ID   SODM2_HALSA             Reviewed;         200 AA.
AC   P09224; Q03299; Q9HQ47;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 3.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Superoxide dismutase [Mn] 2;
DE            EC=1.15.1.1;
GN   Name=sod2; Synonyms=slg, sod1; OrderedLocusNames=VNG_1332G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3240866; DOI=10.1016/0378-1119(88)90113-8;
RA   Salin M.L., Duke M.V., Oesterhelt D., Ma D.-P.;
RT   "Cloning and determination of the nucleotide sequence of the Mn-containing
RT   superoxide dismutase gene from Halobacterium halobium.";
RL   Gene 70:153-159(1988).
RN   [2]
RP   ERRATUM OF PUBMED:3240866.
RA   Salin M.L., Duke M.V., Oesterhelt D., Ma D.-P.;
RL   Gene 87:153-153(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2681164; DOI=10.1128/jb.171.11.6323-6329.1989;
RA   Takao M., Kobayashi T., Oikawa A., Yasui A.;
RT   "Tandem arrangement of photolyase and superoxide dismutase genes in
RT   Halobacterium halobium.";
RL   J. Bacteriol. 171:6323-6329(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1694523; DOI=10.1128/jb.172.7.3725-3729.1990;
RA   May B.P., Dennis P.P.;
RT   "Unusual evolution of a superoxide dismutase-like gene from the extremely
RT   halophilic archaebacterium Halobacterium cutirubrum.";
RL   J. Bacteriol. 172:3725-3729(1990).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GRB;
RX   PubMed=8449865; DOI=10.1128/jb.175.6.1561-1571.1993;
RA   Joshi P.B., Dennis P.P.;
RT   "Characterization of paralogous and orthologous members of the superoxide
RT   dismutase gene family from genera of the halophilic archaebacteria.";
RL   J. Bacteriol. 175:1561-1571(1993).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological systems.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase family.
CC       {ECO:0000305}.
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DR   EMBL; M22408; AAA72704.1; -; Genomic_DNA.
DR   EMBL; M24544; AAA72750.1; -; Genomic_DNA.
DR   EMBL; M26502; AAA72770.1; -; Genomic_DNA.
DR   EMBL; M97483; AAA73372.1; -; Genomic_DNA.
DR   EMBL; AE004437; AAG19670.1; -; Genomic_DNA.
DR   PIR; B84288; B84288.
DR   PIR; C32580; DSHSNH.
DR   PIR; T50047; T50047.
DR   RefSeq; WP_010902966.1; NC_002607.1.
DR   AlphaFoldDB; P09224; -.
DR   SMR; P09224; -.
DR   STRING; 64091.VNG_1332G; -.
DR   PaxDb; P09224; -.
DR   EnsemblBacteria; AAG19670; AAG19670; VNG_1332G.
DR   GeneID; 5952922; -.
DR   GeneID; 62886811; -.
DR   KEGG; hal:VNG_1332G; -.
DR   PATRIC; fig|64091.14.peg.1018; -.
DR   HOGENOM; CLU_031625_2_1_2; -.
DR   InParanoid; P09224; -.
DR   OMA; YEGWKGE; -.
DR   OrthoDB; 74803at2157; -.
DR   PhylomeDB; P09224; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   Gene3D; 3.55.40.20; -; 1.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Manganese; Metal-binding; Oxidoreductase; Reference proteome.
FT   CHAIN           1..200
FT                   /note="Superoxide dismutase [Mn] 2"
FT                   /id="PRO_0000160115"
FT   BINDING         28
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         76
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         158
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   BINDING         162
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        24
FT                   /note="V -> A (in Ref. 5; AAA73372)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        46
FT                   /note="T -> N (in Ref. 5; AAA73372)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        49
FT                   /note="E -> G (in Ref. 5; AAA73372)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        174
FT                   /note="S -> T (in Ref. 1; AAA72704)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   200 AA;  22208 MW;  736E7B223BDAE260 CRC64;
     MSQHELPSLP YDYDALEPHI SEQVVTWHHD THHQSYVDGL NSAEETLAEN RETGDHASTA
     GALGDVTHNG CGHYLHTMFW EHMSPDGGGE PSGALADRIA ADFGSYENWR AEFEVAAGAA
     SGWALLVYDP VAKQLRNVAV DNHDEGALWG SHPILALDVW EHSYYYDYGP DRGSFVDAFF
     EVIDWDPIAA NYDDVVSLFE