GYVNGLNAAE ETLRENRSSG DMDGSAAAMR SVSHNGCGHY LHHLFWRCMT PNGGGGEPTG
     DLRDRIESDF GSYEGWEAEF REAASWPAGG WALLVYDPVT KQLRNLAVQK HNDGALWSAH
     PILALDVWEH SYYFQYGPDR GGFVDA